Protein Alignment Cyp4e3 and CYP46A1

DIOPT Version :10

• Sequence 1: NP_523527.1
• Gene: Cyp4e3 / 34291
• FlyBaseID: FBgn0015035
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_006659.1
• Gene: CYP46A1 / 10858
• HGNCID: 2641
• Length: 500
• Species: Homo sapiens
• Alignment Length: 509
• Identity: 125/509 - (24%)
• Similarity: 225/509 - (44%)
• Gaps: 101/509 - (19%)

  Fly    36 PTPVPILGN------ANRIGKNPAEILSTFFDWWYDYG---KDNFLFWIGYSSHIVMTNPKQLEY 91
            |.|..:||:      .:.:|....:  ..|.||...||   :.|    :.:.:.:::|:|:.::.
Human    37 PRPSFLLGHLPCFWKKDEVGGRVLQ--DVFLDWAKKYGPVVRVN----VFHKTSVIVTSPESVKK 95

  Fly    92 ILNSQQLIQKSTIYDLLHP-----WLGHGLLTSFG-SKWHKHRKMITPSFHFNILQDFHEVMNEN 150
            .|.|.:..:.|.:|..|..     ..|.||::... .:|||.|::|..:|..:.|....|..||.
Human    96 FLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEK 160

  Fly   151 SAKFMTQLKKASAGDTIIDFQEHANYLTLDVICDTAMGVPINAMEQRDSSIVQAFRDMCYNI--- 212
            :.:.:..|:..:.|.|.:..|:...|..:|::...|.|:..:.:......:.||.:.|...|
Human   161 AEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITAS 225

  Fly   213 --NMRAFHPFKRSNRVFSLTPEFSAYQKTLKTLQDFTYDIIEKRVYALQNG-------------- 261
              .:..|.|.||.        :....:::::.|:....|.:::|..||:.|
Human   226 RNTLAKFLPGKRK--------QLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKA 282

  Fly   262 --GSKEDHDPSLPRKKMAFLDTLLSSTIDGRPLTRQEIYEEVSTFMFEGHDTTTSGVSFSVYLLS 324
              |:::|.         ..||..:                   ||...||:|:.:.::|:|..||
Human   283 EEGAQDDE---------GLLDNFV-------------------TFFIAGHETSANHLAFTVMELS 319

  Fly   325 RHPDVQRKLYREQCEVMGHDMNRSVSFQEIAKMKYLDLFIKEAQRVYPSVPFIGRYCDKDYDING 389
            |.|::..:|..|..||:|  ..|.:.|:::.:::||...:||:.|:||......|..:::..|:|
Human   320 RQPEIVARLQAEVDEVIG--SKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDG 382

  Fly   390 SIVPKGTTLNLALILLGYNDRIFKDPHHFRPERFEEEKPAP-FEYLPFSAGPRNCIGQKFALLEL 453
            ..||..|.|..:..::|..|..|:||..|.|:||....|.| |.|.|||.|.|:||||:||.:|:
Human   383 VRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEV 447

  Fly   454 KTVISKVVRSFEVLPAVDELVSTDGRLNTYLGLAPDEK--LKREAGRHKYDPIL 505
            |.|::|:::..|                  ..|.|.::  |:.:|.....||:|
Human   448 KVVMAKLLQRLE------------------FRLVPGQRFGLQEQATLKPLDPVL 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	CYP4	68..519	CDD:410721	115/468 (25%)
CYP46A1	NP_006659.1	CYP46A1-like	61..484	CDD:410706	120/485 (25%)