DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e3 and Cyp4f13

DIOPT Version :9

Sequence 1:	NP_523527.1	Gene:	Cyp4e3 / 34291	FlyBaseID:	FBgn0015035	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_570952.1	Gene:	Cyp4f13 / 170716	MGIID:	2158641	Length:	523	Species:	Mus musculus

Alignment Length:	484	Identity:	146/484 - (30%)
Similarity:	249/484 - (51%)	Gaps:	48/484 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 KNPAEILSTFFDWWYDYGKDNFLFWIGYSSHIV-MTNPKQLEYILNSQQLI--QKSTIYDLLHPW 111
            ||..|.:.......:|: .|..|.|:|....|: :.:|..:..:|.:...:  ::.|:|..|.||
Mouse    68 KNNEESMQFITHLGHDF-HDVHLSWVGPVYPILRLVHPNFIAPLLQASAAVAPKEMTLYGFLKPW 131

  Fly   112 LGHGLLTSFGSKWHKHRKMITPSFHFNILQDFHEVMNEN----SAKFMTQLKKASAGDTIIDFQE 172
            ||.|||.|.|.||..||:::||:|||:||:.:.::.|::    .||:..   .||.|.:.:|..|
Mouse   132 LGDGLLMSAGDKWSHHRRLLTPAFHFDILKSYVKIFNKSVNIMHAKWQC---LASKGTSRLDMFE 193

  Fly   173 HANYLTLDVICDTAMGVPINAMEQRDSSIVQAFRDMCYNINMRAFHPFKRSNRVFSLTPEFSAYQ 237
            |.:.:|||.:......|..|..|. ||..:.|..::...:..|...||...:.::.||.:...::
Mouse   194 HISLMTLDSLQKCIFSVDSNCQES-DSKYIAAILELSSLVVKRHRQPFLYLDLLYYLTADGRRFR 257

  Fly   238 KTLKTLQDFTYDIIEKRVYALQNGGSKEDHDPSLPRKKMAFLDTLLSSTID-GRPLTRQEIYEEV 301
            |....:.:||..:|::|...|...| .|........|.:.|:|.||.:..: |:.|:.::|..|.
Mouse   258 KACDLVHNFTDAVIKERRSTLNTQG-VEFLKAKAKTKTLDFIDVLLMAEDEHGKGLSNEDIRAEA 321

  Fly   302 STFMFEGHDTTTSGVSFSVYLLSRHPDVQRKLYREQCEVMGHDMNRSVSFQEIAKMKYLDLFIKE 366
            .||||.|||||||.:|:.:|.|:|||:.|.:..:|..|::....:..:.:.::|::.:|.:.|||
Mouse   322 DTFMFGGHDTTTSALSWILYNLARHPEYQERCRQEVQELLRDRDSEEIEWDDLAQLPFLTMCIKE 386

  Fly   367 AQRVYPSVPFIGRYCDKDYDI-NGSIVPKGTTLNLALILLGYNDRIFKDPHHFRPERFEEEKP-- 428
            :.|::|.|..|.|.|.:|..: :|..:|||....:::..:.:|..::.||..:.|.||:.|.|
Mouse   387 SLRLHPPVLLISRCCTQDVLLPDGRAIPKGNICVISIFGVHHNPSVWPDPEVYNPFRFDPENPQK 451

  Fly   429 -APFEYLPFSAGPRNCIGQKFALLELKTVISKVVRSFEVLPAVDELVSTDGRLNTYLGLAPDEKL 492
             :|..::|||||.||||||.||:.|:|..::..:..|.:|                    ||:|
Mouse   452 RSPLAFIPFSAGTRNCIGQTFAMSEIKVALALTLLRFRIL--------------------PDDK- 495

  Fly   493 KREAGRHKYDPILSAVLTLKSDNGLHLRL 521
                     :|.....|.|:::.||.||:
Mouse   496 ---------EPRRKPELILRAEGGLWLRV 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	p450	35..468	CDD:278495	135/429 (31%)
Cyp4f13	NP_570952.1	p450	52..513	CDD:278495	144/480 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845165
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.650