Protein Alignment Cyp4e3 and cyp-13A5

DIOPT Version :10

• Sequence 1: NP_523527.1
• Gene: Cyp4e3 / 34291
• FlyBaseID: FBgn0015035
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_496112.1
• Gene: cyp-13A5 / 188356
• WormBaseID: WBGene00011672
• Length: 520
• Species: Caenorhabditis elegans
• Alignment Length: 531
• Identity: 139/531 - (26%)
• Similarity: 233/531 - (43%)
• Gaps: 103/531 - (19%)

  Fly    31 KEFNGPTPVPILGNANRIG--KNPAEILSTFFDWWYDYGKDNFLFWI--GYSSHIVMTNPKQLEY 91
            |...||...|..|..:...  :||.  |....:|..:||.   ::.|  |....::::||:.:..
 Worm    29 KGVKGPRGFPFFGVIHEFQDYENPG--LLKLGEWTKEYGP---IYGITEGVEKTLIVSNPEFVHE 88

  Fly    92 ILNSQ--QLIQKSTIYDLLHPWLG--------HGLLTSFGSKWHKHRKMITPSFHFNILQDFHEV 146
            :...|  ....:.|     :|..|        | |:::.|.:|.:.|.:.:|:|....|:.....
 Worm    89 VFVKQFDNFYGRKT-----NPIQGDPNKNKRAH-LVSAQGHRWKRLRTLSSPTFSNKNLRKIMST 147

  Fly   147 MNENSAKFMTQLKKASAGDTIIDFQEHANYLTLDVICDTAMG-----VPINAMEQRDSSIVQAFR 206
            :.|...:.|..|..|||....:|..::....|||:|...|||     :..|.|..:...|.:..|
 Worm   148 VEETVVELMRHLDDASAKGKAVDLLDYYQEFTLDIIGRIAMGQTESLMFRNPMLPKVKGIFKDGR 212

  Fly   207 DMCYNIN---------MRAFHPFKRSNRVFSLTPEF---SAYQKTL-KTLQDFTYDIIEKRVYAL 258
            .:.:.::         .|.|.     .|..|:.|.|   |..:|.| |.|:....|  ||.  .:
 Worm   213 KLPFLVSGIFPIAGTMFREFF-----MRFPSIQPAFDIMSTVEKALNKRLEQRAAD--EKA--GI 268

  Fly   259 QNGGSKEDHDPSLPRKKMAFLDTLLS--STID------------------GRPLTRQEIYEEVST 303
            :..|..:|           |:|..|.  :.:|                  .:.||..||..::..
 Worm   269 EPSGEPQD-----------FIDLFLDARANVDFFEEESALGFAKTEIAKVDKQLTFDEIIGQLFV 322

  Fly   304 FMFEGHDTTTSGVSFSVYLLSRHPDVQRKLYRE---QCEVMGHDMNRSVSFQEIAKMKYLDLFIK 365
            |:..|:|||...:|:|.|||:|||::|:||..|   :|.      |..|:|.:|:|:||::..:|
 Worm   323 FLLAGYDTTALSLSYSSYLLARHPEIQKKLQEEVDRECP------NPEVTFDQISKLKYMECVVK 381

  Fly   366 EAQRVYPSVPFI-GRYCDKDYDINGSIVPKGTTLNLALILLGYNDRIF-KDPHHFRPERFE---E 425
            ||.|:||....: .|.|.|:.::.|..:.|||.:.:....|.|:.::: :|.:.|||||:|   |
 Worm   382 EALRMYPLASIVHNRKCMKETNVLGVQIEKGTNVQVDTWTLHYDPKVWGEDANEFRPERWESGDE 446

  Fly   426 EKPAPFEYLPFSAGPRNCIGQKFALLELKTVISKVVR--SFEVLPAVDELVSTDGRLNTYLGLAP 488
            ...|...||||..|||.|||.:.|::|.|.:::.:::  :||.....:..:...|...|    ||
 Worm   447 LFYAKGGYLPFGMGPRICIGMRLAMMEKKMLLTHILKKYTFETSTQTEIPLKLVGSATT----AP 507

  Fly   489 DEKLKREAGRH 499
            ...:.:...||
 Worm   508 RSVMLKLTPRH 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	CYP4	68..519	CDD:410721	128/492 (26%)
cyp-13A5	NP_496112.1	CYP3A-like	63..511	CDD:410678	128/486 (26%)