DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4e3 and Cyp4s3

DIOPT Version :9

Sequence 1:	NP_523527.1	Gene:	Cyp4e3 / 34291	FlyBaseID:	FBgn0015035	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster

Alignment Length:	536	Identity:	186/536 - (34%)
Similarity:	284/536 - (52%)	Gaps:	70/536 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWLAVLALL--VLPLITLVYFERKASQRRQLLKEFNGPTPVPILGNANRIGKNPAEILSTFFDWW 63
            :|.|.|..|  :|..:.|          ::..|...|||...::.|..:     .|||    :|.
  Fly    11 LWAAFLRYLPKILNFLRL----------QRFAKTLPGPTIGELIANVKK-----GEIL----NWL 56

  Fly    64 YDYGKDN---FLFWIGYSSHIVMTNPKQLEYILNSQQLIQKSTIYDLLHPWLGHGLLTSFGSKWH 125
            .:..:.:   |..|.|....::.|:|:.::.:|.:.||:.||..|:||.||||.||||:.|..||
  Fly    57 KELREKHGPVFRIWFGKDLMVMFTDPEDIKQLLGNNQLLTKSRNYELLEPWLGKGLLTNGGESWH 121

  Fly   126 KHRKMITPSFHFNILQDFHEVMNENSAKFMTQLKKASAGDTIIDFQEHANYLTLDVICDTAMGVP 190
            :.||::||.|||.||.:|.|.|.||....:.:|:..:.|:: .|...:.....||.||:||||:.
  Fly   122 RRRKLLTPGFHFRILSEFKEPMEENCRILVRRLRTKANGES-FDIYPYITLFALDAICETAMGIK 185

  Fly   191 INAMEQRDSSIVQAFRDMCYNINMRAFHPFKRSNRVFSLTPEFSAYQKTLKTLQDFTYDIIE-KR 254
            .:|..|.||..|||.:.:|..::.::|..::|.|..|..|......:..||.|.|.|..:|. :|
  Fly   186 KHAQLQSDSEYVQAVQSICRVMHKQSFSFWQRLNVFFKHTKPGKEREAALKVLHDETNRVIRLRR 250

  Fly   255 VYALQNGGS---KEDHDPSLPRKKMAFLDTLLSSTID-GRPLTRQEIYEEVSTFMFEGHDTTTSG 315
            ...:|....   :.:.|....::::||||.||.:.:: |..|:..:|.|||.||||||||||:|.
  Fly   251 EQLIQERNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGGAELSDTDIREEVDTFMFEGHDTTSSA 315

  Fly   316 VSFSVYLLSRHPDVQRKLYREQCEVMGHDMNRSVSFQEIAKMKYLDLFIKEAQRVYPSVPFIGRY 380
            ::|::.|||::||||::.:.|..|:.|         :|...|.||:..|||..|:||||||..|.
  Fly   316 IAFALSLLSKNPDVQQRAFEEASELEG---------REKESMPYLEAVIKETLRIYPSVPFFSRK 371

  Fly   381 CDKDYDINGSIVPKGTTLNLALILLGYNDRIFKDPHHFRPERF--EEEKPAPFEYLPFSAGPRNC 443
            ..:|.::....||||.:::..:.:|..:.:.|.||..|.|:||  .|::..||.:..||||||||
  Fly   372 VLEDLEVGKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRFLVNEKQMHPFAFAAFSAGPRNC 436

  Fly   444 IGQKFALLELKTVISKVVRSFEVLPAVDELVSTDGRLNTYLGLAPDEKLKREAGRHKYDPILSAV 508
            ||||||:|||||.::.::||:..||..|                           |:..|:  |.
  Fly   437 IGQKFAMLELKTSLAMLLRSYRFLPDKD---------------------------HQPKPL--AE 472

  Fly   509 LTLKSDNGLHLRLRER 524
            |..||.||:.||:..|
  Fly   473 LVTKSGNGIRLRILPR 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	p450	35..468	CDD:278495	165/442 (37%)
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	169/479 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460456
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10482at33392
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	11	10.800