Protein Alignment Cyp4e3 and CYP3A4

DIOPT Version :9

• Sequence 1: NP_523527.1
• Gene: Cyp4e3 / 34291
• FlyBaseID: FBgn0015035
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_059488.2
• Gene: CYP3A4 / 1576
• HGNCID: 2637
• Length: 503
• Species: Homo sapiens
• Alignment Length: 543
• Identity: 137/543 - (25%)
• Similarity: 246/543 - (45%)
• Gaps: 84/543 - (15%)

  Fly     2 WLAVLALLVLPLITLVYFERKASQRRQLLKEFN--GPTPVPILGNANRIGKNPAEILS-----TF 59
            ||    ||.:.|:.|..:   .:....|.|:..  ||||:|.|||          |||     ..
Human    12 WL----LLAVSLVLLYLY---GTHSHGLFKKLGIPGPTPLPFLGN----------ILSYHKGFCM 59

  Fly    60 FDW--WYDYGKDNFLFWIGYSSHIVMTNPKQLEYILNSQQLIQKSTIYDLLHPWLGHGLLTSFGS 122
            ||.  ...||| .:.|:.|....:.:|:|..::.:|    :.:..:::....|:...|.:.|..|
Human    60 FDMECHKKYGK-VWGFYDGQQPVLAITDPDMIKTVL----VKECYSVFTNRRPFGPVGFMKSAIS 119

  Fly   123 -----KWHKHRKMITPSFHFNILQDFHEVMNENSAKFMTQLKKASAGDTIIDFQEHANYLTLDVI 182
                 :|.:.|.:::|:|....|::...::.:.....:..|::.:.....:..::.....::|||
Human   120 IAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVI 184

  Fly   183 CDTAMGVPINAMEQRDSSIVQAFRDMCYNINMRAFHPFKRSNRVFS-LTPEFSAYQKTLKTLQDF 246
            ..|:.||.|:::.......|:..:.:   :......||..|..||. |.|       .|:.|...
Human   185 TSTSFGVNIDSLNNPQDPFVENTKKL---LRFDFLDPFFLSITVFPFLIP-------ILEVLNIC 239

  Fly   247 TY-----DIIEKRVYALQNGGSKEDHDPSLPRKKMAFLDTLLSS-----TIDGRPLTRQEIYEEV 301
            .:     :.:.|.|..:     ||.......:.::.||..::.|     |...:.|:..|:..:.
Human   240 VFPREVTNFLRKSVKRM-----KESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQS 299

  Fly   302 STFMFEGHDTTTSGVSFSVYLLSRHPDVQRKLYREQCEVMGHDMNRSVSFQEIAKMKYLDLFIKE 366
            ..|:|.|::||:|.:||.:|.|:.|||||:||..|...|:.:  ....::..:.:|:|||:.:.|
Human   300 IIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPN--KAPPTYDTVLQMEYLDMVVNE 362

  Fly   367 AQRVYPSVPFIGRYCDKDYDINGSIVPKGTTLNLALILLGYNDRIFKDPHHFRPERFEEEKP--- 428
            ..|::|....:.|.|.||.:|||..:|||..:.:....|..:.:.:.:|..|.||||.::..
Human   363 TLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNI 427

  Fly   429 APFEYLPFSAGPRNCIGQKFALLELKTVISKVVRSFEVLPAVDELVSTDGRLNTYLGLAPDEKLK 493
            .|:.|.||.:|||||||.:|||:.:|..:.:|:::|...|..:..:.....|.   ||...||
Human   428 DPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG---GLLQPEK-- 487

  Fly   494 REAGRHKYDPILSAVLTLKSDNG 516
                     |:   ||.::|.:|
Human   488 ---------PV---VLKVESRDG 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	p450	35..468	CDD:278495	118/458 (26%)
CYP3A4	NP_059488.2	p450	39..493	CDD:365848	127/502 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810