Protein Alignment Cyp4e3 and CYP4F22

DIOPT Version :10

• Sequence 1: NP_523527.1
• Gene: Cyp4e3 / 34291
• FlyBaseID: FBgn0015035
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_775754.2
• Gene: CYP4F22 / 126410
• HGNCID: 26820
• Length: 531
• Species: Homo sapiens
• Alignment Length: 467
• Identity: 135/467 - (28%)
• Similarity: 244/467 - (52%)
• Gaps: 46/467 - (9%)

  Fly    69 DN----FLFWIG-YSSHIVMTNPKQLEYILNSQQLI--QKSTIYDLLHPWLGHGLLTSFGSKWHK 126
            ||    .|.|:| ....:|:.:|..::.:|.:...|  :....|..|.||||.|||.|.|.||.:
Human    90 DNMHHVLLVWMGPVLPLLVLVHPDYIKPLLGASAAIAPKDDLFYGFLKPWLGDGLLLSKGDKWSR 154

  Fly   127 HRKMITPSFHFNILQDFHEVMNENSAKFMTQLKKASAGDTI-IDFQEHANYLTLDVICDTAMGVP 190
            ||:::||:|||:||:.:.::.|:::.....:.:..:.|..: :|..||.:.:|||.:........
Human   155 HRRLLTPAFHFDILKPYMKIFNQSADIMHAKWRHLAEGSAVSLDMFEHISLMTLDSLQKCVFSYN 219

  Fly   191 INAMEQRDSSIVQAFRDMCYNINMRAFHPFKRSNRVFSLTPEFSAYQKTLKTLQDFTYDIIEKRV 255
            .|..|:. |..:.|..::......|.:......:.::..:.:...:::....:..||.::|::|.
Human   220 SNCQEKM-SDYISAIIELSALSVRRQYRLHHYLDFIYYRSADGRRFRQACDMVHHFTTEVIQERR 283

  Fly   256 YALQNGGSKEDHDPSLPRKKMAFLDT-LLSSTIDGRPLTRQEIYEEVSTFMFEGHDTTTSGVSFS 319
            .||:..|: |....:...|.:.|:|. ||:...||:.|:.::|..|..||||||||||:||:|:.
Human   284 RALRQQGA-EAWLKAKQGKTLDFIDVLLLARDEDGKELSDEDIRAEADTFMFEGHDTTSSGISWM 347

  Fly   320 VYLLSRHPDVQRKLYREQCEVM-GHDMNRSVSFQEIAKMKYLDLFIKEAQRVYPSVPFIGRYCDK 383
            ::.|:::|:.|.|...|..||| |.:: ..:.:.::.::.:..:.|||:.|.||.|..:.|.|.:
Human   348 LFNLAKYPEYQEKCREEIQEVMKGREL-EELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTE 411

  Fly   384 DYDI-NGSIVPKGTTLNLALILLGYNDRIFKDPHHFRPERFEEEKP---APFEYLPFSAGPRNCI 444
            |..: :|.|:|||....:::....:|..::.|...:.|.||:.:.|   :|..|:||||||||||
Human   412 DIKLPDGRIIPKGIICLVSIYGTHHNPTVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCI 476

  Fly   445 GQKFALLELKTVISKVVRSFEVLPAVDELVSTDGRLNTYLGLAPDEKLKREAGRHKYDPILSAVL 509
            ||.||:.||:.|::..:..|.:  :||.                ..|::|:           ..|
Human   477 GQSFAMAELRVVVALTLLRFRL--SVDR----------------TRKVRRK-----------PEL 512

  Fly   510 TLKSDNGLHLRL 521
            .|:::|||.|::
Human   513 ILRTENGLWLKV 524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	CYP4	68..519	CDD:410721	134/463 (29%)
CYP4F22	NP_775754.2	CYP4F	82..523	CDD:410772	134/464 (29%)