DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e3 and CYP3A7

DIOPT Version :9

Sequence 1:	NP_523527.1	Gene:	Cyp4e3 / 34291	FlyBaseID:	FBgn0015035	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_000756.3	Gene:	CYP3A7 / 1551	HGNCID:	2640	Length:	503	Species:	Homo sapiens

Alignment Length:	523	Identity:	130/523 - (24%)
Similarity:	246/523 - (47%)	Gaps:	67/523 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WLAVLALLVLPLITLVYFERKASQRRQLLKEFN--GPTPVPILGNANRIGKNPAEILSTFFDWWY 64
            ||    ||.:.||.|..:   .::...|.|:..  ||||:|.||||....|.         .|.:
Human    12 WL----LLAVSLILLYLY---GTRTHGLFKKLGIPGPTPLPFLGNALSFRKG---------YWTF 60

  Fly    65 D------YGKDNFLFWIGYSSH---IVMTNPKQLEYILNSQQLIQKSTIYDLLHP-----WLGHG 115
            |      |.|    .|..|...   :.:|:|..::.:|    :.:..:::....|     ::.:.
Human    61 DMECYKKYRK----VWGIYDCQQPMLAITDPDMIKTVL----VKECYSVFTNRRPFGPVGFMKNA 117

  Fly   116 LLTSFGSKWHKHRKMITPSFHFNILQDFHEVMNENSAKFMTQLKKASAGDTIIDFQEHANYLTLD 180
            :..:...:|.:.|.:::|:|....|::...::.:.....:..|::.:.....:..:......::|
Human   118 ISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMD 182

  Fly   181 VICDTAMGVPINAMEQRDSSIVQAFRDMCYNINMRAFHPFKRSNRVFS-LTPEFSAYQKTLKTLQ 244
            ||..|:.||.|:::.......|:..:.:   :......||..|.:||. |||...|...|:...:
Human   183 VITSTSFGVSIDSLNNPQDPFVENTKKL---LRFNPLDPFVLSIKVFPFLTPILEALNITVFPRK 244

  Fly   245 DFTYDIIEKRVYALQNGGSKEDHDPSLPRKKMAFLDTLLSS-----TIDGRPLTRQEIYEEVSTF 304
            ..::  :.|.|..::.|..||..     :.::.||..::.|     :...:.|:..|:..:...|
Human   245 VISF--LTKSVKQIKEGRLKETQ-----KHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIF 302

  Fly   305 MFEGHDTTTSGVSFSVYLLSRHPDVQRKLYREQCEVMGHDMNRSVSFQEIAKMKYLDLFIKEAQR 369
            :|.|::||:|.:||.:|.|:.|||||:|:.:|...|:.:  ....::..:.:::|||:.:.|..|
Human   303 IFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPN--KAPPTYDTVLQLEYLDMVVNETLR 365

  Fly   370 VYPSVPFIGRYCDKDYDINGSIVPKGTTLNLALILLGYNDRIFKDPHHFRPERFEEEKP---APF 431
            ::|....:.|.|.||.:|||..:|||..:.:...:|.::.:.:.:|..|.||||.::..   .|:
Human   366 LFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPY 430

  Fly   432 EYLPFSAGPRNCIGQKFALLELKTVISKVVRSFEVLPAVDELVSTDGRLNTYLGLAPDEK---LK 493
            .|.||.:|||||||.:|||:.:|..:.:|:::|...|..:..:....|..   ||...||   ||
Human   431 IYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFG---GLLLTEKPIVLK 492

  Fly   494 REA 496
            .|:
Human   493 AES 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	p450	35..468	CDD:278495	112/455 (25%)
CYP3A7	NP_000756.3	p450	39..492	CDD:365848	118/484 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810