DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e3 and cyp-13A7

DIOPT Version :9

Sequence 1:	NP_523527.1	Gene:	Cyp4e3 / 34291	FlyBaseID:	FBgn0015035	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_496114.1	Gene:	cyp-13A7 / 188362	WormBaseID:	WBGene00000372	Length:	518	Species:	Caenorhabditis elegans

Alignment Length:	496	Identity:	130/496 - (26%)
Similarity:	225/496 - (45%)	Gaps:	91/496 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 KEFNGPTPVPILGNANRIG--KNPAEILSTFFDWWYDYGKDNFLFWI--GYSSHIVMTNPKQLEY 91
            |...||..:|.||..::..  :||..:  .|.:|...||.   ::.|  |....:|:::|:.:..
Worm    29 KGVKGPRGLPFLGVIHKFTNYENPGAL--KFSEWTKKYGP---VYGITEGVEKTLVISDPEFVHE 88

  Fly    92 ILNSQ---------QLIQKSTIYDLLHPWLGHGLLTSFGSKWHKHRKMITPSFHFNILQDFHEVM 147
            :...|         ..||.....:...|     |:.:.|.:|.:.|.:.:|:|....|:.....:
Worm    89 VFVKQFDNFYGRKLTAIQGDPNKNKRVP-----LVAAQGHRWKRLRTLASPTFSNKSLRKIMGTV 148

  Fly   148 NENSAKFMTQLKKASAGDTIIDFQEHANYLTLDVICDTAMG-----VPINAMEQRDSSIVQAFRD 207
            .|:..:.:..|:||||....:|..|:....|:|:|...|||     :..|.|..:..:|.:..|:
Worm   149 EESVTELVRSLEKASAEGKTLDMLEYYQEFTMDIIGKMAMGQEKSLMFRNPMLDKVKTIFKEGRN 213

  Fly   208 MCYNINMRAFHPFK--RSNRVFSLTPEF-------SAYQKTL-KTLQDFTYDIIEKRVYALQNGG 262
            ..:.|:  ...||.  ....:|:..|..       |..:|.| |.|:....|  ||.  .::..|
Worm   214 NVFMIS--GIFPFVGIALRNIFAKFPSLQMATDIQSILEKALNKRLEQREAD--EKA--GIEPSG 272

  Fly   263 SKEDHDPSLPRKKMAFLDTLLS--STID------------------GRPLTRQEIYEEVSTFMFE 307
            ..:|           |:|..|.  ||:|                  .:.||..||..::..|:..
Worm   273 EPQD-----------FIDLFLDARSTVDFFEGEAEQDFAKSEVLKVDKHLTFDEIIGQLFVFLLA 326

  Fly   308 GHDTTTSGVSFSVYLLSRHPDVQRKLYRE---QCEVMGHDMNRSVSFQEIAKMKYLDLFIKEAQR 369
            |:|||...:|:|.|||:.||::|:||..|   :|.      :..|:|.:::|:|||:..:|||.|
Worm   327 GYDTTALSLSYSSYLLATHPEIQKKLQEEVDRECP------DPEVTFDQLSKLKYLECVVKEALR 385

  Fly   370 VYPSVPFI-GRYCDKDYDINGSIVPKGTTLNLALILLGYNDRIF-KDPHHFRPERFEEEKPAPFE 432
            :||....: .|.|.|..::.|..:..||.:|:....|.::.::: .|.:.|:|||:|......|.
Worm   386 LYPLASLVHNRKCLKTTNVLGMEIEAGTNINVDTWSLHHDPKVWGDDVNEFKPERWESGDELFFA 450

  Fly   433 ---YLPFSAGPRNCIGQKFALLELKTVISKVVR--SFEVLP 468
               ||||..|||.|||.:.|::|:|.:::.:::  :||..|
Worm   451 KGGYLPFGMGPRICIGMRLAMMEMKMLLTNILKNYTFETTP 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	p450	35..468	CDD:278495	128/490 (26%)
cyp-13A7	NP_496114.1	p450	33..499	CDD:278495	129/492 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810