Protein Alignment Cyp4e3 and Cyp24a1

DIOPT Version :10

• Sequence 1: NP_523527.1
• Gene: Cyp4e3 / 34291
• FlyBaseID: FBgn0015035
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_034126.1
• Gene: Cyp24a1 / 13081
• MGIID: 88593
• Length: 514
• Species: Mus musculus
• Alignment Length: 503
• Identity: 123/503 - (24%)
• Similarity: 211/503 - (41%)
• Gaps: 100/503 - (19%)

  Fly    35 GPTPVPILGNANRIGKNPAEIL---------STFFDWWYDYGKDNFLFWIGYSSHIVMTNPKQLE 90
            |||..|:||:.       .||.         .|..::...||: .|...:|....:.:.:|..||
Mouse    60 GPTNWPLLGSL-------LEIFWKGGLKKQHDTLAEYHKKYGQ-IFRMKLGSFDSVHLGSPSLLE 116

  Fly    91 YILNSQ----QLIQKSTIYDLLHPWL--------GHGLLTSFGSKWHK-----HRKMITPSFHFN 138
            .:..::    |.::       :.||.        .:||:...|.:|.:     .:|::.|.....
Mouse   117 ALYRTESAHPQRLE-------IKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMK 174

  Fly   139 ILQDFHEVMNENSAKFMTQLKK-ASAGDTIIDFQEHANYLTLDVIC----DTAMGVPINAMEQRD 198
            :.:..:||:    |.||.|:.: ......|.|.....|..:.:.||    :...|:.....|:..
Mouse   175 LDKKINEVL----ADFMGQIDELRDERGRIQDLYSELNKWSFESICLVLYEKRFGLLQKDTEEEA 235

  Fly   199 SSIVQAFRDMCYNINMRAFHP---FKRSNRVFSLTPEFSAYQKTLKTLQDFTYDIIEKRV--YAL 258
            .:.:.|.:.|..........|   .||.|     |..:.|:.....|:.......|:.|:  |:.
Mouse   236 LTFIAAIKTMMSTFGKMMVTPVELHKRLN-----TKVWQAHTLAWDTIFKSVKPCIDHRLERYSQ 295

  Fly   259 QNGGS------KEDHDPSLPRKKMAFLDTLLSSTIDGRPLTRQEIYEEVSTFMFEGHDTTTSGVS 317
            |.|..      ::||                        |:::|:|..|:.......:||.:.:.
Mouse   296 QPGADFLCDIYQQDH------------------------LSKKELYAAVTELQLAAVETTANSLM 336

  Fly   318 FSVYLLSRHPDVQRKLYREQCEVMGHDMNRSVSFQEIAKMKYLDLFIKEAQRVYPSVPFIGRYCD 382
            :.:|.|||:|.||::|.||...|:..  |::...:::..|.||...:||:.|:.|||||..|..|
Mouse   337 WILYNLSRNPQVQQRLLREIQSVLPD--NQTPRAEDVRNMPYLKACLKESMRLTPSVPFTTRTLD 399

  Fly   383 KDYDINGSIVPKGTTLNLALILLGYNDRIFKDPHHFRPERF--EEEKPAPFEYLPFSAGPRNCIG 445
            |...:....:||||.|.|...:||.::..|:|...|||||:  :|:|..||.:|||..|.|.|||
Mouse   400 KPTVLGEYTLPKGTVLTLNTQVLGSSEDNFEDADKFRPERWLEKEKKINPFAHLPFGVGKRMCIG 464

  Fly   446 QKFALLELKTVISKVVRSFEVLPAVDELVSTDGRLNTYLG-LAPDEKL 492
            ::.|.|:|...:..:::.:.::....|.|..     .:|| |.|..:|
Mouse   465 RRLAELQLHLALCWIIQKYNIVATDSEPVEM-----LHLGILVPSREL 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	CYP4	68..519	CDD:410721	112/461 (24%)
Cyp24a1	NP_034126.1	CYP24A1	90..508	CDD:410738	114/466 (24%)