Protein Alignment Cyp4e3 and CYP4X1

DIOPT Version :10

• Sequence 1: NP_523527.1
• Gene: Cyp4e3 / 34291
• FlyBaseID: FBgn0015035
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_828847.1
• Gene: CYP4X1 / 260293
• HGNCID: 20244
• Length: 509
• Species: Homo sapiens
• Alignment Length: 547
• Identity: 171/547 - (31%)
• Similarity: 268/547 - (48%)
• Gaps: 81/547 - (14%)

  Fly     2 WLAVLALLVLPLITLVYFERKASQRRQLLKEFNGPTPVP----ILGNANRIGKNPAEILSTFFDW 62
            :||.:..|.|.|:..:    |...|||.|.....|.|.|    .||:...|..:..|.|....:
Human    15 YLAFVFCLALGLLQAI----KLYLRRQRLLRDLRPFPAPPTHWFLGHQKFIQDDNMEKLEEIIE- 74

  Fly    63 WYDYGKDNFLFWIG-YSSHIVMTNPKQLEYILN----SQQLIQKSTIYDLLHPWLGHGLLTSFGS 122
              .|.: .|.|||| :.:...:.:|...:.:|:    ..|.:||.:     .|.||.||....|.
Human    75 --KYPR-AFPFWIGPFQAFFCIYDPDYAKTLLSRTDPKSQYLQKFS-----PPLLGKGLAALDGP 131

  Fly   123 KWHKHRKMITPSFHFNILQDFHEVMNENSAKFMTQL--KKASAGDTIIDFQEHANYLTLDVICDT 185
            ||.:||:::||.||||||:.:.||| .:|.|.|...  |..|..||.::..||.|.::||:|...
Human   132 KWFQHRRLLTPGFHFNILKAYIEVM-AHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIMKC 195

  Fly   186 AMGVPINAMEQRDSS---IVQAFRDMCYNINMRAFHPFKRSNRVFSLTPEFSAYQKTLKTLQDFT 247
            |.....|.  |.:|:   ..:|..::...|..|.:.....|:.:|.|:|:...:||..:.|..:|
Human   196 AFSKETNC--QTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYT 258

  Fly   248 YDIIEKRVYALQNGGSKEDHDPSLPRKKMAFLDTLLSSTID-GRPLTRQEIYEEVSTFMFEGHDT 311
            ..||::|..:|| .|.|:|:.|.  ||...|||.:||:..: |...:..:::.|||||:..||||
Human   259 DTIIQERKKSLQ-AGVKQDNTPK--RKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAGHDT 320

  Fly   312 TTSGVSFSVYLLSRHPDVQRKLYREQCEVMGHDMNRSVSFQEIAKMKYLDLFIKEAQRVYPSVPF 376
            ..:.:|:.:|.|:.:|:.|.:...|...::|.  ..|:::.::.:|.|..:.|||..|:.|:||.
Human   321 LAASISWILYCLALNPEHQERCREEVRGILGD--GSSITWDQLGEMSYTTMCIKETCRLIPAVPS 383

  Fly   377 IGRYCDKDYDI-NGSIVPKGTTLNLALILLGYNDRIFKDPHHFRPERFEEE---KPAPFEYLPFS 437
            |.|...|.... :|..:|.|.|:.|::..|.:|..::|:|..|.|.||.:|   :..|:.|||||
Human   384 ISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFS 448

  Fly   438 AGPRNCIGQKFALLELKTVISKVVRSFEVLPAVDELVSTDGRLNTYLGLAPDEKLKREAGRHKYD 502
            ||.||||||:||::|||..|:.::..|.|.|                                 |
Human   449 AGSRNCIGQEFAMIELKVTIALILLHFRVTP---------------------------------D 480

  Fly   503 PILSAVLT------LKSDNGLHLRLRE 523
            |  :..||      ||..||::|.|::
Human   481 P--TRPLTFPNHFILKPKNGMYLHLKK 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	CYP4	68..519	CDD:410721	150/471 (32%)
CYP4X1	NP_828847.1	CYP4B-like	66..502	CDD:410771	153/487 (31%)
		heme binding region	447..460		10/12 (83%)