Protein Alignment Cyp4e3 and CYP4A22

DIOPT Version :9

• Sequence 1: NP_523527.1
• Gene: Cyp4e3 / 34291
• FlyBaseID: FBgn0015035
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_001010969.2
• Gene: CYP4A22 / 284541
• HGNCID: 20575
• Length: 519
• Species: Homo sapiens
• Alignment Length: 551
• Identity: 163/551 - (29%)
• Similarity: 261/551 - (47%)
• Gaps: 93/551 - (16%)

  Fly     3 LAVLALLVLPLITLVYFERKASQ----RRQLLK---EFNGPTPVPILGNANRIGKNP-----AEI 55
            |.|.:||:|.|:.:     ||:|    |:.|||   :|..|....:.|:......:.     .|.
Human    19 LQVTSLLILLLLLI-----KAAQLYLHRQWLLKALQQFPCPPSHWLFGHIQEFQHDQELQRIQER 78

  Fly    56 LSTFFDWWYDYGKDNFLFWI-GYSSHIVMTNPKQLEYILNSQQLIQKSTIYDLLHPWLGHGLLTS 119
            :.||        .....:|| |....:.:.:|..::.||.........: |..|.|.:|:|||..
Human    79 VKTF--------PSACPYWIWGGKVRVQLYDPDYMKVILGRSDPKSHGS-YKFLAPRIGYGLLLL 134

  Fly   120 FGSKWHKHRKMITPSFHFNILQDFHEVMNENSAKFMTQLKKASAGDTIIDFQEHANYLTLDVICD 184
            .|..|.:||:|:||:||.:||:.:..:|.::....:.:.::....|:.::..:|.:.:|||.|..
Human   135 NGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMK 199

  Fly   185 TAMGVPINAMEQRDS-SIVQAFRDM-----CYNINMRAFHPFKRSNRVFSLTPEFSAYQKTLKTL 243
            :|.....:....|:| |.:||..|:     |...|  |||   .::.::|||.......:..:..
Human   200 SAFSHQGSIQVDRNSQSYIQAISDLNSLVFCCMRN--AFH---ENDTIYSLTSAGRWTHRACQLA 259

  Fly   244 QDFTYDIIEKRVYALQNGGSKEDHDPSLPRKK-MAFLDTLLSSTID-GRPLTRQEIYEEVSTFMF 306
            ...|..:|:.|...||..|..|    .:.||: :.|||.||.:.:: |..|:.:::..||.||||
Human   260 HQHTDQVIQLRKAQLQKEGELE----KIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMF 320

  Fly   307 EGHDTTTSGVSFSVYLLSRHPDVQRKLYREQCEVMGHDM---NRSVSFQEIAKMKYLDLFIKEAQ 368
            ||||||.||:|:.:|.|:.||.     ::|:|....|.:   ..|:::..:.:|.|..:.||||.
Human   321 EGHDTTASGISWILYALATHPK-----HQERCREEIHGLLGDGASITWNHLDQMPYTTMCIKEAL 380

  Fly   369 RVYPSVPFIGRYCDKDYDI-NGSIVPKGTTLNLALILLGYNDRIFKDPHHFRPERFEEEKPAP-- 430
            |:||.||.|||........ :|..:|||..:.|::..|.:|.:::.:...|.|.||     ||
Human   381 RLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSRF-----APGS 440

  Fly   431 ----FEYLPFSAGPRNCIGQKFALLELKTVISKVVRSFEVLPAVDELVSTDGRLNTYLGLAPDEK 491
                ..:||||.|.|||||::||:.:||...:..:..||:||....:
Human   441 AQHSHAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFELLPDPTRI------------------ 487

  Fly   492 LKREAGRHKYDPILSAVLTLKSDNGLHLRLR 522
                       ||..|.|.|||.||:|||||
Human   488 -----------PIPMARLVLKSKNGIHLRLR 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	p450	35..468	CDD:278495	133/456 (29%)
CYP4A22	NP_001010969.2	p450	52..505	CDD:278495	145/509 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154741
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D214327at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.650