DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e3 and Cyp4f39

DIOPT Version :9

Sequence 1:	NP_523527.1	Gene:	Cyp4e3 / 34291	FlyBaseID:	FBgn0015035	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_796281.1	Gene:	Cyp4f39 / 320997	MGIID:	2445210	Length:	532	Species:	Mus musculus

Alignment Length:	547	Identity:	152/547 - (27%)
Similarity:	276/547 - (50%)	Gaps:	72/547 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 VLALLVLPLITLVYFERKASQRRQLLKEFN------GPTPVP-----ILGN-----ANRIG-KNP 52
            |..:..|.|:.|.:|.|...:..:|..:|.      ...|.|     :||:     .|..| :|.
Mouse    21 VYVVSALLLLVLFFFFRLLVRAFKLFSDFRITCRKLSCFPEPPGRHWLLGHMSMYLPNEKGLQNE 85

  Fly    53 AEILSTFFDWWYDYGKDNFLFWIG-YSSHIVMTNPKQLEYILNSQQLI--QKSTIYDLLHPWLGH 114
            .::|.|.        ....|.|:| :...:|:.:|..::.:|.:...|  :....|..|.||||.
Mouse    86 KKVLDTM--------HHIILAWVGPFLPLLVLVHPDYIKPVLGASAAIAPKDEFFYSFLKPWLGD 142

  Fly   115 GLLTSFGSKWHKHRKMITPSFHFNILQDFHEVMNENS----AKFMTQLKKASAGDTIIDFQEHAN 175
            |||.|.|:||.:||:::||:|||:||:.:.::.|:.:    ||:...|.:.|.  |..|..||.:
Mouse   143 GLLISKGNKWSRHRRLLTPAFHFDILKPYMKIFNQCTNIMHAKWRRHLAEGSV--TSFDMFEHIS 205

  Fly   176 YLTLDVICDTAMGVPINAMEQRDSSIVQAFRDMCYNINMRAFHPFKRSNRVFSLTPEFSAYQKTL 240
            .:|||.:.........:..| |.|..:.:..::...:..|.:......:.::.||.:...:::..
Mouse   206 LMTLDSLQKCVFSYNSDCQE-RMSDYISSIIELSALVVRRQYRLHHYLDFMYYLTADGRRFRQAC 269

  Fly   241 KTLQDFTYDIIEKRVYALQNGGSKEDHDPSLPRKKMAFLDT-LLSSTIDGRPLTRQEIYEEVSTF 304
            .|:.:||.::|::|..||:..|: |....:...|.:.|:|. ||:...:|:.|:.::|..|..||
Mouse   270 DTVHNFTTEVIQERRQALRQQGA-EAWLKAKQGKTLDFIDVLLLAKDEEGKELSDEDIRAEADTF 333

  Fly   305 MFEGHDTTTSGVSFSVYLLSRHPDVQRKLYREQCEVM-GHDMNRSVSFQEIAKMKYLDLFIKEAQ 368
            ||||||||:||:|::::.|:::|:.|.|...|..||| |.:: ..:.:.::.::.:..:.|||:.
Mouse   334 MFEGHDTTSSGLSWALFNLAKYPEYQEKCREEIQEVMKGREL-EELDWDDLTQLPFTTMCIKESL 397

  Fly   369 RVYPSVPFIGRYCDKDYDI-NGSIVPKGTTLNLALILLGYNDRIFKDPHHFRPERFEEEKP---A 429
            |.:|.|..|.|.|.:|..: :|.::|||....:::....:|..::.|...:.|.||:.:.|   :
Mouse   398 RQFPPVTLISRRCTEDIKLPDGRVIPKGIICLVSIYGTHHNPIVWPDSKVYNPYRFDPDTPQQRS 462

  Fly   430 PFEYLPFSAGPRNCIGQKFALLELKTVISKVVRSFEVLPAVDELVSTDGRLNTYLGLAPDEKLKR 494
            |..::||||||||||||.||:.|::.|::..:..|.:  :||.                ..|::|
Mouse   463 PLAFVPFSAGPRNCIGQSFAMAEMRVVVALTLLRFRL--SVDR----------------THKVRR 509

  Fly   495 EAGRHKYDPILSAVLTLKSDNGLHLRL 521
            :           ..|.|:::|||.|.:
Mouse   510 K-----------PELILRTENGLWLNV 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	p450	35..468	CDD:278495	134/456 (29%)
Cyp4f39	NP_796281.1	p450	60..515	CDD:365848	139/496 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844905
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.650