DRSC/TRiP Functional Genomics Resources

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Protein Alignment ZNF404 and smc1b

DIOPT Version :9

Sequence 1:NP_001028891.2 Gene:ZNF404 / 342908 HGNCID:19417 Length:552 Species:Homo sapiens
Sequence 2:XP_031753497.1 Gene:smc1b / 100145425 XenbaseID:XB-GENE-997265 Length:1242 Species:Xenopus tropicalis


Alignment Length:464 Identity:88/464 - (18%)
Similarity:156/464 - (33%) Gaps:142/464 - (30%)


- Green bases have known domain annotations that are detailed below.


Human   108 SQMIFKKHKSLPLHKRNNTREKSYECKEYKKGFRKYLHLTEHLRDHTGVIPYECNECGKAFVVFQ 172
            :|..:.|.|:..:.:::.|.||: |...||.       |.::|:           |......::|
 Frog   182 AQFCYNKKKNAAVQRKHATLEKA-EADRYKA-------LQQNLK-----------ETKVELQLYQ 227

Human   173 HFIRHRKIHTDLKPYECNGCEK---AFRFYSQLIQHQIIHTGMKPYECKQCGKAFRRHSHLTEHQ 234
            .|...||:.:.::..|    ||   |.|...||::.:   :.:|. |..:.|:..|....:.:..
 Frog   228 LFHNERKLESVVRSLE----EKQSDANRQKEQLVRAE---SALKS-EKAELGRCTRDLQQIEKEI 284

Human   235 KI------HVGLKPFECKECGETFRLYRHMCLHQKIHHGVKPYKC--------KECGKAFGHRSS 285
            |:      |:..:..:.||              ...||..|....        |:|.|....:|.
 Frog   285 KVQEVSLSHLRPQFIKAKE--------------NTAHHLKKVETAKKNVANNEKQCHKLEQDKSE 335

Human   286 LYQHKKIHSGEKPY-----KCEQCEKAFVRSYLLVEHQRSHTGEKPHECMECGKAFGKGSSLLKH 345
            |  ..:|...|..:     |.|:..:..:....|.|.||....|...|..:......:....|:.
 Frog   336 L--ETEIEDIETAWRLFERKVEEDRQRRLGDIELEESQREQYRELKEEANKESAVLRQQLDRLQW 398

Human   346 KRIHSSEKLYDCKDCGKAFCRGSQLTQHQRIHTGEK--PHECKECGKTF-KLHSYLIQHQIIHTD 407
            ::..:.|||        .|.    ||:.:.:...:|  ..:.:|..|.. ||..|      |:|.
 Frog   399 EQKSAQEKL--------EFV----LTRQKEVQVNKKHVEEQIEEHNKRIEKLEEY------INTC 445

Human   408 LKPYECKQCGKAFSRVGDLKTHQSIHAGEKPYECKECGKTFRLNSQLIYHQTIHTGLKPYVCKEC 472
            ||..| :|..:.....|::|..:.              :...:|.||                  
 Frog   446 LKSIE-EQRPQEEQLAGEIKASKQ--------------RMVEINEQL------------------ 477

Human   473 KKAFRSISGLSQHKRI--HTGEKPYECKECDKAFNRSDRLTQHETIHTGVKPQKCKECGKAFSHC 535
                .||.|..|:.||  |.|.:.....|..::..|             :.|...  .|:.|..|
 Frog   478 ----NSIVGELQNARIDFHEGSRQKRKAEVLESMKR-------------MYPDAV--FGRLFELC 523

Human   536 YQLSQHQRF 544
            :.:  |:::
 Frog   524 HPI--HKKY 530

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ZNF404NP_001028891.2 KRAB 6..>51 CDD:214630
KRAB 6..45 CDD:279668
COG5048 106..510 CDD:227381 83/428 (19%)
C2H2 Zn finger 133..153 CDD:275368 4/19 (21%)
C2H2 Zn finger 161..181 CDD:275368 5/19 (26%)
C2H2 Zn finger 189..209 CDD:275368 6/22 (27%)
C2H2 Zn finger 217..237 CDD:275368 3/25 (12%)
C2H2 Zn finger 245..265 CDD:275368 2/19 (11%)
C2H2 Zn finger 273..293 CDD:275368 5/27 (19%)
zf-H2C2_2 285..310 CDD:290200 5/29 (17%)
C2H2 Zn finger 301..321 CDD:275368 5/19 (26%)
zf-H2C2_2 314..336 CDD:290200 6/21 (29%)
C2H2 Zn finger 329..349 CDD:275368 1/19 (5%)
C2H2 Zn finger 357..377 CDD:275368 3/19 (16%)
zf-H2C2_2 370..393 CDD:290200 5/25 (20%)
C2H2 Zn finger 385..405 CDD:275368 5/20 (25%)
CpXC 413..>458 CDD:291051 6/44 (14%)
C2H2 Zn finger 413..433 CDD:275368 3/19 (16%)
C2H2 Zn finger 441..461 CDD:275368 3/19 (16%)
C2H2 Zn finger 469..489 CDD:275368 6/21 (29%)
zf-H2C2_2 482..506 CDD:290200 6/25 (24%)
C2H2 Zn finger 497..517 CDD:275368 2/19 (11%)
C2H2 Zn finger 525..545 CDD:275368 4/20 (20%)
smc1bXP_031753497.1 Smc 3..1198 CDD:224117 88/464 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
NCBI 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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