Protein Alignment Cyp4e3 and CYP19A1

DIOPT Version :9

• Sequence 1: NP_523527.1
• Gene: Cyp4e3 / 34291
• FlyBaseID: FBgn0015035
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_000094.2
• Gene: CYP19A1 / 1588
• HGNCID: 2594
• Length: 503
• Species: Homo sapiens
• Alignment Length: 529
• Identity: 121/529 - (22%)
• Similarity: 221/529 - (41%)
• Gaps: 120/529 - (22%)

  Fly     8 LLVLPLITLVYFERKASQRRQLLKEFNGPTPVPILGNANRIGKNPAEILSTFFDWWYDYGKDNFL 72
            ||:..|..||:             .:.|.:.:|..|....||    .::|        :|:  ||
Human    29 LLLTGLFLLVW-------------NYEGTSSIPGPGYCMGIG----PLIS--------HGR--FL 66

  Fly    73 FWIGYSSHIVMTNPKQLEYI---LNSQQ--LIQKSTIYDLLHPWLGHGLLTSFGSKW-----HKH 127
             |:|..|.....|....|::   ::.::  :|.||:  .:.|....:...:.||||.     ..|
Human    67 -WMGIGSACNYYNRVYGEFMRVWISGEETLIISKSS--SMFHIMKHNHYSSRFGSKLGLQCIGMH 128

  Fly   128 RKMITPSFHFNILQDFHEVMNENSAKFMTQ---LKKASAG------------------DTIIDFQ 171
            .|.|              :.|.|...:.|.   ..||.:|                  |.:.:..
Human   129 EKGI--------------IFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVT 179

  Fly   172 EHANY---LTL--DVICDTA----MGVPINAMEQRDSSIV---QAFRDMCYNINMRAFHPFKRSN 224
            ..:.|   |||  .|:.||:    :.:|::     :|:||   |.:.|....:.:       :.:
Human   180 NESGYVDVLTLLRRVMLDTSNTLFLRIPLD-----ESAIVVKIQGYFDAWQALLI-------KPD 232

  Fly   225 RVFSLTPEFSAYQKTLKTLQDFTYDIIEKRVYALQNGGSKEDHDPSLPRKKMAFLDTLLSSTIDG 289
            ..|.::..:..|:|::|.|:|....:|.::...:......|:        .|.|...|:.:...|
Human   233 IFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEE--------CMDFATELILAEKRG 289

  Fly   290 RPLTRQEIYEEVSTFMFEGHDTTTSGVSFSVYLLSRHPDVQRKLYREQCEVMGHDMNRSVSFQEI 354
             .|||:.:.:.:...:....||.:..:.|.::|:::||:|:..:.:|...|:|   .|.:...:|
Human   290 -DLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIG---ERDIKIDDI 350

  Fly   355 AKMKYLDLFIKEAQRVYPSVPFIGRYCDKDYDINGSIVPKGTTLNLALILLGYNDRI--FKDPHH 417
            .|:|.::.||.|:.|..|.|..:.|...:|..|:|..|.|||.:   ::.:|...|:  |..|:.
Human   351 QKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNI---ILNIGRMHRLEFFPKPNE 412

  Fly   418 FRPERFEEEKPAPFEYL-PFSAGPRNCIGQKFALLELKTVISKVVRSFEVLPAVDELVSTDGRLN 481
            |..|.|  .|..|:.|. ||..|||.|.|:..|::.:|.::..::|.|.|.....:.|.:..:::
Human   413 FTLENF--AKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIH 475

  Fly   482 TYLGLAPDE 490
            . |.|.|||
Human   476 D-LSLHPDE 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	p450	35..468	CDD:278495	110/478 (23%)
CYP19A1	NP_000094.2	CYP19A1	72..485	CDD:410709	105/458 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154809
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.950