Protein Alignment Cyp4e3 and Cyp19a1

DIOPT Version :10

• Sequence 1: NP_523527.1
• Gene: Cyp4e3 / 34291
• FlyBaseID: FBgn0015035
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_058781.2
• Gene: Cyp19a1 / 25147
• RGDID: 2457
• Length: 503
• Species: Rattus norvegicus
• Alignment Length: 505
• Identity: 114/505 - (22%)
• Similarity: 219/505 - (43%)
• Gaps: 111/505 - (21%)

  Fly     4 AVLALLVLPLITLVYFERKASQRRQLLKEFNGPTPVPILGNANRIGKNPAEILSTFFDWWYDYGK 68
            |:..||::.|:.|:         |......:.|.|...||    ||    .::|        :|:
  Rat    25 AMPLLLIMGLLLLI---------RNCESSSSIPGPGYCLG----IG----PLIS--------HGR 64

  Fly    69 DNFLFWIGYSSHIVMTNPKQLEYI---LNSQQ--LIQKSTIYDLLHPWLGHGLLTSFGSKWHKHR 128
              || |:|..|.....|....|::   ::.::  :|.||:  .::|.......::.||||    |
  Rat    65 --FL-WMGIGSACNYYNKMYGEFMRVWISGEETLIISKSS--SMVHVMKHSNYISRFGSK----R 120

  Fly   129 KMITPSFHFNILQDFHEVMNENSAKFMTQ---LKKASAG------------------DTIIDFQE 172
            .:.....|.|.:     :.|.|.:.:.|.   ..||..|                  |.:.|..:
  Rat   121 GLQCIGMHENGI-----IFNNNPSLWRTVRPFFMKALTGPGLIRMVEVCVESIKQHLDRLGDVTD 180

  Fly   173 HANY-----LTLDVICDTA----MGVPINAMEQRDSSIVQAFRDMCYNINMRAFHPFK----RSN 224
            ::.|     |...::.||:    :|:|::     :||||:..:..        |:.::    :.|
  Rat   181 NSGYVDVVTLMRHIMLDTSNTLFLGIPLD-----ESSIVKKIQGY--------FNAWQALLIKPN 232

  Fly   225 RVFSLTPEFSAYQKTLKTLQDFTYDIIEKRVYALQNGGSKEDHDPSLPRKKMAFLDTLLSSTIDG 289
            ..|.::..:..|::::|.|:|....::||:...:.:....||        .|.|...|:.:...|
  Rat   233 IFFKISWLYRKYERSVKDLKDEIEILVEKKRQKVSSAEKLED--------CMDFATDLIFAERRG 289

  Fly   290 RPLTRQEIYEEVSTFMFEGHDTTTSGVSFSVYLLSRHPDVQRKLYREQCEVMGHDMNRSVSFQEI 354
             .||::.:.:.:...:....||.:..:...:.|::.:|:|:..:.:|...|:|   :|.:...::
  Rat   290 -DLTKENVNQCILEMLIAAPDTMSVTLYVMLLLIAEYPEVETAILKEIHTVVG---DRDIRIGDV 350

  Fly   355 AKMKYLDLFIKEAQRVYPSVPFIGRYCDKDYDINGSIVPKGTTLNLALILLGYNDRI--FKDPHH 417
            ..:|.::.||.|:.|..|.|..:.|...:|..|:|..|.|||.:   ::.:|...|:  |..|:.
  Rat   351 QNLKVVENFINESLRYQPVVDLVMRRALEDDVIDGYPVKKGTNI---ILNIGRMHRLEYFPKPNE 412

  Fly   418 FRPERFEEEKPAPFEYL-PFSAGPRNCIGQKFALLELKTVISKVVRSFEV 466
            |..|.|  ||..|:.|. ||..|||:|.|:..|::.:|.|:..:::.|.|
  Rat   413 FTLENF--EKNVPYRYFQPFGFGPRSCAGKYIAMVMMKVVLVTLLKRFHV 460

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	CYP4	68..519	CDD:410721	100/441 (23%)
Cyp19a1	NP_058781.2	CYP19A1	72..485	CDD:410709	96/430 (22%)