DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pka-C1 and prkg2

DIOPT Version :9

Sequence 1:	NP_476977.1	Gene:	Pka-C1 / 34284	FlyBaseID:	FBgn0000273	Length:	353	Species:	Drosophila melanogaster
Sequence 2:	XP_002934043.3	Gene:	prkg2 / 100497736	XenbaseID:	XB-GENE-951552	Length:	787	Species:	Xenopus tropicalis

Alignment Length:	363	Identity:	144/363 - (39%)
Similarity:	211/363 - (58%)	Gaps:	33/363 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 TSNKKVDAAETVKEFLE--QAKEEFEDKWR--RNPTN-----------------------TAALD 44
            |.||.|...|.:.:.||  .|....:|:.|  ::|.|                       .:..:
Frog   412 TFNKTVGTYEELMKCLEGYVANLTLDDERRHAKSPVNERHLRAVSMELNKMKQTLARFPSASPFE 476

  Fly    45 DFERIKTLGTGSFGRVMIVQHKPTKDYYAMKILDKQKVVKLKQVEHTLNEKRILQAIQFPFLVSL 109
            :.|.:.|||.|.||||.:|:.|.....:|:|.:.|:.:|..:|.||..:||.||:....||:|.|
Frog   477 NLEIVTTLGVGGFGRVELVKVKNENLVFALKCIKKRHIVDNRQQEHIHSEKNILEEACSPFIVKL 541

  Fly   110 RYHFKDNSNLYMVLEYVPGGEMFSHLRKVGRFSEPHSRFYAAQIVLAFEYLHYLDLIYRDLKPEN 174
            ...||||..:||:||...|||::|.||..|.|.||.::|....:..||||||...::||||||||
Frog   542 YCTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTAKFCTGCVTEAFEYLHQKGVLYRDLKPEN 606

  Fly   175 LLIDSQGYLKVTDFGFAKRV--KGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLVYEMAAG 237
            ||:||:||:|:.||||||::  ..:|||.||||||:|||:||:||::.:||:|:||:|:||:..|
Frog   607 LLLDSEGYVKLVDFGFAKKIFPGQKTWTFCGTPEYVAPEVILNKGHSFSVDFWSLGILLYELLTG 671

  Fly   238 YPPFFADQPIQIYEKIVSG--KVRFPSHFGSDLKDLLRNLLQVDLTKRYGNLKAGVNDIKNQKWF 300
            .|||.....:.||..|:.|  |:.|..:.....:||:|.|.:.:..:|.||:|.|:.|||..:||
Frog   672 SPPFTGPDQMIIYNLILQGIEKIEFYKNITKRPEDLIRRLCRENPAERLGNMKNGIADIKKHRWF 736

  Fly   301 ASTDWIAIFQKKIEAPFIPRCKGPGDTSNFDDY--EEE 336
            ...:|..:..:.:.:|..|..:||.|.|.||.|  :||
Frog   737 NGFNWEGLNTRSLPSPLKPELEGPTDHSYFDSYPPDEE 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pka-C1	NP_476977.1	STKc_PKA	44..333	CDD:271111	129/292 (44%)
prkg2	XP_002934043.3	CAP_ED	194..303	CDD:237999
		CAP_ED	312..427	CDD:237999	5/14 (36%)
		STKc_cGK	484..743	CDD:270724	119/258 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910