Protein Alignment Cyp4e3 and CYP4F8

DIOPT Version :9

• Sequence 1: NP_523527.1
• Gene: Cyp4e3 / 34291
• FlyBaseID: FBgn0015035
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_009184.1
• Gene: CYP4F8 / 11283
• HGNCID: 2648
• Length: 520
• Species: Homo sapiens
• Alignment Length: 463
• Identity: 141/463 - (30%)
• Similarity: 246/463 - (53%)
• Gaps: 46/463 - (9%)

  Fly    71 FLFWIGYSSHIV-MTNPKQLEYILNSQQLIQKSTI--YDLLHPWLGHGLLTSFGSKWHKHRKMIT 132
            |:.|:|..:.|: :.:|..:..::|:...|....|  |..|.||||.|||.|.|.||..||:::|
Human    88 FVRWLGPITPIINLCHPDIVRSVINTSDAITDKDIVFYKTLKPWLGDGLLLSVGDKWRHHRRLLT 152

  Fly   133 PSFHFNILQDFHEVMNENS----AKFMTQLKKASAGDTIIDFQEHANYLTLDVICDTAMGVPINA 193
            |:||||||:.:.::.::::    ||:.   :.|..|.|.:|..||.:.:|||.:.........|.
Human   153 PAFHFNILKPYIKIFSKSANIMHAKWQ---RLAMEGSTCLDVFEHISLMTLDSLQKCIFSFDSNC 214

  Fly   194 MEQRDSSIVQAFRDMCYNINMRAFHPFKRSNRVFSLTPEFSAYQKTLKTLQDFTYDIIEKRVYAL 258
            .| :.|..:.|..::...:..|....|:..:.::.|||....:.:..:.:.|||..:|::|...|
Human   215 QE-KPSEYITAIMELSALVVKRNNQFFRYKDFLYFLTPCGRRFHRACRLVHDFTDAVIQERRRTL 278

  Fly   259 QNGGSKEDHDPSLPRKKMAFLDT-LLSSTIDGRPLTRQEIYEEVSTFMFEGHDTTTSGVSFSVYL 322
            .:.|..:........|.:.|:|. |||...:|:.|:.::|..|..||||.|||||.||:|:.:|.
Human   279 TSQGVDDFLQAKAKSKTLDFIDVLLLSEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYN 343

  Fly   323 LSRHPDVQRKLYREQCEVMGHDMNRSVSFQEIAKMKYLDLFIKEAQRVYPSVPFIGRYCDKDYDI 387
            |:|||:.|.:..:|..|::.....:.:.:.::|::.:|.:.:||:.|::|.:|...|.|.:|..:
Human   344 LARHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVL 408

  Fly   388 NGS-IVPKGTTLNLALILLGYNDRIFKDPHHFRPERFEEE---KPAPFEYLPFSAGPRNCIGQKF 448
            ..| ::|||...|:.:..:.:|..::.||..:.|.||:.|   |.:|..::||||||||||||||
Human   409 PDSRVIPKGNVCNINIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQKF 473

  Fly   449 ALLELKTVISKVVRSFEVLPAVDELVSTDGRLNTYLGLAPDEKLKREAGRHKYDPILSAVLTLKS 513
            |:.|:|.|::..:..|.:||        |.|                      :|..:..:.|::
Human   474 AMAEMKVVLALTLLRFRILP--------DHR----------------------EPRRTPEIVLRA 508

  Fly   514 DNGLHLRL 521
            ::||.||:
Human   509 EDGLWLRV 516

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	p450	35..468	CDD:278495	131/408 (32%)
CYP4F8	NP_009184.1	p450	52..504	CDD:306555	136/449 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154725
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.650