DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e3 and Cyp4b1

DIOPT Version :9

Sequence 1:	NP_523527.1	Gene:	Cyp4e3 / 34291	FlyBaseID:	FBgn0015035	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_058695.2	Gene:	Cyp4b1 / 24307	RGDID:	2480	Length:	511	Species:	Rattus norvegicus

Alignment Length:	535	Identity:	158/535 - (29%)
Similarity:	266/535 - (49%)	Gaps:	59/535 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MW--LAVLALLVLPLITLVYFERKASQRRQLLKEFNGPTPVPILGNANRIGKNPAEILSTFFDWW 63
            :|  :.:|.::||.|.:|:...:|.:   :.:..|.||....:.|:|..|.|..:  |.....|.
  Rat    15 LWASVVILMVIVLKLFSLLLRRQKLA---RAMDSFPGPPTHWLFGHALEIQKLGS--LDKVVSWA 74

  Fly    64 YDYGKDNFLFWIGYSSHIVMTNPKQLEY--ILNSQQLIQKSTIYDLLHPWLGHGLLTSFGSKWHK 126
            ..:...:.| |.|  ..:...|..:.:|  .:.|:...:.:.:||....|:|.|||...|.||.:
  Rat    75 QQFPHAHPL-WFG--QFVGFLNIYEPDYAKAVYSRGDPKAADVYDFFLQWIGKGLLVLDGPKWFQ 136

  Fly   127 HRKMITPSFHFNILQDFHEVMNENSAKFMTQLKKASAGDTIIDFQEHANYLTLDVICDTAMGVPI 191
            |||::||.||:::|:.:..:..|::...:.:.:|.::.:...|......::.||.:.....|...
  Rat   137 HRKLLTPGFHYDVLKPYVAIFAESTRMMLDKWEKKASENKSFDIFCDVGHMALDTLMKCTFGKGD 201

  Fly   192 NAMEQRDSSIVQAFRDMCYNINMR----AFHPFKRSNRVFSLTPEFSAYQKTLKTLQDFTYDIIE 252
            :.:..||:|...|..|:...:..|    .:|    ::.::.|||....:.:..|...|.|.::|.
  Rat   202 SGLGHRDNSYYLAVSDLTLLMQQRIDSFQYH----NDFIYWLTPHGRRFLRACKIAHDHTDEVIR 262

  Fly   253 KRVYALQNGGSKEDHDPSLPRKKMAFLDTLLSSTID-GRPLTRQEIYEEVSTFMFEGHDTTTSGV 316
            :|..|||:   :::......|:.:.|||.||....: |..|:..|:..||.|||||||||||||:
  Rat   263 QRKAALQD---EKERKKIQQRRHLDFLDILLGVRDESGIKLSDAELRAEVDTFMFEGHDTTTSGI 324

  Fly   317 SFSVYLLSRHPDVQRKLYREQCEVMGHDMNRSVSFQEIAKMKYLDLFIKEAQRVYPSVPFIGRYC 381
            |:.:|.::.:|:.| :|.||:...:..|.: |..:.::|||.||.:.:||..|:||.||.:.|..
  Rat   325 SWFLYCMALYPEHQ-QLCREEVRGILGDQD-SFQWDDLAKMTYLTMCMKECFRLYPPVPQVYRQL 387

  Fly   382 DKDYD-INGSIVPKGTTLNLALILLGYNDRIFKDPHHFRPERFEEEKPA---PFEYLPFSAGPRN 442
            :|... ::|..:|.|:.::|.:..|..|..::.||..|.|.||..|..|   ||.::||||||||
  Rat   388 NKPVTFVDGRSLPAGSLISLHIYALHRNSTVWPDPEVFDPLRFSPENAAGRHPFAFMPFSAGPRN 452

  Fly   443 CIGQKFALLELKTVISKVVRSFEVLPAVDELVSTDGRLNTYLGLAPDEKLKREAGRHKYDPILSA 507
            ||||:||:.|:|.|.:..:..||                  ..|.|.:.           ||...
  Rat   453 CIGQQFAMNEMKVVTALCLLRFE------------------FSLDPSKM-----------PIKVP 488

  Fly   508 VLTLKSDNGLHLRLR 522
            .|.|:|.||:||.|:
  Rat   489 QLILRSKNGIHLYLK 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	p450	35..468	CDD:278495	138/443 (31%)
Cyp4b1	NP_058695.2	p450	47..500	CDD:278495	147/495 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348661
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.650