Protein Alignment Cyp4e3 and cyp-25A2

DIOPT Version :10

• Sequence 1: NP_523527.1
• Gene: Cyp4e3 / 34291
• FlyBaseID: FBgn0015035
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_497776.2
• Gene: cyp-25A2 / 175495
• WormBaseID: WBGene00007964
• Length: 502
• Species: Caenorhabditis elegans
• Alignment Length: 485
• Identity: 146/485 - (30%)
• Similarity: 232/485 - (47%)
• Gaps: 44/485 - (9%)

  Fly     4 AVLALLVLPLITLVYFERKASQRRQLLKEFNGPTPVPILGNANRIGKNPAEILSTFFDWWYD--- 65
            ::|.|||..:|.:::..|:..:.|:.: ...||.|...:||..:|.....::.....:.|::
 Worm     8 SILILLVSFIIYILFARREQFKLREKI-GLTGPEPHWFMGNLKQIVDRKEKLGYDDSNKWFNELH 71

  Fly    66 --YGKDNFLFWIGYSSHIVMTNPKQLE--YILN----SQQLIQKSTIYDLLHPWLGHGLL-TSFG 121
              || :.|..:.|...:||::|.:.::  :|.|    |.:::  ..|:|  ...|...|| .::.
 Worm    72 KQYG-ETFGIYFGAQMNIVLSNEEDIKEVFIKNFSNFSDRIV--PPIFD--SNQLNQSLLQNTYA 131

  Fly   122 SKWHKHRKMITPSFHFNILQDFHEVMNENSAKFMTQLK-KASAG---DTIIDFQEHANYLTLDVI 182
            :.|...|..|.|.|....::...|.::.....|:..|: |||:|   |...|||.    ||||||
 Worm   132 TGWKHTRSAIAPIFSTGKMKAMQETIHSKVDLFLDILREKASSGQKWDIYEDFQG----LTLDVI 192

  Fly   183 CDTAMGVPINAMEQRDSSIVQAFRDMCYNINMRAFHPFKRSNRVFSLTPEFSAYQKTLKTLQDFT 247
            ...|..:..|....|:.......|....||::|.......|..:..|.|.:.|..| ...|.|..
 Worm   193 GKCAFAIDSNCQRDRNDVFYVNARKFIANIDIRHSKVIAASFILPELAPLWRALYK-YTPLADAE 256

  Fly   248 YDIIE--KRVYALQNGGSKEDHDPSLPRKKMAFLDTLLSSTID-GRPLTRQEIYEEVSTFMFEGH 309
            ..::|  ..||..:.||...|        .:..|..||:...| .:|:|:||:.|....|:..|:
 Worm   257 IPLVEGLSNVYERRRGGEGSD--------SVDLLKLLLNREDDKSKPMTKQEVIENCFAFLLAGY 313

  Fly   310 DTTTSGVSFSVYLLSRHPDVQRKLYREQCEVMGHDMNRSVSFQEIAKMKYLDLFIKEAQRVYPSV 374
            :||::.:::..||||::|:||:|||.   |:|....|..:::..|..|||||...||..|.||.|
 Worm   314 ETTSTAMTYCSYLLSKYPNVQQKLYE---EIMEAKENGGLTYDSIHNMKYLDYVYKETLRCYPPV 375

  Fly   375 -PFIGRYCDKDYDINGSIVPKGTTLNLALILLGYNDRIFKDPHHFRPERFE--EEKPAPFEYLPF 436
             .||.|.|..|..|.|...|||:.:......:..|...:..|..|.|||||  |||.:..:::||
 Worm   376 IHFINRRCLADITIRGQFYPKGSVVTCLPHTVHLNPENWDSPEEFHPERFENWEEKSSSLKWIPF 440

  Fly   437 SAGPRNCIGQKFALLELKTVISKVVRSFEV 466
            ..|||.|:|.:||.:|.||.|.|::.:||:
 Worm   441 GVGPRYCVGMRFAEMEFKTTIVKLLDTFEL 470

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	CYP4	68..519	CDD:410721	130/416 (31%)
cyp-25A2	NP_497776.2	CYP3A-like	73..495	CDD:410678	132/419 (32%)