DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e3 and Cyp4ae1

DIOPT Version :9

Sequence 1:	NP_523527.1	Gene:	Cyp4e3 / 34291	FlyBaseID:	FBgn0015035	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_525044.1	Gene:	Cyp4ae1 / 31193	FlyBaseID:	FBgn0015036	Length:	496	Species:	Drosophila melanogaster

Alignment Length:	533	Identity:	196/533 - (36%)
Similarity:	294/533 - (55%)	Gaps:	55/533 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLVLPLITLVYFERKASQRRQLLKEFNGP--------TPVPILGNANRIGK-NPAEILSTFFDWW 63
            :||:.|:.|:.....||..|..|||...|        :.||:||.|.::.. .|..:...|.::.
  Fly     1 MLVVLLVALLVTRLVASLFRLALKELRHPLQGVVPSVSRVPLLGAAWQMRSFQPDNLHDKFAEYV 65

  Fly    64 YDYGKDNFLFWIGYSSHIVM--TNPKQLEYILNSQQLIQKSTIYDLLHPWLGHGLLTSFGSKWHK 126
            ..:|:.   |......|:||  ..|:.::.:|..|..::|.|:|..|..|||.|||.|.|.:||.
  Fly    66 KRFGRS---FMGTVLGHVVMVTAEPRHIDALLQGQHQLKKGTMYFALRGWLGDGLLLSRGKEWHT 127

  Fly   127 HRKMITPSFHFNILQDFHEVMNENSAKFMTQLKKASAGDTIIDFQEHANYLTLDVICDTAMGVPI 191
            .||:|||:|||:||:.|.||.:..|:..:.:|:..|.|:.:::.........||:|.:|||||.:
  Fly   128 MRKIITPTFHFSILEQFVEVFDRQSSILVERLRTLSYGNEVVNIYPLVGLAALDIITETAMGVNV 192

  Fly   192 NAMEQRDSSIVQAFRDMCYNINMRAFHPFKRSNRVFSLT-PE-FSAYQKTLKTLQDFTYDIIEKR 254
            :| :..||.:|.|.:|:...:..|...|......:|.|. |. |...|..:..|.:||..|||:|
  Fly   193 DA-QGADSEVVHAVKDLTNILATRFMRPHLLFPHLFRLCWPSGFRKQQAGVICLHEFTNGIIEQR 256

  Fly   255 VYALQNGGSKEDHDPSLPRKKMAFLDTLLSSTIDGRPLTRQEIYEEVSTFMFEGHDTTTSGVSFS 319
            ...|....:::.     |.|..|.|||||.:|:||:|||.::|.:||:||:|||||||||.|||.
  Fly   257 RRLLAREANQDK-----PTKPHALLDTLLRATVDGQPLTDKQIRDEVNTFIFEGHDTTTSAVSFC 316

  Fly   320 VYLLSRHPDVQRKLYREQCEVMGHDMNRSVSFQEIAKMKYLDLFIKEAQRVYPSVPFIGRYCDKD 384
            :||||||..||:||:.|.....|.|:.|.|...:.|.:.||...:||:.|:||.:|.:.|..:||
  Fly   317 LYLLSRHEAVQQKLFEELRMHYGQDLFRGVILSDFATLPYLSCVVKESLRLYPPIPAVARCLEKD 381

  Fly   385 YDINGSIVPKGTTLNLALILLGYNDRIFKDPHHFRPER-FEEEKP--APFEYLPFSAGPRNCIGQ 446
            ..|:...:|.||.:.:.|..|..::.||.||..|:||| ..||.|  :|:.|:||||||||||||
  Fly   382 LVIDEGYIPVGTNVVVLLWQLLRDEAIFTDPLVFQPERHLGEEAPRLSPYSYIPFSAGPRNCIGQ 446

  Fly   447 KFALLELKTVISKVVRSFEVLPAVDELVSTDGRLNTYLGLAPDEKLKREAGRHKYDPILSAVLTL 511
            ||||||:||:::||:|.:::||               :|...:..:|               :.|
  Fly   447 KFALLEMKTMVTKVIRHYQLLP---------------MGADVEPSIK---------------IVL 481

  Fly   512 KSDNGLHLRLRER 524
            :|.:|:::.||.|
  Fly   482 RSKSGVNVGLRPR 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	p450	35..468	CDD:278495	176/448 (39%)
Cyp4ae1	NP_525044.1	p450	35..486	CDD:278495	181/489 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449019
Domainoid	1	1.000	160	1.000	Domainoid score	I1269
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10482at33392
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	10	9.900