Protein Alignment Pka-C1 and PKN1

DIOPT Version :10

• Sequence 1: NP_476977.1
• Gene: Pka-C1 / 34284
• FlyBaseID: FBgn0000273
• Length: 353
• Species: Drosophila melanogaster
• Sequence 2: NP_998725.1
• Gene: PKN1 / 5585
• HGNCID: 9405
• Length: 948
• Species: Homo sapiens
• Alignment Length: 315
• Identity: 122/315 - (38%)
• Similarity: 193/315 - (61%)
• Gaps: 11/315 - (3%)

  Fly    34 RRNPTNTAALDDFERIKTLGTGSFGRVMIVQHKPTKDYYAMKILDKQKVVKLKQVEHTLNEKRIL 98
            |::|   ..|:||:.:..||.|.||:|::.:.:|:.:.:|:|.|.|..:|...:||..:.|||||
Human   612 RKSP---LTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRIL 673

  Fly    99 QAIQ---FPFLVSLRYHFKDNSNLYMVLEYVPGGEMFSHLRKVGRFSEPHSRFYAAQIVLAFEYL 160
            .|:.   .||||:|...|:...::..|:||..||::..|:.. ..||||.:.||:|.:||..::|
Human   674 AAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHS-DVFSEPRAIFYSACVVLGLQFL 737

  Fly   161 HYLDLIYRDLKPENLLIDSQGYLKVTDFGFAKRVKG---RTWTLCGTPEYLAPEIILSKGYNKAV 222
            |...::|||||.:|||:|::||:|:.|||..|...|   ||.|.|||||:||||::....|.:||
Human   738 HEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAV 802

  Fly   223 DWWALGVLVYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFGSDLKDLLRNLLQVDLTKRYGNL 287
            |||.||||:|||..|..||..|...::::.||:.:||:|....::...::|.||:.:..:|.|:.
Human   803 DWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSS 867

  Fly   288 KAGVNDIKNQKWFASTDWIAIFQKKIEAPFIPRCKGPGDTSNFD-DYEEEALRIS 341
            :....|:|.|.:|.:..|.|:..:::..||:|...|..|.|||| ::..||..:|
Human   868 ERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRTDVSNFDEEFTGEAPTLS 922

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pka-C1	NP_476977.1	STKc_PKA	44..333	CDD:271111	116/295 (39%)
PKN1	NP_998725.1	HR1_PKN_1	<52..104	CDD:212012
		HR1_PKN1_2	127..202	CDD:212020
		HR1_PKN1_3	211..284	CDD:212026
		C2_PKN-like	395..482	CDD:176069
		STKc_PKN	621..945	CDD:270741	118/303 (39%)