DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4e3 and cyp4f3

DIOPT Version :9

Sequence 1:	NP_523527.1	Gene:	Cyp4e3 / 34291	FlyBaseID:	FBgn0015035	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001083010.1	Gene:	cyp4f3 / 100037390	ZFINID:	ZDB-GENE-070410-108	Length:	511	Species:	Danio rerio

Alignment Length:	546	Identity:	145/546 - (26%)
Similarity:	258/546 - (47%)	Gaps:	76/546 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LAVLALLVLPLITLVYFERKASQRRQLLKEFNGPTPVP--ILGNANRIGKNPAEILSTFFDWWYD 65
            |:|.||| ..|:|.:...|:|      |:.||.| |:.  |:|:...:|.| .|.|....|....
Zfish    13 LSVAALL-CALVTRIIINRRA------LRCFNQP-PLRNWIMGHMGLMGHN-EEGLQRVDDLVCK 68

  Fly    66 YGKDNFLFWIGYSSHIVMTNPKQLEYILN-SQQLIQKSTI-YDLLHPWLGHGLLTSFGSKWHKHR 128
            ||.....|...:.:.:.:.:|..:..:|. |..:..|..| |..:.||||:.||...|.:|.:||
Zfish    69 YGHSCSWFLGPFYNMVRLFHPDYIRSLLTASASITLKDRIFYGFMKPWLGNCLLLQSGQEWSRHR 133

  Fly   129 KMITPSFHFNILQDFHEVMNENSAKFMTQLKKASA-GDTIIDFQEHANYLTLDVI------CDTA 186
            :::||:|||:||:.:..:.|:::.....:.::..| |:..:|..|..:.||||.:      |||
Zfish   134 RLLTPAFHFDILKKYVHIFNQSTNIMHDEWRRLLAKGEHSVDMFEQISSLTLDSLLKCTFSCDT- 197

  Fly   187 MGVPINAMEQRDSSIVQAFRDMCYNINMRAFHPFKRSNRVFSLTPEFSAYQKTLKTLQDFTYDII 251
                  ..:::....:.|..|:...:..|..:.....:.::..:.:...:|:....:..||.||:
Zfish   198 ------HSQEKPRQYISAILDLSRLLVQRQHYLPYHWDWLYWRSAQGRRFQQACAVVHQFTADIV 256

  Fly   252 EKRVYALQNGGSKEDHDPSL----PRKKMAFLDTLLSSTID-GRPLTRQEIYEEVSTFMFEGHDT 311
            ::|...|......|.|..:.    .||....:|.||.:..| |..||.:||......|||.||||
Zfish   257 QERRTQLDQQSDPESHPENTGRYRKRKNTDLIDLLLLAKDDKGEGLTNEEIKAHADMFMFAGHDT 321

  Fly   312 TTSGVSFSVYLLSRHPDVQRKLYREQCEVMGHDM-----NRSVSFQEIAKMKYLDLFIKEAQRVY 371
            |.|.:|:..|.|:.:.|     |:|:|.....|:     ..::.:::::::.:..:.|||:.|::
Zfish   322 TASALSWIFYNLAMNQD-----YQERCRAEVRDLLADRDTHTIGWEDLSQLTFTTMCIKESLRLH 381

  Fly   372 PSVPFIGRYCDKDYDINGS-IVPKGTTLNLALILLGYNDRIFKDPHHFRPERFE---EEKPAPFE 432
            ..|..:.||..::....|. ::|.|....:::..:..|.:::.||..|.|.||:   .:..:|..
Zfish   382 SPVLALTRYYSQNMKTPGDCVIPHGCLCLISIYGVHRNPQVWPDPLVFDPTRFDPHNSDSRSPHA 446

  Fly   433 YLPFSAGPRNCIGQKFALLELKTVISKVVRSFEVLPAVDELVSTDGRLNTYLGLAPDEKLKREAG 497
            ::||||||||||||.||:.|:|.|::..:..|::||                |..|..:|.:
Zfish   447 FIPFSAGPRNCIGQNFAMAEMKVVVALTLARFKILP----------------GPKPVRRLYQ--- 492

  Fly   498 RHKYDPILSAVLTLKSDNGLHLRLRE 523
                       |.|:::.|:.|..:|
Zfish   493 -----------LVLRAEGGMILHFQE 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4e3	NP_523527.1	p450	35..468	CDD:278495	123/457 (27%)
cyp4f3	NP_001083010.1	p450	38..503	CDD:278495	131/508 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.010