DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4e3 and Cyp4b1

DIOPT Version :9

Sequence 1:	NP_523527.1	Gene:	Cyp4e3 / 34291	FlyBaseID:	FBgn0015035	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_031849.1	Gene:	Cyp4b1 / 13120	MGIID:	103225	Length:	511	Species:	Mus musculus

Alignment Length:	535	Identity:	155/535 - (28%)
Similarity:	264/535 - (49%)	Gaps:	59/535 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWLAVLALL--VLPLITLVYFERKASQRRQLLKEFNGPTPVPILGNANRIGKNPAEILSTFFDWW 63
            :|.:|:.|:  ||.|::|::..:|.:   :.|..|.||....:.|:|..|.|...  |.....|.
Mouse    15 LWASVVILMVTVLKLLSLLFRRQKLA---RALDSFPGPPKHWLFGHALEIQKTGG--LDKVVTWT 74

  Fly    64 YDYGKDNFLFWIGYSSHIVMTNPKQLEY--ILNSQQLIQKSTIYDLLHPWLGHGLLTSFGSKWHK 126
            ..:...:.| |:|  ..||..|..:.:|  .:.|:...:.:.:||....|:|.|||...|.||.:
Mouse    75 EQFPYAHPL-WLG--QFIVFLNIYEPDYAKAVYSRGDPKAAYVYDFFLQWIGKGLLVLEGPKWFQ 136

  Fly   127 HRKMITPSFHFNILQDFHEVMNENSAKFMTQLKKASAGDTIIDFQEHANYLTLDVICDTAMGVPI 191
            |||::||.||:::|:.:..:..|::...:.:.:|.::.:...|......::.||.:.....|...
Mouse   137 HRKLLTPGFHYDVLKPYVAIFAESTRVMLDKWEKKASENKSFDIFCDVGHMALDTLMKCTFGKGD 201

  Fly   192 NAMEQRDSSIVQAFRDMCYNINMR----AFHPFKRSNRVFSLTPEFSAYQKTLKTLQDFTYDIIE 252
            :.:...|:|...|..|:...:..|    .:|    ::.::.|||....:.:..:...|.|..:|.
Mouse   202 SGLSHSDNSYYLAVSDLTLLMQQRIDSFQYH----NDFIYWLTPHGRRFLRACQIAHDHTDHVIR 262

  Fly   253 KRVYALQNGGSKEDHDPSLPRKKMAFLDTLLSSTID-GRPLTRQEIYEEVSTFMFEGHDTTTSGV 316
            :|..|||:   :::......|:.:.|||.||.:..: |..|:..::..||.|||||||||||||:
Mouse   263 QRKAALQD---EKEQKKLQERRHLDFLDILLGARDESGIKLSDADLRAEVDTFMFEGHDTTTSGI 324

  Fly   317 SFSVYLLSRHPDVQRKLYREQCEVMGHDMNRSVSFQEIAKMKYLDLFIKEAQRVYPSVPFIGRYC 381
            |:.:|.::.:|..|::...|..|::|.  ..|..:.::|:|.||.:.:||..|:||.||.:.|..
Mouse   325 SWFLYCMALYPMHQQRCREEVREILGD--RDSFQWDDLAQMTYLTMCMKECFRLYPPVPQVYRQL 387

  Fly   382 DKDYD-INGSIVPKGTTLNLALILLGYNDRIFKDPHHFRPERFEEEKPA---PFEYLPFSAGPRN 442
            .|... ::|..:|.|:.::|.:..|..|..::.||..|.|.||..|...   ||.::||||||||
Mouse   388 SKPVTFVDGRSLPAGSLISLHIYALHRNSAVWPDPEVFDPLRFSPENMTGRHPFAFMPFSAGPRN 452

  Fly   443 CIGQKFALLELKTVISKVVRSFEVLPAVDELVSTDGRLNTYLGLAPDEKLKREAGRHKYDPILSA 507
            ||||:||:.|:|.|.:..:..||..|...::                             ||...
Mouse   453 CIGQQFAMNEMKVVTALCLLRFEFSPDPSKI-----------------------------PIKVP 488

  Fly   508 VLTLKSDNGLHLRLR 522
            .|.|:|.||:||.|:
Mouse   489 QLILRSKNGIHLYLK 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	p450	35..468	CDD:278495	134/443 (30%)
Cyp4b1	NP_031849.1	p450	47..500	CDD:278495	142/495 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845250
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.650