DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e3 and Cyp3a59

DIOPT Version :9

Sequence 1:	NP_523527.1	Gene:	Cyp4e3 / 34291	FlyBaseID:	FBgn0015035	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001098630.1	Gene:	Cyp3a59 / 100041449	MGIID:	3769707	Length:	503	Species:	Mus musculus

Alignment Length:	535	Identity:	134/535 - (25%)
Similarity:	247/535 - (46%)	Gaps:	86/535 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VLPLITLVYFERKASQRRQLLKEFN--GPTPVPILGNANRIGKNPAEILSTFFD--WWYD----- 65
            ||.:.:||:|....:....|.|:..  ||.|:|:.|.           :..:||  |.:|
Mouse    13 VLLVTSLVFFYIYGTYSHGLFKKLGIPGPKPLPLFGT-----------IFNYFDGMWKFDEDCYK 66

  Fly    66 -YGKDNFLFWIGYSSHIVMTNPKQLEYILNSQQLIQKSTIYDLL--HPWLG------HGLLTSFG 121
             ||| .:.|::|....:.:.:|:.::.:|..:       .|.:.  .|.||      ..:..|..
Mouse    67 KYGK-IWGFYVGPKPILAIMDPEIIKIVLVKE-------CYSVFTNRPTLGPVGFLKKSITISED 123

  Fly   122 SKWHKHRKMITPSFHFNILQDFHEVMNENSAKFMTQLKKASAGDTIIDFQEHANYLTLDVICDTA 186
            .:|.:.|.:::|:|....|::...:|.:.....:..|::.......|:.::.....::|||..|:
Mouse   124 EEWKRLRTLLSPTFTSGKLKEMFPIMRQYGDILVRNLRREEEKGEPINMKDIFGAYSMDVITGTS 188

  Fly   187 MGVPINAMEQRDSSIVQAFRDMCYNINMRAFHPFKRSNRVFS-LTPEFSAYQKTLKTLQDFTYDI 250
            .||.|:::....:..||..:.:   :..:.|.||..|..:|. |||.:.     :..|..|..|.
Mouse   189 FGVNIDSLNNPQNPFVQKTKKI---LKFKIFDPFLLSTILFPFLTPIYE-----MLNLSIFPRDS 245

  Fly   251 IE------KRVYALQNGGSKEDHDPSLPRKKMAFLDTLLSS-----TIDGRPLTRQEIYEEVSTF 304
            :.      ||:        |::...|..:.::.||..::::     ....:.|:..|:..:...|
Mouse   246 MNFFKKFVKRM--------KKERLASKQKNRVDFLQLMMNTQNSKGQESQKALSDLEMAAQAVIF 302

  Fly   305 MFEGHDTTTSGVSFSVYLLSRHPDVQRKLYREQCEVMGHDMNRS-VSFQEIAKMKYLDLFIKEAQ 368
            :|.|:|.|::.:|..:|.|:.|||||:||   |.|:.....|:: |::..:..|:|||:.:.|:.
Mouse   303 IFGGYDATSTSISLIMYELATHPDVQKKL---QDEIDRTLPNKAPVTYDALMDMEYLDMVVNESL 364

  Fly   369 RVYPSVPFIGRYCDKDYDINGSIVPKGTTLNLALILLGYNDRIFKDPHHFRPERFEEEKPA---P 430
            |:||:...:.|...||.:|||..:||||.:.:.:..|..|...:.:|..|.|.||.:|...   |
Mouse   365 RLYPTAIRLERVSKKDVEINGVFIPKGTVVMIPIYPLHRNPEYWPEPQEFCPGRFSKENEGNIDP 429

  Fly   431 FEYLPFSAGPRNCIGQKFALLELKTVISKVVRSFEVLPAVDELVSTDGRLNTYLGLAPDEKLKRE 495
            :.|:||..|||||:..:|||:.:|..:..|:::|.|.|..:          |.:.|    |:.||
Mouse   430 YIYMPFGNGPRNCLDMRFALISMKLAVIGVLQNFTVQPCEE----------TQIPL----KISRE 480

  Fly   496 AGRHKYDPILSAVLT 510
            .......||:..|::
Mouse   481 PVFQPEKPIILKVVS 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	p450	35..468	CDD:278495	118/464 (25%)
Cyp3a59	NP_001098630.1	p450	39..493	CDD:278495	126/505 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810