DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e3 and cyp-35D1

DIOPT Version :9

Sequence 1:	NP_523527.1	Gene:	Cyp4e3 / 34291	FlyBaseID:	FBgn0015035	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_507044.1	Gene:	cyp-35D1 / 184495	WormBaseID:	WBGene00008829	Length:	499	Species:	Caenorhabditis elegans

Alignment Length:	506	Identity:	108/506 - (21%)
Similarity:	205/506 - (40%)	Gaps:	84/506 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 VLALLVLPLITLVYFERKASQRRQLLKEFNGPTPVPILGNANRI--------GKNPAEILSTFFD 61
            :|.||.|..||::    .....|::|:...||.|:|::|||::|        |..||      .|
Worm     2 ILILLFLTAITVI----TVRLYRKVLRFPPGPFPLPLIGNAHQIAYQAWRRGGILPA------LD 56

  Fly    62 WWYDYGKDNFLFWIGYSSHIVMTN--PKQLEYILNSQQLIQKSTIYDLLHPWLGHGLLTSFGSKW 124
            ::.....:.:..|:|..:.:.:|:  ..|..::...::...:.....|.|...|.|||.:.|..|
Worm    57 YYRKKYGNAYTLWLGPKASVSITDFETSQEVFVKQGKKCYNRQLAPILEHVTGGVGLLIANGENW 121

  Fly   125 HKHRKMITPSFH-----FNILQDFHEVMNENSAKFMTQLKKASAGDTIIDFQEHANYLTLDV-IC 183
            .:.|:....:|.     .||::  ..:|:|.:.:.:....:.:..|..|          :|| ..
Worm   122 AEMRRFTLLTFRQMGVGTNIME--KRIMDELNGRCLEIDAQIARNDRAI----------VDVKFF 174

  Fly   184 DTAMGVPINAM--------EQRDSSIVQAFRDMCYNIN----------MRAFHPFKRSNRVFSLT 230
            |..:|..||:.        |:....|.:.|.:.....|          ::.|.|.:     |.||
Worm   175 DLTVGSVINSFLIGKRFEDEEEFLKIKKLFDESSETFNIFDLNVPVWFLKTFLPSR-----FKLT 234

  Fly   231 PEFSAYQKTLKTLQDFTYDIIEKRVYALQNGGSKEDHDPSLPRKKMAFLDTLLSSTIDGRPLT-R 294
            .: |.:|     :.|.....:|:|:..:::|..|.|     |:|....:|..||.......:. .
Worm   235 WD-SRHQ-----IMDHVMKGVEERIRDIESGAYKID-----PKKPNDVVDAFLSKMKKEEEIAGG 288

  Fly   295 QEIYEEVSTFMFEGHD-------TTTSGVSFSVYLLSRHPDVQRKLYREQCEVMGHDMNRSVSFQ 352
            |..|..:.:.....||       ||.:.:......|..||.:.:.:.:|..::..:.. |.::.:
Worm   289 QHPYYNLKSLKLVLHDLWLAGQGTTATTLYVGFMKLVNHPGIIQNIQKELLDITENGA-RDLTLK 352

  Fly   353 EIAKMKYLDLFIKEAQRVYPSVPFIG--RYCDKDYDINGSIVPKGTTLNLALILLGYNDRIFKDP 415
            :.....||:..|.|.|| :.|:..:.  |...:....|...|..||.:...:.:|..|:.:|.:|
Worm   353 DRPNTPYLNATIAEIQR-HASILNVNFWRINHETIHFNDYQVDPGTMIAAQVGVLHVNEELFDNP 416

  Fly   416 HHFRPERFEEEKPAPFEYLPFSAGPRNCIGQKFALLELKTVISKVVRSFEV 466
            ..|..|::.:......:.:||..|.|:|:|::.|..||..|...::..:.|
Worm   417 KDFNVEKYLKNPKLLQQVIPFGIGKRSCVGEQIAKSELYLVFGNILLRYNV 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	p450	35..468	CDD:278495	100/476 (21%)
cyp-35D1	NP_507044.1	p450	35..496	CDD:299894	96/469 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010