DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4e3 and Cyp3a11

DIOPT Version :9

Sequence 1:	NP_523527.1	Gene:	Cyp4e3 / 34291	FlyBaseID:	FBgn0015035	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_031844.1	Gene:	Cyp3a11 / 13112	MGIID:	88609	Length:	504	Species:	Mus musculus

Alignment Length:	544	Identity:	135/544 - (24%)
Similarity:	263/544 - (48%)	Gaps:	97/544 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VLPLITLVYFERKASQRRQLLKE--FNGPTPVPILGNANRIGKNPAEILSTFFDWW-YD------ 65
            ||..|:||...|..:::.:|.|:  ..||.|:|.||.          :|:.:...| :|
Mouse    13 VLLAISLVLLYRYGTRKHELFKKQGIPGPKPLPFLGT----------VLNYYKGLWKFDMECYKK 67

  Fly    66 YGKDNFLFWIGYSSHIVMTNPKQLEYILNSQQLIQKSTIYDLLHPWLGHGLLT-----SFGSKWH 125
            |||...|| .|.:..:.:|:|:.::.:|..:..    :::.....:...|:::     |...:|.
Mouse    68 YGKTWGLF-DGQTPLLAVTDPETIKNVLVKECF----SVFTNRRDFGPVGIMSKAISISKDDEWK 127

  Fly   126 KHRKMITPSF-------HFNILQDFHEVMNENSAKFMTQLKKASAGDTIIDFQEHANYLTLDVIC 183
            ::|.:::|:|       .|.:::.:.:::    .|::.|  ||..|.. :..::.....::|||.
Mouse   128 RYRALLSPTFTSGKLKEMFPVIEQYGDIL----VKYLRQ--KAKKGKP-VTMKDVLGAYSMDVIT 185

  Fly   184 DTAMGVPINAMEQRDSSIVQAFRDMCYNINMRAFHPFKRSNRVFS-LTPEFSAY------QKTLK 241
            .|:.||.::::...:...|:..:.:   :....|.|...|..:|. |||.:...      :.:::
Mouse   186 STSFGVNVDSLNNPEDPFVEKAKKL---LRFDFFDPLLFSVVLFPFLTPVYEMLNICMFPKDSIE 247

  Fly   242 TLQDFTYDIIEKRVYALQNGGSKEDHDPSLPRKKMAFLDTLLSS------TIDGRPLTRQEIYEE 300
            ..:.|...:.|.|:      .||:.|       ::.||..:::|      .:..:.|:..||..:
Mouse   248 FFKKFVDRMKESRL------DSKQKH-------RVDFLQLMMNSHNNSKDKVSHKALSDMEITAQ 299

  Fly   301 VSTFMFEGHDTTTSGVSFSVYLLSRHPDVQRKLYREQCEVMGHDMNRSVSFQEIAKMKYLDLFIK 365
            ...|:|.|::||:|.:||:::.|:.|||:|:||..|..|.:.:  ....::..:.:|:|||:.:.
Mouse   300 SIIFIFAGYETTSSTLSFTLHSLATHPDIQKKLQDEIDEALPN--KAPPTYDTVMEMEYLDMVLN 362

  Fly   366 EAQRVYPSVPFIGRYCDKDYDINGSIVPKGTTLNLALILLGYNDRIFKDPHHFRPERFEEEKPA- 429
            |..|:||....:.|.|.||.::||..:|||:|:.:....|.::.:.:.:|..|:||||.:|...
Mouse   363 ETLRLYPIANRLERVCKKDVELNGVYIPKGSTVMIPSYALHHDPQHWSEPEEFQPERFSKENKGS 427

  Fly   430 --PFEYLPFSAGPRNCIGQKFALLELKTVISKVVRSFEVLPAVDELVSTDGRLNTYLGLAPDEKL 492
              |:.||||..|||||:|.:|||:.:|..::|::::|...|..:          |.:.|    ||
Mouse   428 IDPYVYLPFGNGPRNCLGMRFALMNMKLALTKIMQNFSFQPCKE----------TQIPL----KL 478

  Fly   493 KREAGRHKYDPIL------SAVLT 510
            .|:.......||:      .||:|
Mouse   479 SRQGLLQPEKPIVLKVVPRDAVIT 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	p450	35..468	CDD:278495	116/467 (25%)
Cyp3a11	NP_031844.1	p450	39..494	CDD:278495	124/508 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810