Protein Alignment Cyp4e3 and Cyp46a1

DIOPT Version :9

• Sequence 1: NP_523527.1
• Gene: Cyp4e3 / 34291
• FlyBaseID: FBgn0015035
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_034140.1
• Gene: Cyp46a1 / 13116
• MGIID: 1341877
• Length: 500
• Species: Mus musculus
• Alignment Length: 492
• Identity: 127/492 - (25%)
• Similarity: 232/492 - (47%)
• Gaps: 67/492 - (13%)

  Fly    36 PTPVPILGNANRIGKNPAE----ILSTFFDWWYDYG---KDNFLFWIGYSSHIVMTNPKQLEYIL 93
            |.|..:||:.....|...:    :...|.||...||   :.|    :.|.:.:::|:|:.::..|
Mouse    37 PRPSFLLGHLPYFWKKDEDCGRVLQDVFLDWAKKYGPVVRVN----VFYKTSVIVTSPESVKKFL 97

  Fly    94 NSQQLIQKSTIYDLLHP-----WLGHGLLT--SFGSKWHKHRKMITPSFHFNILQDFHEVMNENS 151
            .|.:..:.|.:|..|..     ..|.||::  .:| :|:|.||::..:|..:.|....|..||.:
Mouse    98 MSTKYNKDSKMYRALQTVFGERLFGQGLVSECDYG-RWYKQRKVMDLAFSRSSLVSLMETFNEKA 161

  Fly   152 AKFMTQLKKASAGDTIIDFQEHANYLTLDVICDTAMGVPINAMEQRDSSIVQAFRDMCYNIN--- 213
            .:.:..|:..:.|.|.:..|:.....|:|::...|.|:..:.:......:.||.:.|...|:
Mouse   162 EQLVEILEAKADGQTPVSMQDMLTCATIDILAKAAFGMETSMLLGAQKPLSQAVKVMLEGISASR 226

  Fly   214 --MRAFHPFKRSNRVFSLTPEFSAYQKTLKTLQDFTYDIIEKRVYALQNGGSKEDHDPSLPRKKM 276
              :..|.|.||.        :....:::::.|:....|.:::|..||:.|   ||    :|
Mouse   227 NTLAKFMPGKRK--------QLREIRESIRLLRQVGKDWVQRRREALKRG---ED----MP---- 272

  Fly   277 AFLDTLLSSTIDGRPLTRQEIYEEVSTFMFEGHDTTTSGVSFSVYLLSRHPDVQRKLYREQCEVM 341
            |.:.|.:....:|.. ..:.:.:...||...||:|:.:.::|:|..|||.|::..:|..|..||:
Mouse   273 ADILTQILKAEEGAQ-DDEVLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVV 336

  Fly   342 GHDMNRSVSFQEIAKMKYLDLFIKEAQRVYPSVPFIGRYCDKDYDINGSIVPKGTTLNLALILLG 406
            |  ..|.:.::::.:::||...:||:.|:||......|..:::..|:|..||..|.|..:..::|
Mouse   337 G--SKRHLDYEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMG 399

  Fly   407 YNDRIFKDPHHFRPERFEEEKPAP-FEYLPFSAGPRNCIGQKFALLELKTVISKVVRSFEVLPAV 470
            ..|..|:||..|.|:||....|.| |.|.|||.|.|:||||:||.:|:|.|::|:::..|
Mouse   400 RMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRIE----- 459

  Fly   471 DELVSTDGRLNTYLGLAPDEK--LKREAGRHKYDPIL 505
                         ..|.|.::  |:.:|.....||:|
Mouse   460 -------------FRLVPGQRFGLQEQATLKPLDPVL 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	p450	35..468	CDD:278495	120/451 (27%)
Cyp46a1	NP_034140.1	p450	34..466	CDD:278495	122/473 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4382
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.760