DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e3 and Cyp4a32

DIOPT Version :9

Sequence 1:	NP_523527.1	Gene:	Cyp4e3 / 34291	FlyBaseID:	FBgn0015035	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001093651.1	Gene:	Cyp4a32 / 100040843	MGIID:	3717148	Length:	509	Species:	Mus musculus

Alignment Length:	534	Identity:	151/534 - (28%)
Similarity:	269/534 - (50%)	Gaps:	63/534 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 AVLALLVLPLITLVYFERKASQRRQLLKEFNGPTPVPILGNANRIGKNP-AEILS------TFFD 61
            :||.||:| |:..|.|........:.|::|..|......|:....|:.. .|::|      :.|.
Mouse    23 SVLGLLLL-LVKAVQFYLHRKWLLKALQQFPSPPFHWFFGHEQFKGEQELKEVVSCIEHFPSAFP 86

  Fly    62 WWYDYGKDNFLFWIGYSSHIVMTNPKQLEYILNSQQLIQKSTIYDLLHPWLGHGLLTSFGSKWHK 126
            .|         || |.::::.:.:|..::.||.... .:.:.||.||.||:|:|||...|..|.:
Mouse    87 CW---------FW-GSNAYLTVYDPDYMKVILGRSD-PKANGIYRLLAPWIGYGLLLLNGQPWFQ 140

  Fly   127 HRKMITPSFHFNILQDFHEVMNENSAKFMTQLKKASAGDTIIDFQEHANYLTLDVICDTAM---- 187
            ||:|:||:||::||:.:.:.|.::....:.:.::.:..|:.|:..:|.:.:|||.:...|.
Mouse   141 HRRMLTPAFHYDILKPYVKNMADSIRLMLDKWERLAGQDSSIEIFQHISLMTLDTVMKCAFSHKG 205

  Fly   188 GVPINAMEQRDSSIVQAFRDMCYNINMRAFHPFKRSNRVFSLTPEFSAYQKTLKTLQDFTYDIIE 252
            .|.::.   ...:.:||..|:....:.|..:.|.:::.::.|:......::..:...|.|..:|:
Mouse   206 SVQVDG---NYKTYLQAIGDLNNLFHSRVRNIFHQNDTIYRLSSNGRLAKQACQLAHDHTDGVIK 267

  Fly   253 KRVYALQNGGSKEDHDPSLPRKKMAFLDTLLSSTID-GRPLTRQEIYEEVSTFMFEGHDTTTSGV 316
            .|...||:.|..|:   ...::::.|||.||.:.:: |..::.:::..||.||||||||||.|||
Mouse   268 MRKDQLQDEGELEN---IKKKRRLDFLDILLFARMENGDSMSDKDLRAEVDTFMFEGHDTTASGV 329

  Fly   317 SFSVYLLSRHPDVQRKLYREQCEVMGHDMNRSVSFQEIAKMKYLDLFIKEAQRVYPSVPFIGRYC 381
            |:..|.|:.||:.|::...|...::|.  ..|:::..:.::.|..:.||||.|:||.||.|.|..
Mouse   330 SWIFYALATHPEHQQRCREEVQSLLGD--GSSITWDHLDQIPYTTMCIKEALRLYPPVPGIVREL 392

  Fly   382 DKDYDI-NGSIVPKGTTLNLALILLGYNDRIFKDPHHFRPERFEEEKPA-PFEYLPFSAGPRNCI 444
            ...... :|..:|||..:.|::..|.:|.:::.:|..|.|.||..:.|. ...:||||.|.||||
Mouse   393 STSVTFPDGRSLPKGVQVTLSIYGLHHNPKVWPNPEVFDPSRFAPDSPRHSHSFLPFSGGARNCI 457

  Fly   445 GQKFALLELKTVISKVVRSFEVLPAVDELVSTDGRLNTYLGLAPDEKLKREAGRHKYDPILSAVL 509
            |::||:.|||.:::..:..||:||....:               .|.|.|              :
Mouse   458 GKQFAMSELKVIVALTLLHFELLPDPTRV---------------PEPLAR--------------I 493

  Fly   510 TLKSDNGLHLRLRE 523
            .|||.||::|.|::
Mouse   494 VLKSKNGIYLHLKK 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	p450	35..468	CDD:278495	129/446 (29%)
Cyp4a32	NP_001093651.1	p450	52..503	CDD:278495	139/498 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845117
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.650