Protein Alignment Cyp4e3 and Cyp3a16

DIOPT Version :10

• Sequence 1: NP_523527.1
• Gene: Cyp4e3 / 34291
• FlyBaseID: FBgn0015035
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_031846.2
• Gene: Cyp3a16 / 13114
• MGIID: 106099
• Length: 504
• Species: Mus musculus
• Alignment Length: 541
• Identity: 142/541 - (26%)
• Similarity: 253/541 - (46%)
• Gaps: 83/541 - (15%)

  Fly     6 LALLVLPLITLVYFERKASQRRQLLKE--FNGPTPVPILGNANRIGKNPAEILSTFFDWW----- 63
            |..|||..|.||...|..:....|.|:  ..||.|:|.||.          :|:.:...|
Mouse     9 LDTLVLLAIILVLLYRYGTCTHGLFKKQGIPGPKPLPFLGT----------VLNYYKGLWKFDME 63

  Fly    64 -YD-YGKDNFLFWIGYSSHIVMTNPKQLEYILNSQQLIQKSTIYDLLHPWLGHGLLTSFGS---- 122
             |: |||...|| .|.....|:|:|:.::.:|..:..    :::.....:...|:::...|
Mouse    64 CYEKYGKTWGLF-DGQIPLFVITDPETIKNVLVKECF----SVFTNRQDFFPVGIMSKSISLAKD 123

  Fly   123 -KWHKHRKMITPSFHFNILQDFHEVMNENSAKFMTQLKKASAGDTIIDFQEHANYLTLDVICDTA 186
             :|.::|.:::|:|....|::...|:.:.....:..|::.:.....:..::.....::|||..|.
Mouse   124 EEWKRYRALLSPTFTSGNLKEMFPVIEQYGDILVKYLRQEAEKGKPVAVKDVLGAYSMDVIISTT 188

  Fly   187 MGVPINAMEQRDSSIVQAFRDMCYNINMRAFHPFKRSNRVFS-LTPEFSAY------QKTLKTLQ 244
            .||.|:::...:...|:..:.:   :....|.|...|..:|. |||.:...      :.:::..:
Mouse   189 FGVNIDSLNNPEDPFVENAKKV---LRFDYFDPLSLSVALFPFLTPIYEMLNICMFPKDSIEFFK 250

  Fly   245 DFTYDIIEKRVYALQNGGSKEDHDPSLPRKKMAFLDTLL-----SSTIDG-RPLTRQEIYEEVST 303
            .|...:.|.|:      .||:.|       ::.|:..::     |...|. :.|:..||..:...
Mouse   251 KFVDRMTENRL------DSKQKH-------RVDFIYLMMEAYNKSKDKDSHKALSEIEITAQSII 302

  Fly   304 FMFEGHDTTTSGVSFSVYLLSRHPDVQRKLYREQCEVMGHDMNRSVSFQEIAKMKYLDLFIKEAQ 368
            |:|.|::||:|.:||:||.|:.|||:|:||..|..|.:.:  ....::..:..|:|||:.:.|..
Mouse   303 FIFAGYETTSSILSFTVYSLATHPDIQKKLQEEIDEALPN--KAPPTYDTVMAMEYLDMVLNETL 365

  Fly   369 RVYPSVPFIGRYCDKDYDINGSIVPKGTTLNLALILLGYNDRIFKDPHHFRPERFEEEKPA---P 430
            |:||....:.|.|.||.:|||..:|||:|:.:...:|.::.:.:.:|..|:||||.:|...   |
Mouse   366 RLYPITNRLQRVCKKDVEINGIYIPKGSTVIIPSYVLHHDPQHWPEPEEFQPERFSKENKGSIDP 430

  Fly   431 FEYLPFSAGPRNCIGQKFALLELKTVISKVVRSFEVLPAVDELVSTDGRLNTYLGLAPDEKLKRE 495
            :.||||..|||||||.:|||:.:|..:.||:::|...|..:          |.:.|    ||.||
Mouse   431 YVYLPFGNGPRNCIGMRFALMNMKLALIKVLQNFSFQPCKE----------TQIPL----KLSRE 481

  Fly   496 AGRHKYDPIL------SAVLT 510
            .......||:      .||:|
Mouse   482 LLLQPVKPIVLKVVPRDAVIT 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	CYP4	68..519	CDD:410721	121/470 (26%)
Cyp3a16	NP_031846.2	CYP3A	67..493	CDD:410743	120/462 (26%)