DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e3 and Cyp26a1

DIOPT Version :9

Sequence 1:	NP_523527.1	Gene:	Cyp4e3 / 34291	FlyBaseID:	FBgn0015035	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_031837.2	Gene:	Cyp26a1 / 13082	MGIID:	1096359	Length:	497	Species:	Mus musculus

Alignment Length:	424	Identity:	103/424 - (24%)
Similarity:	178/424 - (41%)	Gaps:	79/424 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 YSSHI-------VMTNPKQLEYILNSQQLIQKSTIYDLLHPW-------LGHGLLTSFGSKWHKH 127
            |.:|:       ||........:|...:|:.       :| |       ||.|.|::.....||.
Mouse    79 YKTHLFGRPTVRVMGADNVRRILLGEHRLVS-------VH-WPASVRTILGAGCLSNLHDSSHKQ 135

  Fly   128 R-KMITPSFHFNILQDFHEVMNENSAKFMTQLKKASAGDTIIDFQEHANYLTLDVICDTAMGV-- 189
            | |:|..:|....||.:..|:.|..:..:.|.  .|.|:..:........|...:.....:|.
Mouse   136 RKKVIMQAFSREALQCYVPVIAEEVSSCLEQW--LSCGERGLLVYPEVKRLMFRIAMRILLGCEP 198

  Fly   190 -PINAMEQRDSSIVQAFRDMCYNINMRAFHPFKRSNRVFSLTPE--FSAYQKTLKTLQDFTYDII 251
             |....|. :..:|:||.:|..|:              |||..:  ||...:.:|. ::..:..|
Mouse   199 GPAGGGED-EQQLVEAFEEMTRNL--------------FSLPIDVPFSGLYRGVKA-RNLIHARI 247

  Fly   252 EKRVYA----LQ----NGGSKEDHDPSLPRKKMAFLDTLLSSTID-GRPLTRQEIYEEVSTFMFE 307
            |:.:.|    ||    :||.|:            .|..|:..:.: |..|..|.:.:..:..:|.
Mouse   248 EENIRAKIRRLQATEPDGGCKD------------ALQLLIEHSWERGERLDMQALKQSSTELLFG 300

  Fly   308 GHDTTTSGVSFSVYLLSRHPDVQRKLYREQCEVMG----HDMNRSVSFQEIAKMKYLDLFIKEAQ 368
            ||:||.|..:..:..|..:|.|.:|: ||:.:..|    .:.:..:..:.:.::||....|||..
Mouse   301 GHETTASAATSLITYLGLYPHVLQKV-REEIKSKGLLCKSNQDNKLDMETLEQLKYTGCVIKETL 364

  Fly   369 RVYPSVPFIGRYCDKDYDINGSIVPKGTTLNLALILLGYND--RIFKDPHHFRPERF---EEEKP 428
            |:.|.||...|...|.:::||..:|||  .|:...:...:|  .||.:...|.|:||   ..|..
Mouse   365 RLNPPVPGGFRVALKTFELNGYQIPKG--WNVIYSICDTHDVADIFTNKEEFNPDRFIVPHPEDA 427

  Fly   429 APFEYLPFSAGPRNCIGQKFALLELKTVISKVVR 462
            :.|.::||..|.|:|:|::||.:.||....::.|
Mouse   428 SRFSFIPFGGGLRSCVGKEFAKILLKIFTVELAR 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	p450	35..468	CDD:278495	103/424 (24%)
Cyp26a1	NP_031837.2	p450	43..491	CDD:299894	103/424 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910