DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e3 and Cyp4x1

DIOPT Version :9

Sequence 1:	NP_523527.1	Gene:	Cyp4e3 / 34291	FlyBaseID:	FBgn0015035	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_663708.1	Gene:	Cyp4x1 / 246767	RGDID:	628719	Length:	507	Species:	Rattus norvegicus

Alignment Length:	540	Identity:	152/540 - (28%)
Similarity:	263/540 - (48%)	Gaps:	80/540 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LALLVLPLITLVYFERKASQRRQLLKEFNGPTPVPILGNANRIGKNPAEILSTF-------FDWW 63
            |||:::..:.| |..|:...|.  |:.|.|||...:||:...:.::..|.|...       |..|
  Rat    22 LALVLMQAVKL-YLRRQRLLRD--LRPFPGPTAHWLLGHQKFLQEDNMEKLDEIVKEYPCAFPCW 83

  Fly    64 --------YDYGKDNFLFWIGYSSHIVMTNPKQLEYILNSQQLIQKSTIYDLLHPWLGHGLLTSF 120
                    |.|..|....::.      .|:|| .:|            ::.|:.|:||.|||...
  Rat    84 VGPFQAFFYIYDPDYAKIFLS------RTDPK-TQY------------LHQLMTPFLGRGLLNLD 129

  Fly   121 GSKWHKHRKMITPSFHFNILQDFHEVMNENSAKFMTQLKKA-SAGDTIIDFQEHANYLTLDVICD 184
            |.:|.:||.::||:||.:||:...::|..:....:.:.:|. :..:|.|:..||.|.:|||:|..
  Rat   130 GPRWFQHRCLLTPAFHQDILKPCVDMMAHSVNMMLDKWEKTWTTQETTIEVFEHINLMTLDIIMK 194

  Fly   185 TAMGVPINA-MEQRDSSIVQAFRDMCYNINMRAFHPFKRSNRVFSLTPEFSAYQKTLKTLQDFTY 248
            .|.|...|. :.....|.|:|..::...|:.|.::.:...:.:|.|:|:...:|:..|.:...|.
  Rat   195 CAFGQETNCQINGTYESYVKATFELGEIISSRLYNFWHHHDIIFKLSPKGHCFQELGKVIHQCTE 259

  Fly   249 DIIEKRVYALQNGGSKEDHDPSLPRKKMAFLDTLLSSTI-DGRPLTRQEIYEEVSTFMFEGHDTT 312
            .||:.|...|::..:::|...|     ..|||.:||:.. |.:..:..::..||:|||:.|||.:
  Rat   260 KIIQDRKKTLKDQVNQDDTQTS-----QNFLDIVLSAQAGDEKAFSDADLRSEVNTFMWAGHDAS 319

  Fly   313 TSGVSFSVYLLSRHPDVQRKLYREQCEVMGHDMNRSVSFQEIAKMKYLDLFIKEAQRVYPSVPFI 377
            .:.:|:.:|.|:.:|:.|.:...|...::|.  ..|::::::.::.|..:.|||..|:.|.:|.|
  Rat   320 AASISWLLYCLALNPEHQDRCRTEIRSILGD--GSSITWEQLDEIPYTTMCIKETLRLIPPIPSI 382

  Fly   378 GRYCDKDYDI-NGSIVPKGTTLNLALILLGYNDRIFKDPHHFRPERFEEEKPA---PFEYLPFSA 438
            .|...|...: :|..:|.|.|:.|::..|.:|..::|||..|.|.||.:|...   |..:||||:
  Rat   383 SRELSKPLTLPDGHSLPAGMTVVLSIWGLHHNPAVWKDPKVFDPLRFTKENSEQRHPCAFLPFSS 447

  Fly   439 GPRNCIGQKFALLELKTVISKVVRSFEVLPAVDELVSTDGRLNTYLGLAPDEKLKREAGRHKYDP 503
            ||||||||:||:||||..|:..:..|.|  |.|                    |.|       .|
  Rat   448 GPRNCIGQQFAMLELKVAIALTLLRFRV--AAD--------------------LTR-------PP 483

  Fly   504 ILSAVLTLKSDNGLHLRLRE 523
            ..|:...|:..:|::|.|::
  Rat   484 AFSSHTVLRPKHGIYLHLKK 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	p450	35..468	CDD:278495	133/454 (29%)
Cyp4x1	NP_663708.1	CYP4B-like	66..500	CDD:410771	136/488 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348517
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750