DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e3 and Cyp2c69

DIOPT Version :9

Sequence 1:	NP_523527.1	Gene:	Cyp4e3 / 34291	FlyBaseID:	FBgn0015035	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001097995.1	Gene:	Cyp2c69 / 100043108	MGIID:	3721049	Length:	491	Species:	Mus musculus

Alignment Length:	522	Identity:	121/522 - (23%)
Similarity:	212/522 - (40%)	Gaps:	118/522 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 VLALLVLPLITLVYFERKASQRRQLLKEFNGPTPVPILGNANRIG-KNPAEILSTFFDWWYDYGK 68
            |:.:|.|..:.|:...|:.|.||.|..   ||||:||:||.:.|. |:..:.|:.|..   .||.
Mouse     5 VVLVLCLSFMLLLSLWRQRSARRNLPP---GPTPLPIIGNYHLIDMKDIGQCLTNFSK---TYGP 63

  Fly    69 DNFLFWIGYSSHIVMTNPKQLEYILNSQQLIQKSTI--------------YDLLHPWLGHGLLTS 119
               :|.:.:.|..::        :|:..:.|:::.|              :|.:..  |.|:..|
Mouse    64 ---VFTLYFGSQPIV--------VLHGYEAIKEALIDHGEVFSGRGSFPFFDKVSK--GKGIGFS 115

  Fly   120 FGSKWHKHRKMITPSFHFNILQDFHEVMN---ENSAKFMTQLKKASAGD---------------T 166
            .|:.| |..::.|.:...|:......:.|   |.:...|.:|||.:...               .
Mouse   116 HGNVW-KATRVFTVNTLRNLAMGKRTIENKVQEEAQWLMKELKKTNGSPCDPQFIIGCAPCNVIC 179

  Fly   167 IIDFQEHANYLTLDVICDTAMGVPINAMEQRDSSIVQAFR------DMCYNINMRAFHPFKRSNR 225
            .|.||...:|...|.:  :.:|......|...|...|.|.      |.|..          |.|:
Mouse   180 SIVFQNRFDYKDKDFL--SLIGKVNECTEILSSPGCQIFNAVPILIDYCPG----------RHNK 232

  Fly   226 VFSLTPEFSAYQKTLKTLQDFTYDIIEKRVYALQNGGSKEDHDPSL----PRKKMAFLDTLL--- 283
            .|.......:|             ::||          .::|:.||    ||.   |:|..|
Mouse   233 FFKNHTWIKSY-------------LLEK----------IKEHEESLDVTNPRD---FIDYFLIQR 271

  Fly   284 --SSTIDGRPLTRQEIYEEVSTFMFEGHDTTTSGVSFSVYLLSRHPDVQRKLYREQCEVMGHDMN 346
              ...|:....|.:.:...|:..:|.|.:|.:|.:.|::.||.:|..:..|:..|...|:|.  :
Mouse   272 RQDKGIEHMEYTIEHLATLVTDLVFGGTETLSSTMRFALLLLMKHTHITAKVQEEIDNVIGR--H 334

  Fly   347 RSVSFQEIAKMKYLDLFIKEAQR---VYPSVPFIGRYCDKDYDINGSIVPKGTTLNLALILLGYN 408
            ||...|:...|.|.:..:.|.||   :.|:.......||..:  ....:||||.:..:|..:.::
Mouse   335 RSPCMQDRKHMPYTNAMVHEVQRYVDLGPTSLVHEVTCDTKF--RNYFIPKGTQVMTSLSSVLHD 397

  Fly   409 DRIFKDPHHFRPERFEEE----KPAPFEYLPFSAGPRNCIGQKFALLELKTVISKVVRSFEVLPA 469
            ...|.:|..|.|..|.::    |.:.: ::|||||.|.|:|:..|.:||...::.::::|::.|.
Mouse   398 STEFPNPEVFDPGHFLDDNGNFKKSDY-FVPFSAGKRICVGESLARMELFLFLTTILQNFKLKPL 461

  Fly   470 VD 471
            ||
Mouse   462 VD 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	p450	35..468	CDD:278495	109/487 (22%)
Cyp2c69	NP_001097995.1	p450	30..487	CDD:278495	112/497 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010