Protein Alignment Apoltp and vtg2

DIOPT Version :9

• Sequence 1: NP_995670.2
• Gene: Apoltp / 34283
• FlyBaseID: FBgn0032136
• Length: 4333
• Species: Drosophila melanogaster
• Sequence 2: NP_001038378.1
• Gene: vtg2 / 559931
• ZFINID: ZDB-GENE-001201-2
• Length: 1631
• Species: Danio rerio
• Alignment Length: 1853
• Identity: 336/1853 - (18%)
• Similarity: 632/1853 - (34%)
• Gaps: 513/1853 - (27%)

  Fly    49 EQLYKYQYTVAVRTEFAGSGDNSSDLLLKSDLEIFFPKPCEGYLRINDAKLYDTLDELNDNESDS 113
            ::.|.|:|...:.:.....|...:.:.:||.:.:                            |.:
Zfish    27 DKTYVYKYEALLLSGIVQEGLAKAGIQIKSKVLL----------------------------SAA 63

  Fly   114 SEKTKEYDYYDNLANEESESQNYDNMHPKSSDFNVDLTKNL---LRFAFHDGLISEVCPQEQETP 175
            :|.|....:.|.|..|.:.:...|.:.| ::..|..|...|   ::|.:.:|::.:|......:|
Zfish    64 TENTFLLKFVDPLFYEYAGTWPKDQVFP-ATKLNSALAAQLQTPIKFEYANGVVGKVFAPAGVSP 127

  Fly   176 WVLNIKKGILSAFQNTMMRFDVDANTTETDVSGQCQVQYAL-EDTDSSYVTIRKTKDINSCRQRY 239
            .|||:.:|||:..|....:........|....|.|:.||.: ||..:..:|:.|::|::.|::|.
Zfish   128 SVLNLYRGILNILQLNFKKTQNIYELQEAGAQGVCKTQYVISEDPKADRITVTKSRDLSHCQERI 192

  Fly   240 ATHSVLQTTPYTFRDDKTIWPILKSQSHCNLTIDNNVYK---------EIKCLETHLLVPFSNAS 295
            .....|..|.......|.|..::::.::      |.:.|         |....|.|...||:...
Zfish   193 VKDIGLAYTETCVECTKRIKSLIETANY------NYIIKPSDSGALIAEATVKEVHQFSPFNEIH 251

  Fly   296 SGALTTSTSRL-------------KLD----GVESYS-AGEFLEQNPELVERRATLVFDHTPAVK 342
            ..|:..:|..|             |.|    |...|. |.|.|:...:|.:      ..:.||
Zfish   252 GAAMMEATQSLVFVEFEKAPVVPVKADYMPRGSLQYEFATEILQTPIQLTK------ISNAPA-- 308

  Fly   343 PSHDEIKAARELLVEMCRVGFPNIQREFIDVFTNFLQTSKSLDYKTLSVLLQRSASTCEQG--RN 405
                :||...:.|||      .|:.....|....|:|..:.|...||.......|...::.  |.
Zfish   309 ----QIKEVLKHLVE------NNVAMVHDDAPLKFVQLVQFLRAATLKDTEAIWAQFKDKPVYRR 363

  Fly   406 HLLESLPFIGSTASYKVMRDQIINEKLT-KQMAHDWMTALSFITRPDEETLETFHSILEYAK--- 466
            .||::||.:.:....|.::::.:..:.| .:.....:.||..:. .|.||::...|:..:.|
Zfish   364 WLLDTLPAVATPVVLKFIKEKFLAGEFTLTEFIPTLVVALQMVP-ADLETIQWTASLALHEKIAT 427

  Fly   467 -NRLDAEYTLGATAVVHSFCKHHEACEENLRVQQIINLLETEFLNLYNLFKGERRTRERMVILLK 530
             ..|.....||..:::..:|.....|...|  .:.|:.:.||.::..::        ..:.:.||
Zfish   428 IPALREVVMLGYGSMIAKYCVAVPTCPAEL--LRPIHEIATEAISKNDI--------PEITLALK 482

  Fly   531 GLGNIGVVSSAFAEQLQWIIR--------EDEAPVDIRLHGILAFRRVDCARHRSYFLDNYG--- 584
            .|||.|..||     |:.|::        ....|:.:::..|||.|.:  |:.....:....
Zfish   483 VLGNAGHPSS-----LKPIMKLLPVLKTTASALPIRVQVDAILALRSI--AKKEPKLVQPVALQL 540

  Fly   585 --NYTLNSELRIYSYLQAMRCPDYISVGVIKSI---LEHEEINQVGSFVWSHLTNLAKSNSPVRI 644
              ...|:.|||:.:.:.......  ||.|:.|:   |..|...||.||.:||:.:|.:..:|...
Zfish   541 VLERALHPELRMVACILLFETKP--SVAVMSSLAGALRMETNMQVASFAYSHIKSLTRITAPDMS 603

  Fly   645 EAQGL------LLNDELSERFKMDIRKFSRNYEHSLFFDEYNFGTTTDANVIFGTDSYLPRIASV 703
            ...|.      |:|.:|.   :::.| :||.::...:......|....|.:|....:.|||....
Zfish   604 SVAGAANVAIKLMNRKLD---RLNFR-YSRAFQLDFYHTPLMIGAAGSAYMINDAATILPRAVIA 664

  Fly   704 NFTADLFGQSVNFFEFTARAEGLEELAANAFGPKGPLSGQLLRKKLSFLNRWLGNESAEEDDTLE 768
            ...|.|.|.:.:..||..|.||::|...     |.|
Zfish   665 KARAYLAGAATDVIEFGLRTEGIQEALL-----KSP----------------------------- 695

  Fly   769 NLLSLDNLRLKRKAQEQARASEEEVDEDYDFEESLEGNKRQKRDVSTTRKQEIDRNVDSLGYKLK 833
                               |::|.||                      |..:|.|.:.:|.....
Zfish   696 -------------------AADESVD----------------------RITKIKRTLRALTNWKA 719

  Fly   834 YDYNNPRAQFGLRVFGNDLRYFNVESLVEVMALAAKFNPFQQA------KNVLSGKEFTYTKSRV 892
            ...|.|.|...::|||.::.:..::..:...||.....|..:|      |.:..|..:...|..:
Zfish   720 MPSNKPLASAYVKVFGQEMAFGRIDKTIIEQALPMVNGPKPRALLKEALKALQEGISWQRAKPLL 784

  Fly   893 FLDASYTVPLAVGLPLAIHAF----GASSIDLRVSGNLDEMDPP---------------TDWHFD 938
            ..:....:|.:||||:.:..:    ||::::::.:     :.||               ||..|.
Zfish   785 VAEVRRILPTSVGLPMELSMYSSVVGAATVNVQAT-----ITPPLPEQIETMTLEQLKKTDVQFK 844

  Fly   939 VEGQFKPSVSVDVITTMQTDMFWEQSGIKVKSNLYSNSELVAKLKVRGR--------NLVSFSFD 995
            .|.  :||:::.....|..:..:.|:.:..:..:    ..:|..||..|        .:.:...:
Zfish   845 AEA--RPSIAIHKFAVMGVNTAFIQAAVMARGKI----RTIAPGKVAARADILKGNYKIEALPVE 903

  Fly   996 LPRDKNEIFSVRSELLVQKREEQLPQAGIANRSANSTCTWPVLDQAIGLQMCSHYSVPDLSNATE 1060
            ||   ..|.|...|.....|:.:.|.|                ::.:.|     .||..|.|.
Zfish   904 LP---EHIASASFETFAFARDVEDPSA----------------ERTVPL-----VSVLSLQNR-- 942

  Fly  1061 IYPSLLLAGPLNFSLILKKSDLSAKKYVFEYKWDQQEEDNNFSLVFTTPGSKVPRVLVANVTKVP 1125
                             :...||:             |:.:..:...||            .|.|
Zfish   943 -----------------QSQRLSS-------------ENADSEIETETP------------VKAP 965

  Fly  1126 DAFNASVAFVNGPNRVSAGCSYDGNPDFRRLDIYLDTNGNRSLDLGMELRRHQDFTAWIYNPRML 1190
            ..|:.::.:. .|.....||                          :|:..|.  .|:|.|..:.
Zfish   966 APFDRTLCYA-VPYIEIKGC--------------------------VEVHSHN--AAFIRNSTLF 1001

  Fly  1191 LAINGVNITGLAGTVKVNEKNGIKQHDVDLSFETKKLQAVIKG-NVVQSEITTSTNMTIKYRFQA 1254
            ..| |.:....|  |...|...:::.:.::....:..:.:.|. |::..|.....:..:|.|
Zfish  1002 YII-GQHSARAA--VARAEGPAVEKLEFEVQVGPRAAERLAKQINIIDDETPEGKDFLLKLR--- 1060

  Fly  1255 NKIEEINFAGKLVNNGDKSKTEYRGNMKLQTSAYPKLNFASESTWLSLQGHTEGMITYNNAPDYV 1319
                      :::....|:.|...|:...::|:..:.:.:|.||
Zfish  1061 ----------EILETESKNATVSSGSSSSRSSSSSRSSSSSSST--------------------- 1094

  Fly  1320 NPNYTSLVRLIFARSHSEDSFLDGTQTRASLELKLPRSKID-YRILVKHKEHIKNGTEHNVIVGL 1383
             .|.||      :.|.|..|....:.:|.|..|    :|:: :|..  ||:..|  |.|.
Zfish  1095 -SNSTS------SSSSSSSSSSSMSSSRWSKTL----TKMEAFRKF--HKDQYK--THHG----- 1139

  Fly  1384 KYTPEKEITGLFSVHLPRRNLFAIDAYMNVTVPE-FNSCTASLKVNEKATKDYIIFINGSWFTGH 1447
             .:.....||.....:.:::     .|:..|||. |.....:::|:.|        :.|..|.
Zfish  1140 -DSKSSRSTGSSLEQIQKQS-----RYLGNTVPPVFAIIARAVRVDRK--------LLGYQFV-- 1188

  Fly  1448 SVAVKANYKDRSSRVQALHHLKMIVESPSFNITSLNIIYRRKQLL--IFYDIQAKYDQDPYGLTI 1510
                 |.:...|||||.:  ...|.|:.:|...:..::..:.::.  :.:..:.|    .|.:|
Zfish  1189 -----AFFDKPSSRVQFI--ASSIAENDNFKFCADGVLLSKHKVTSKVTWGAECK----EYAVT- 1241

  Fly  1511 QYASNAHNRNTNAEVRLKVKERDYWINAKLLSEQPKLLQLEIHMDKIRDV----------HIQVG 1565
                      |.||             |.||.|.| ..:||...:::..:          ||.:.
Zfish  1242 ----------TKAE-------------AGLLGEFP-AFRLEWEWERLPIIFTTYAKKLSKHIPMA 1282

  Fly  1566 LL----NVDKRKELSLELKWDANRDPSQRLGLLAEYNSPGTKHYDGNLMITYPER-----TIHFG 1621
            .|    ||::.|....||:........:.|.::...........|..|.:|:|..     .:||.
Zfish  1283 ALQAGFNVERAKNSEKELELTVALPSKRTLNVIVRVPEMTMSRMDIPLPVTFPINPDGTFDVHFY 1347

  Fly  1622 FNSFTGGPKY---FGKVHASWSINEVIEFEYEAGILPGHTLHNWVKAELRTPFDGWRVNSLDAGI 1683
            .:.:.....|   :.....|...:.:..|.           :...|.|:  |...::|.:.|. .
Zfish  1348 EDIYFRAQNYIYDYTTAQCSMMQDTISTFN-----------NKTYKNEM--PISCYQVLAQDC-T 1398

  Fly  1684 YSLKNLILVNSTLFWADDQKLQVGYK-SDYDVNDQLMSFDVRFGINSTIRDIPTINVKVKH---W 1744
            ..||.:.|:...   .:.:|..:..| .|.|::...:..|.:..||..  ::|..::..:|   .
Zfish  1399 SELKFVALLKKD---EESEKTHLNVKLVDIDIDLYTLGTDAKVKINGL--EVPISSLPYQHPSGS 1458

  Fly  1745 MDVKKVDTELYLGYSGQNDTFNTYSMDSSWEIE 1777
            :.:::....|.| |:........|..:..|:|:
Zfish  1459 IQIREKADGLSL-YAPSLGLHEVYFANGDWKIQ 1490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Apoltp	NP_995670.2	LPD_N	49..633	CDD:214755	132/637 (21%)
		DUF1943	665..1012	CDD:286281	66/379 (17%)
		DUF1081	1029..1122	CDD:283982	10/92 (11%)
		VWD	3741..3908	CDD:295339
		C8	3951..4014	CDD:285899
vtg2	NP_001038378.1	Vitellogenin_N	24..592	CDD:279663	132/637 (21%)
		DUF1943	626..917	CDD:286281	67/380 (18%)
		DUF1944	1167..1331	CDD:286284	37/209 (18%)
		VWD	1362..1519	CDD:214566	25/149 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	74	1.000	Domainoid score	I9069
eggNOG	1	0.900	-	-		E1_KOG4338
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23345
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.910