DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e3 and Cyp4a12b

DIOPT Version :9

Sequence 1:	NP_523527.1	Gene:	Cyp4e3 / 34291	FlyBaseID:	FBgn0015035	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_758510.2	Gene:	Cyp4a12b / 13118	MGIID:	3611747	Length:	508	Species:	Mus musculus

Alignment Length:	533	Identity:	145/533 - (27%)
Similarity:	259/533 - (48%)	Gaps:	69/533 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VLPLITLVYFERKASQRRQLL----KEFNGPTPVPILGNANRIGKNPAEILSTFFDW------WY 64
            ||.|:.|::...:....||.|    ::|..|....:.|:.....::..:||:...::      |
Mouse    24 VLSLLLLLFKTAQLYLHRQWLLSSTQQFPSPPSHWLFGHKILKDQDLQDILTRIKNFPSACPQW- 87

  Fly    65 DYGKDNFLFWIGYSSHIVMTNPKQLEYILNSQQLIQKSTIYDLLHPWLGHGLLTSFGSKWHKHRK 129
                    .| |....|.:.:|..::.||.........: |..|.||:|.|||...|..|.:||:
Mouse    88 --------LW-GSKVRIQVYDPDYMKLILGRSDPKAHGS-YRFLAPWIGRGLLLLDGQTWFQHRR 142

  Fly   130 MITPSFHFNILQDFHEVMNENSAKFMTQLKKASAGDTIIDFQEHANYLTLDVICDTAMGVPINA- 193
            |:||:||::||:.:.|:|.::....:.:.::....|:.::..:|...:|||.|...|.....:.
Mouse   143 MLTPAFHYDILKPYTEIMADSVHVMLDKWEQIVGQDSTLEIFQHITLMTLDTIMKCAFSHEGSVQ 207

  Fly   194 MEQRDSSIVQAFRDMCYNINMRAFHPFKRSNRVFSLTPEFSAYQKTLKTLQDFTYDIIEKRVYAL 258
            ::::..|.:||..|:.....:|..:.|.:::.::.::..........:...|.|..:|:.|...|
Mouse   208 LDRKYKSYIQAVEDLNNLFFLRVRNIFHQNDIIYRVSSNGCLANSACQLAHDHTDQVIKSRRSQL 272

  Fly   259 QNGGSKEDHDPSLPRKKMAFLDTLLSSTID-GRPLTRQEIYEEVSTFMFEGHDTTTSGVSFSVYL 322
            |:   :|:.:....::::.|||.||.:.:: |:.|:.:::..||.||||||||||.||:|:..|.
Mouse   273 QD---EEELEKLKKKRRLDFLDILLFARMENGKSLSDKDLRAEVDTFMFEGHDTTASGISWIFYA 334

  Fly   323 LSRHPDVQRKLYREQCEVMGHDMNRSVSFQEIAKMKYLDLFIKEAQRVYPSVPFIGRYCDKDYDI 387
            |:.:|:.|::..:|...::|.  ..|:::.::.||.|..:.||||.|:||.||.:.|........
Mouse   335 LATNPEHQQRCRKEIQSLLGD--GASITWNDLDKMPYTTMCIKEALRIYPPVPSVSRELSSPVTF 397

  Fly   388 -NGSIVPKGTTLNLALILLGYNDRIFKDPHHFRPERFEEEKPAP------FEYLPFSAGPRNCIG 445
             :|..:|||..:.|:...|.:|..::.:|..|.|.||     ||      ..:||||.|.|||||
Mouse   398 PDGRSLPKGIHVMLSFYGLHHNPTVWPNPEVFDPSRF-----APGSSRHSHSFLPFSGGARNCIG 457

  Fly   446 QKFALLELKTVISKVVRSFEVLPAVDELVSTDGRLNTYLGLAPDEKLKREAGRHKYDPILSAVLT 510
            ::||:.|||..::..:..||:||....:                             ||....:.
Mouse   458 KQFAMNELKVAVALTLLRFELLPDPTRV-----------------------------PIPIPRIV 493

  Fly   511 LKSDNGLHLRLRE 523
            |||.||:||.|::
Mouse   494 LKSKNGIHLHLKK 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	p450	35..468	CDD:278495	125/447 (28%)
Cyp4a12b	NP_758510.2	CYP4B-like	70..503	CDD:410771	133/482 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845022
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.650