Protein Alignment Cyp4e3 and CYP4B1

DIOPT Version :9

• Sequence 1: NP_523527.1
• Gene: Cyp4e3 / 34291
• FlyBaseID: FBgn0015035
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_001093242.1
• Gene: CYP4B1 / 1580
• HGNCID: 2644
• Length: 512
• Species: Homo sapiens
• Alignment Length: 540
• Identity: 156/540 - (28%)
• Similarity: 257/540 - (47%)
• Gaps: 68/540 - (12%)

  Fly     1 MWLAVLALLVLPLITLVYFERKASQRRQLLKEFNGPTPVPILGNANRIGKNPAEILSTFFDWWYD 65
            :|.:.| :|||..:.|::...:.....:.:.:|.||....:.|:|..|.:..:  |.....|.:.
Human    15 LWASGL-ILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALEIQETGS--LDKVVSWAHQ 76

  Fly    66 YGKDNFLFWIGYSSHIVMTNPKQLEY--ILNSQQLIQKSTIYDLLHPWLGHGLLTSFGSKWHKHR 128
            :...:.| |.|  ..|...|..:.:|  .:.|:...:...:||....|:|.|||...|.||.:||
Human    77 FPYAHPL-WFG--QFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQWIGRGLLVLEGPKWLQHR 138

  Fly   129 KMITPSFHFNILQDFHEVMNENSA----KFMTQLKKASAGDTIIDFQEHANYLTLDVI--C---- 183
            |::||.||:::|:.:..|..|::.    |:..:.::..:.|...|    ..::.|:.:  |
Human   139 KLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCD----VGHMALNTLMKCTFGR 199

  Fly   184 -DTAMGVPINAMEQRDSSIVQAFRDMCYNINMRAFHPFKRSNRVFSLTPEFSAYQKTLKTLQDFT 247
             ||.:|      ..||||...|..|:...:..|.......::.::.|||....:.:..:...|.|
Human   200 GDTGLG------HSRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHT 258

  Fly   248 YDIIEKRVYALQNGGSKEDHDPSLPRKKMAFLDTLLSS-TIDGRPLTRQEIYEEVSTFMFEGHDT 311
            ..:|.:|..|||:   ::.......|:.:.|||.||.: ..|...|:..::..||.|||||||||
Human   259 DQVIRERKAALQD---EKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDT 320

  Fly   312 TTSGVSFSVYLLSRHPDVQRKLYREQCEVMGHDMNRSVSFQEIAKMKYLDLFIKEAQRVYPSVPF 376
            ||||:|:.:|.::.:|:.|.:...|..|::| |.: ...:.::.||.||.:.|||:.|:||.||.
Human   321 TTSGISWFLYCMALYPEHQHRCREEVREILG-DQD-FFQWDDLGKMTYLTMCIKESFRLYPPVPQ 383

  Fly   377 IGRYCDKDYD-INGSIVPKGTTLNLALILLGYNDRIFKDPHHFRPERFEEE---KPAPFEYLPFS 437
            :.|...|... ::|..:|.|:.:::.:..|..|..::.||..|...||..|   |..||.::|||
Human   384 VYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFS 448

  Fly   438 AGPRNCIGQKFALLELKTVISKVVRSFEVLPAVDELVSTDGRLNTYLGLAPDEKLKREAGRHKYD 502
            |||||||||:||:.|:|.|.:..:..||                  ..|.|...
Human   449 AGPRNCIGQQFAMSEMKVVTAMCLLRFE------------------FSLDPSRL----------- 484

  Fly   503 PILSAVLTLKSDNGLHLRLR 522
            ||....|.|:|.||.||.|:
Human   485 PIKMPQLVLRSKNGFHLHLK 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	p450	35..468	CDD:278495	137/450 (30%)
CYP4B1	NP_001093242.1	p450	47..501	CDD:306555	146/502 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154797
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.650