Protein Alignment Cyp4e3 and CYP26A1

DIOPT Version :10

• Sequence 1: NP_523527.1
• Gene: Cyp4e3 / 34291
• FlyBaseID: FBgn0015035
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_000774.2
• Gene: CYP26A1 / 1592
• HGNCID: 2603
• Length: 497
• Species: Homo sapiens
• Alignment Length: 423
• Identity: 100/423 - (23%)
• Similarity: 174/423 - (41%)
• Gaps: 77/423 - (18%)

  Fly    77 YSSHI-------VMTNPKQLEYILNSQQLIQKSTIYDLLHPW-------LGHGLLTSFGSKWHKH 127
            |.:|:       ||........:|...:|:.       :| |       ||.|.|::.....||.
Human    79 YKTHLFGRPTVRVMGADNVRRILLGEHRLVS-------VH-WPASVRTILGSGCLSNLHDSSHKQ 135

  Fly   128 R-KMITPSFHFNILQDFHEVMNENSAKFMTQLKKASAGDTIIDFQEHANYLTLDVICDTAMGVPI 191
            | |:|..:|....|:.:..|:.|.....:.|.  .|.|:..:........|...:.....:|...
Human   136 RKKVIMRAFSREALECYVPVITEEVGSSLEQW--LSCGERGLLVYPEVKRLMFRIAMRILLGCEP 198

  Fly   192 NAMEQRDS--SIVQAFRDMCYNINMRAFHPFKRSNRVFSLTPE--FSAYQKTLKTLQDFTYDIIE 252
            ......||  .:|:||.:|..|:              |||..:  ||...:.:|. ::..:..||
Human   199 QLAGDGDSEQQLVEAFEEMTRNL--------------FSLPIDVPFSGLYRGMKA-RNLIHARIE 248

  Fly   253 KRVYALQNG--------GSKEDHDPSLPRKKMAFLDTLLSSTID-GRPLTRQEIYEEVSTFMFEG 308
            :.:.|...|        |.|:            .|..|:..:.: |..|..|.:.:..:..:|.|
Human   249 QNIRAKICGLRASEAGQGCKD------------ALQLLIEHSWERGERLDMQALKQSSTELLFGG 301

  Fly   309 HDTTTSGVSFSVYLLSRHPDVQRKLYREQCEVMG----HDMNRSVSFQEIAKMKYLDLFIKEAQR 369
            |:||.|..:..:..|..:|.|.:|: ||:.:..|    .:.:..:..:.:.::||:...|||..|
Human   302 HETTASAATSLITYLGLYPHVLQKV-REELKSKGLLCKSNQDNKLDMEILEQLKYIGCVIKETLR 365

  Fly   370 VYPSVPFIGRYCDKDYDINGSIVPKGTTLNLALILLGYND--RIFKDPHHFRPERF---EEEKPA 429
            :.|.||...|...|.:::||..:|||  .|:...:...:|  .||.:...|.|:||   ..|..:
Human   366 LNPPVPGGFRVALKTFELNGYQIPKG--WNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPEDAS 428

  Fly   430 PFEYLPFSAGPRNCIGQKFALLELKTVISKVVR 462
            .|.::||..|.|:|:|::||.:.||....::.|
Human   429 RFSFIPFGGGLRSCVGKEFAKILLKIFTVELAR 461

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	CYP4	68..519	CDD:410721	100/423 (24%)
CYP26A1	NP_000774.2	CYP26A1	55..490	CDD:410731	100/423 (24%)