Protein Alignment Cyp4e3 and cyp46a1.4

DIOPT Version :10

• Sequence 1: NP_523527.1
• Gene: Cyp4e3 / 34291
• FlyBaseID: FBgn0015035
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: XP_002933245.2
• Gene: cyp46a1.4 / 100498621
• XenbaseID: XB-GENE-29072485
• Length: 504
• Species: Xenopus tropicalis
• Alignment Length: 555
• Identity: 145/555 - (26%)
• Similarity: 237/555 - (42%)
• Gaps: 95/555 - (17%)

  Fly     1 MWLAVLA----------LLVLPLITLVYFERKASQRRQLLKEFNGPTP---------VPILGNAN 46
            ||.:|:.          ||::....:.:....|..:...||..:.|.|         :|.|..|.
 Frog     1 MWHSVIVHCLSWVYSGFLLIIIGAVVAFLAYCAYIKYMHLKYDDIPGPPRDSFLLGHIPTLSKAE 65

  Fly    47 RIGKNPAEILSTFFDWWYDYG---KDNFLFWIGYSSHIVM---TNPKQLEYILNSQQLIQKSTIY 105
               :|.:.:...|..|...||   |.|.|       |.||   |:|:.::..|.|.:..:....|
 Frog    66 ---ENYSVVHDLFLHWAEIYGPVFKINIL-------HRVMIYSTSPESVKECLMSSKYPKDPYTY 120

  Fly   106 DLL-----HPWLGHGLLTS-FGSKWHKHRKMITPSFHFNILQDFHEVMNENSAKFMTQLKKASAG 164
            :.|     ..:||.||||. ....|:..|:::.|:|....|::...:.||.:.:.|.:|::.:.|
 Frog   121 NQLFNLFGKRFLGKGLLTDPDHDHWYHQRRIMDPAFSNTYLKEMIGIFNERAEQMMEKLEEKADG 185

  Fly   165 DTIIDFQEHANYLTLDVICDTAMGVPINAMEQRDSSIVQAFRDMCYNINMRAFHPFKRSNRVFSL 229
            ...:......|.:|||||...|.|:.:..:|...:....|...:...:.....:|:      ...
 Frog   186 HQEVSMHSIINRVTLDVITKVAFGMDLGLVEGNKTDFPNAISKVLTGMMRYMQNPY------MQY 244

  Fly   230 TPEFSAY----QKTLKTLQDFTYDIIEKRVYALQNGGSKEDHDPSLPRK------KMAFLDTLLS 284
            .|:..|:    |::...|:....:.|.:|..|:|||       ..||:.      :.|.|:..|.
 Frog   245 FPKHWAFVREVQESADLLRKTGKECISQRKKAMQNG-------EELPKDILTKILQCAELENALD 302

  Fly   285 STIDGRPLTRQEIYEEVSTFMFEGHDTTTSGVSFSVYLLSRHPDVQRKLYREQCEVMGHDMNRSV 349
            ..|         :.:...||...|.:||.:.:||:|..|:|.|::..||..|..||:|  ..|.:
 Frog   303 DEI---------MLDNFITFFIAGQETTANQLSFTVMELTRQPEIMTKLRMEVDEVIG--FKRDI 356

  Fly   350 SFQEIAKMKYLDLFIKEAQRVYPSVPFIGRYCDKDYDINGSIVPKGTTLNLALILLGYNDRIFKD 414
            |:.:|..:.|:...:||:.|.||..|...||..:|....|..:|.|.::.....::|..::.|:|
 Frog   357 SYDDIQNLNYMTQVLKESLRFYPPGPGTSRYLKEDTIFEGIKIPGGVSITFNTYVMGRMEKFFQD 421

  Fly   415 PHHFRPERFEEEKPAP-FEYLPFSAGPRNCIGQKFALLELKTVISKVVRSFEVLPAVDELVSTDG 478
            |..|.||||......| |.|.||:.|||:|:||.|:.||.|.::||:::.||.     |||....
 Frog   422 PCKFDPERFHPAAVKPYFCYFPFALGPRSCLGQIFSQLEAKVILSKLIQRFEF-----ELVPGQS 481

  Fly   479 RLNTYLGLAPDEKLKREAGRHKYDPILSAVLTLKS 513
                 .|:.....|:...|         .|.||||
 Frog   482 -----FGIKDTGTLRPRDG---------VVCTLKS 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	CYP4	68..519	CDD:410721	127/466 (27%)
cyp46a1.4	XP_002933245.2	CYP46A1-like	72..498	CDD:410706	126/475 (27%)