Protein Alignment Cyp4e3 and Cyp4f18

DIOPT Version :10

• Sequence 1: NP_523527.1
• Gene: Cyp4e3 / 34291
• FlyBaseID: FBgn0015035
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_001028858.2
• Gene: Cyp4f18 / 290623
• RGDID: 1305261
• Length: 524
• Species: Rattus norvegicus
• Alignment Length: 545
• Identity: 155/545 - (28%)
• Similarity: 262/545 - (48%)
• Gaps: 72/545 - (13%)

  Fly     2 WLAVLAL-------LVLPLITLVYFERKASQRRQLLKEFNGPTPVPILGNANRIGKNPAEIL--- 56
            ||.:|.:       .:||.:..|:     ...|:|.:....||...:.|:...|..:...:|
  Rat    19 WLLLLLVGASCLLAYILPQVYAVF-----ENSRRLRRFPQPPTRNWLFGHLGLIQSSEEGLLYIQ 78

  Fly    57 ---STFFDWWYDYGKDNFLFWIG-YSSHIVMTNPKQLE-YILNSQQLIQKSTI-YDLLHPWLGHG 115
               .||        :|...:|:| :...|.:.:|..:: .||....:..|..: |..|.||||.|
  Rat    79 SLSRTF--------RDVCCWWVGPWHPVIRIFHPAFIKPVILAPASVAPKDRVFYRFLKPWLGDG 135

  Fly   116 LLTSFGSKWHKHRKMITPSFHFNILQDFHEVMNENS----AKFMTQLKKASAGDTIIDFQEHANY 176
            ||.|.|.||.:||.|:||:||||||:.:.::.|:::    ||:.   :.||.|...:|..||.:.
  Rat   136 LLLSTGDKWSRHRHMLTPAFHFNILKPYVKIFNDSTNIMHAKWQ---RLASQGSARLDMFEHISL 197

  Fly   177 LTLDVICDTAMGVPINAMEQRDSSIVQAFRDMCYNINMRAFHPFKRSNRVFSLTPEFSAYQKTLK 241
            :|||.:.........|..| :.|..:.|..::...:..|........:..:.||.:...::|..:
  Rat   198 MTLDSLQKCVFSFDSNCQE-KPSEYITAILELSALVARRHQSLLLYVDLFYHLTRDGMRFRKACR 261

  Fly   242 TLQDFTYDIIEKRVYALQNGGSKEDHDPSLPRKKMAFLDTLLSSTID-GRPLTRQEIYEEVSTFM 305
            .:.|||..:|.:|...|.:.|..:........|.:.|:|.||.|..: |..|:.::|..|..|||
  Rat   262 LVHDFTDAVIRERRRTLPDQGGDDALKAKAKAKTLDFIDVLLLSKDEHGEALSDEDIRAEADTFM 326

  Fly   306 FEGHDTTTSGVSFSVYLLSRHPDVQRKLYREQCEVMGHDMNRSVSFQEIAKMKYLDLFIKEAQRV 370
            |.|||||.||:|:.:|.|::||:.|.:..:|..|::.......:.:.::|::.:|.:.|||:.|:
  Rat   327 FGGHDTTASGLSWILYNLAKHPEYQERCRQEVRELLRDREPEEIEWDDLAQLPFLTMCIKESLRL 391

  Fly   371 YPSVPFIGRYCDKDYDI-NGSIVPKGTTLNLALILLGYNDRIFKDPHHFRPERFEE---EKPAPF 431
            :|....|.|.|.:|..: :|.::|||....:::....:|..::.||..:.|.||:.   |..:|.
  Rat   392 HPPATAISRCCTQDIMLPDGRVIPKGVICRISIFGTHHNPAVWPDPEVYNPFRFDADNGEGRSPL 456

  Fly   432 EYLPFSAGPRNCIGQKFALLELKTVISKVVRSFEVLPAVDELVSTDGRLNTYLGLAPDEKLKREA 496
            .::||||||||||||.||:.|:|..::..:..|.||                    ||:|
  Rat   457 AFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRVL--------------------PDDK----- 496

  Fly   497 GRHKYDPILSAVLTLKSDNGLHLRL 521
                 :|.....|.|:::.||.||:
  Rat   497 -----EPRRKPELILRAEGGLWLRV 516

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	CYP4	68..519	CDD:410721	138/462 (30%)
Cyp4f18	NP_001028858.2	CYP4F	74..515	CDD:410772	141/482 (29%)