Protein Alignment Cyp4e3 and Cyp4a12a

DIOPT Version :10

• Sequence 1: NP_523527.1
• Gene: Cyp4e3 / 34291
• FlyBaseID: FBgn0015035
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_803125.2
• Gene: Cyp4a12a / 277753
• MGIID: 88612
• Length: 508
• Species: Mus musculus
• Alignment Length: 533
• Identity: 146/533 - (27%)
• Similarity: 259/533 - (48%)
• Gaps: 69/533 - (12%)

  Fly    10 VLPLITLVYFERKASQRRQLL----KEFNGPTPVPILGNANRIGKNPAEILSTFFDW------WY 64
            ||.|:.|::...:....||.|    ::|..|....:.|:.....::..:||:...::      |
Mouse    24 VLSLLLLLFKTAQLYLHRQWLLSSTQQFPSPPSHWLFGHKILKDQDLQDILTRIKNFPSACPQW- 87

  Fly    65 DYGKDNFLFWIGYSSHIVMTNPKQLEYILNSQQLIQKSTIYDLLHPWLGHGLLTSFGSKWHKHRK 129
                    .| |....|.:.:|..::.||.... .:.:..|..|.||:|.|||...|..|.:||:
Mouse    88 --------LW-GSKVRIQVYDPDYMKLILGRSD-PKANGSYRFLAPWIGRGLLMLDGQTWFQHRR 142

  Fly   130 MITPSFHFNILQDFHEVMNENSAKFMTQLKKASAGDTIIDFQEHANYLTLDVICDTAMGVPINA- 193
            |:||:||::||:.:.|:|.::....:.:.::....|:.::...|...:|||.|...|.....:.
Mouse   143 MLTPAFHYDILKPYTEIMADSVRVMLDKWEQIVGQDSTLEIFRHITLMTLDTIMKCAFSHEGSVQ 207

  Fly   194 MEQRDSSIVQAFRDMCYNINMRAFHPFKRSNRVFSLTPEFSAYQKTLKTLQDFTYDIIEKRVYAL 258
            ::::..|.:||..|:...:..|..:.|.:::.::.::..........|...|.|..:|:.|...|
Mouse   208 LDRKYKSYIQAVEDLNDLVFSRVRNIFHQNDIIYRVSSNGCKANSACKLAHDHTDQVIKSRRIQL 272

  Fly   259 QNGGSKEDHDPSLPRKKMAFLDTLLSSTID-GRPLTRQEIYEEVSTFMFEGHDTTTSGVSFSVYL 322
            |:   :|:.:....::::.|||.||.:.:: |:.|:.:::..||.||||||||||.||:|:..|.
Mouse   273 QD---EEELEKLKKKRRLDFLDILLFARMENGKSLSDKDLRAEVDTFMFEGHDTTASGISWIFYA 334

  Fly   323 LSRHPDVQRKLYREQCEVMGHDMNRSVSFQEIAKMKYLDLFIKEAQRVYPSVPFIGRYCDKDYDI 387
            |:.:|:.|::..:|...::|.  ..|:::.::.||.|..:.||||.|:||.||.:.|........
Mouse   335 LATNPEHQQRCRKEIQSLLGD--GTSITWNDLDKMPYTTMCIKEALRIYPPVPSVSRELSSPVTF 397

  Fly   388 -NGSIVPKGTTLNLALILLGYNDRIFKDPHHFRPERFEEEKPAP------FEYLPFSAGPRNCIG 445
             :|..:|||..:.|:...|.:|..::.:|..|.|.||     ||      ..:||||.|.|||||
Mouse   398 PDGRSLPKGIHVMLSFYGLHHNPTVWPNPEVFDPSRF-----APGSSRHSHSFLPFSGGARNCIG 457

  Fly   446 QKFALLELKTVISKVVRSFEVLPAVDELVSTDGRLNTYLGLAPDEKLKREAGRHKYDPILSAVLT 510
            ::||:.|||..::..:..||:||....:                             ||....:.
Mouse   458 KQFAMNELKVAVALTLLRFELLPDPTRV-----------------------------PIPIPRIV 493

  Fly   511 LKSDNGLHLRLRE 523
            |||.||:||.|::
Mouse   494 LKSKNGIHLHLKK 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	CYP4	68..519	CDD:410721	130/459 (28%)
Cyp4a12a	NP_803125.2	CYP4B-like	70..503	CDD:410771	134/482 (28%)