Protein Alignment Cyp4e3 and CYP4V2

DIOPT Version :10

• Sequence 1: NP_523527.1
• Gene: Cyp4e3 / 34291
• FlyBaseID: FBgn0015035
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_997235.3
• Gene: CYP4V2 / 285440
• HGNCID: 23198
• Length: 525
• Species: Homo sapiens
• Alignment Length: 555
• Identity: 193/555 - (34%)
• Similarity: 289/555 - (52%)
• Gaps: 76/555 - (13%)

  Fly     1 MWLAVLAL------LVLPLITLV-YFERKASQRRQLLKEFNGPT---PVPILGNANRIGKNPAEI 55
            :|.|..||      |||.|:..| .:.||..|.|.:      ||   ..|::|:|..:..:..|.
Human    15 LWGAASALSLAGASLVLSLLQRVASYARKWQQMRPI------PTVARAYPLVGHALLMKPDGREF 73

  Fly    56 LSTFFDWWYDYGKDNFL-FWIGYSSHIVMTNPKQLEYILNSQQLIQKSTIYDLLHPWLGHGLLTS 119
            .....::..:|.....| .|:|....:.:.|.:.:|.||.|.:.|.||::|..|.||||.|||||
Human    74 FQQIIEYTEEYRHMPLLKLWVGPVPMVALYNAENVEVILTSSKQIDKSSMYKFLEPWLGLGLLTS 138

  Fly   120 FGSKWHKHRKMITPSFHFNILQDFHEVMNENSAKFMTQLKKASAGDTIIDFQEHAN--------Y 176
            .|:||...|||:||:|||.||:||.::|||.:...:.:|:|            |.|        |
Human   139 TGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEK------------HINQEAFNCFFY 191

  Fly   177 LT---LDVICDTAMGVPINAMEQRDSSIVQAFRDMCYNINMRAFHPFKRSNRVFSLTPEFSAYQK 238
            :|   ||:||:||||..|.|....||..|:|...|...|..|...|:...:..:.:..|...::|
Human   192 ITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEGWEHKK 256

  Fly   239 TLKTLQDFTYDIIEKRVYALQ-NGGSKEDHDPSLP--RKKMAFLDTLLSSTID-GRPLTRQEIYE 299
            :|:.|..||..:|.:|...:. |...:.|...|.|  .|:.||||.|||.|.| |..|:.::|.|
Human   257 SLQILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLLSVTDDEGNRLSHEDIRE 321

  Fly   300 EVSTFMFEGHDTTTSGVSFSVYLLSRHPDVQRKLYREQCEVMGHDMNRSVSFQEIAKMKYLDLFI 364
            ||.||||||||||.:.:::|:|||..:|:||:|:..|..:|.|.. :|..:.:::.|::||:..|
Human   322 EVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKS-DRPATVEDLKKLRYLECVI 385

  Fly   365 KEAQRVYPSVPFIGRYCDKDYDINGSIVPKGTTLNLALILLGYNDRIFKDPHHFRPERFEEEKPA 429
            ||..|::||||...|...:|.::.|..|.|||...:....|..:.|.|.:|..|:||||..|...
Human   386 KETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENAQ 450

  Fly   430 ---PFEYLPFSAGPRNCIGQKFALLELKTVISKVVRSFEVLPAVDELVSTDGRLNTYLGLAPDEK 491
               |:.|:|||||||||||||||::|.||::|.::|.|.:
Human   451 GRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWI------------------------- 490

  Fly   492 LKREAGRHKYDPILSAVLTLKSDNGLHLRLRERRS 526
               |:.:.:.:..|...|.|:..||:.::|:.|.:
Human   491 ---ESNQKREELGLEGQLILRPSNGIWIKLKRRNA 522

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	CYP4	68..519	CDD:410721	171/469 (36%)
CYP4V2	NP_997235.3	CYP4V	76..515	CDD:410773	172/479 (36%)