DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4e3 and Cyp19a1

DIOPT Version :9

Sequence 1:	NP_523527.1	Gene:	Cyp4e3 / 34291	FlyBaseID:	FBgn0015035	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001335100.1	Gene:	Cyp19a1 / 13075	MGIID:	88587	Length:	503	Species:	Mus musculus

Alignment Length:	545	Identity:	123/545 - (22%)
Similarity:	233/545 - (42%)	Gaps:	118/545 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 AVLALLVLPLITLVYFERKASQRRQLLKEFNGPTPVPILGNANRIGKNPAEILSTFFDWWYDYGK 68
            |:..||::.|:.|::               |..:...|.|....:|..|  ::|        :|:
Mouse    25 AMPLLLIMGLLLLIW---------------NCESSSSIPGPGYCLGIGP--LIS--------HGR 64

  Fly    69 DNFLFWIGYSSHIVMTNPKQLEYI---LNSQQ--LIQKSTIYDLLHPWLGHGLLTSFGSKWHKHR 128
              || |:|..|.....|....|::   ::.::  :|.||:  .:.|.......::.||||    |
Mouse    65 --FL-WMGIGSACNYYNKMYGEFMRVWISGEETLIISKSS--SMFHVMKHSHYISRFGSK----R 120

  Fly   129 KMITPSFHFNILQDFHEVMNENSAKFMT---QLKKASAGDTII---------------------D 169
            .:.....|.|.:     :.|.|.:.:.|   ...||..|..::                     |
Mouse   121 GLQCIGMHENGI-----IFNNNPSLWRTIRPFFMKALTGPGLVRMVEVCVESIKQHLDRLGEVTD 180

  Fly   170 FQEHANYLTL--DVICDTA----MGVPINAMEQRDSSIVQAFRDMCYNINMRAFHPFK----RSN 224
            ...:.:.|||  .::.||:    :|:|::     :|:||:..:..        |:.::    :.|
Mouse   181 TSGYVDVLTLMRHIMLDTSNMLFLGIPLD-----ESAIVKKIQGY--------FNAWQALLIKPN 232

  Fly   225 RVFSLTPEFSAYQKTLKTLQDFTYDIIEKRVYALQNGGSKEDHDPSLPRKKMAFLDTLLSSTIDG 289
            ..|.::..:..|::::|.|:|....::||:.:.:......||        .|.|...|:.:...|
Mouse   233 IFFKISWLYRKYERSVKDLKDEIAVLVEKKRHKVSTAEKLED--------CMDFATDLIFAERRG 289

  Fly   290 RPLTRQEIYEEVSTFMFEGHDTTTSGVSFSVYLLSRHPDVQRKLYREQCEVMGHDMNRSVSFQEI 354
             .||::.:.:.:...:....||.:..:.|.:.|::.:|:|:..:.:|...|:|   :|.:..::|
Mouse   290 -DLTKENVNQCILEMLIAAPDTMSVTLYFMLLLVAEYPEVEAAILKEIHTVVG---DRDIKIEDI 350

  Fly   355 AKMKYLDLFIKEAQRVYPSVPFIGRYCDKDYDINGSIVPKGTTLNLALILLGYNDRI--FKDPHH 417
            ..:|.::.||.|:.|..|.|..:.|...:|..|:|..|.|||.:   ::.:|...|:  |..|:.
Mouse   351 QNLKVVENFINESMRYQPVVDLVMRRALEDDVIDGYPVKKGTNI---ILNIGRMHRLEYFPKPNE 412

  Fly   418 FRPERFEEEKPAPFEYL-PFSAGPRNCIGQKFALLELKTVISKVVRSFEVLPAVDELVSTDGRLN 481
            |..|.|  ||..|:.|. ||..|||.|.|:..|::.:|.|:..::|.|:|.......:....:.|
Mouse   413 FTLENF--EKNVPYRYFQPFGFGPRGCAGKYIAMVMMKVVLVTLLRRFQVKTLQKRCIENIPKKN 475

  Fly   482 TYLGLAPDEKLKREAGRHKYDPILS 506
            . |.|.|:|      .||..:.|.|
Mouse   476 D-LSLHPNE------DRHLVEIIFS 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	p450	35..468	CDD:278495	108/474 (23%)
Cyp19a1	NP_001335100.1	p450	48..488	CDD:306555	114/500 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845262
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.950