Protein Alignment Cyp4e3 and CYP4Z1

DIOPT Version :9

• Sequence 1: NP_523527.1
• Gene: Cyp4e3 / 34291
• FlyBaseID: FBgn0015035
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_835235.1
• Gene: CYP4Z1 / 199974
• HGNCID: 20583
• Length: 505
• Species: Homo sapiens
• Alignment Length: 561
• Identity: 154/561 - (27%)
• Similarity: 265/561 - (47%)
• Gaps: 109/561 - (19%)

  Fly     2 WLAVL-----ALLVLPLITLVYFE--RKASQRRQLLKEFN-GPTPVPILGNANRIGKNPAEILST 58
            ||..|     .||:|..::|:.|:  |...:||.:::..: .|.|             ||.
Human     5 WLQELMAHPFLLLILLCMSLLLFQVIRLYQRRRWMIRALHLFPAP-------------PAH---- 52

  Fly    59 FFDWWYDYGKDNFL--------------------FWIG-----YSSHIVMTNPKQLEYILNSQQL 98
                |: ||...|.                    .|:|     :|.|    :|...:.:|..|.
Human    53 ----WF-YGHKEFYPVKEFEVYHKLMEKYPCAVPLWVGPFTMFFSVH----DPDYAKILLKRQD- 107

  Fly    99 IQKSTI-YDLLHPWLGHGLLTSFGSKWHKHRKMITPSFHFNILQDFHEVMNENSAKFMTQLKKAS 162
             .||.: :.:|..|:|.||:|..||||.|||:::.|.|:.:||:.|..:|:|:....:.:.::..
Human   108 -PKSAVSHKILESWVGRGLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHI 171

  Fly   163 AGDTIIDFQEHANYLTLDVICDTAMGVPINAMEQRDSSIVQAFRDMCYNI----NMRAFHPFKRS 223
            |.::.::..:|.:.:|||.|...|..  .....|.||:: .::....:|:    |.|..:....:
Human   172 AQNSRLELFQHVSLMTLDSIMKCAFS--HQGSIQLDSTL-DSYLKAVFNLSKISNQRMNNFLHHN 233

  Fly   224 NRVFSLTPEFSAYQKTLKTLQDFTYDIIEKRVYALQNGGSKEDHDPSLPRKKMAFLDTLLSSTID 288
            :.||..:.:...:.|..:.|..||..:|:.|..:|:: ..|:|   :..:::..|||.|||:..:
Human   234 DLVFKFSSQGQIFSKFNQELHQFTEKVIQDRKESLKD-KLKQD---TTQKRRWDFLDILLSAKSE 294

  Fly   289 G-RPLTRQEIYEEVSTFMFEGHDTTTSGVSFSVYLLSRHPDVQRKLYREQCEVMGHDMNRSVSFQ 352
            . :..:..::..||.||||.|||||:|.:|:.:|.|:::|:.|::...|..|::|.  ..|::::
Human   295 NTKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGD--GSSITWE 357

  Fly   353 EIAKMKYLDLFIKEAQRVYPSVPFIGRYCDKDYDI-NGSIVPKGTTLNLALILLGYNDRIFKDPH 416
            .:::|.|..:.|||..|:|..|..|.|..||.... :|..:|.|.|:.:.:..|.:|...::||.
Human   358 HLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNPYFWEDPQ 422

  Fly   417 HFRPERF---EEEKPAPFEYLPFSAGPRNCIGQKFALLELKTVISKVVRSFEVLPAVDELVSTDG 478
            .|.|.||   ..||..|:.::|||||.||||||.||::|.|..::..:..|:
Human   423 VFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRFK------------- 474

  Fly   479 RLNTYLGLAPDEKLKREAGRHKYDPILSAVLTLKSDNGLHL 519
                   ||||         |...|.....:.|||.||:|:
Human   475 -------LAPD---------HSRPPQPVRQVVLKSKNGIHV 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	p450	35..468	CDD:278495	131/467 (28%)
CYP4Z1	NP_835235.1	p450	47..500	CDD:278495	143/519 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154705
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D214327at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750