DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Apoltp and vit-4

DIOPT Version :9

Sequence 1:	NP_995670.2	Gene:	Apoltp / 34283	FlyBaseID:	FBgn0032136	Length:	4333	Species:	Drosophila melanogaster
Sequence 2:	NP_508612.1	Gene:	vit-4 / 180646	WormBaseID:	WBGene00006928	Length:	1603	Species:	Caenorhabditis elegans

Alignment Length:	1527	Identity:	295/1527 - (19%)
Similarity:	541/1527 - (35%)	Gaps:	449/1527 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 DLTKNLLRFAF----HDGLISEVCPQEQETPWVLNIKKGILSAF-------------QNTMMRFD 196
            |..|.||...|    .:||:||:....::..|..|.|:.||:.|             ....|..|
Worm   101 DELKELLELPFRAQIRNGLVSEIQFSSEDAEWSKNAKRSILNLFSLRKSAPVDEMSQDQKDMESD 165

  Fly   197 VDA---NTTETDVSGQCQVQYAL--EDTDSSYVTIRKTKDIN--SCRQRYATHSVL--------- 245
            .|:   |..|..:.|.|:|.|.:  |...:.|     ||.:|  .|..|..|...|
Worm   166 KDSLFFNVHEKTMEGDCEVAYTIVQEGGKTIY-----TKSVNFDKCITRPETAYGLRFGSECKEC 225

  Fly   246 ---------QTT-PYTFRDDKTIWPILKSQSHCNLTIDNNVYKEIKCLETHLLVPFSNAS----- 295
                     ||. .|||:::|    :.:|:.:...|::.|..:.:|. ||...|.|...|
Worm   226 EKEGQFVQPQTVYTYTFKNEK----LQESEVNSIYTLNVNGQEVVKS-ETRAKVTFVEESKINRE 285

  Fly   296 ----SG---ALTTSTSRLKLDGVES-YSAGEFLEQNP----------ELVERRATLVFDH---TP 339
                ||   .:..|....||  :|. |..|:..|.||          |.:|.....:.:|   ||
Worm   286 IKKVSGPKEEIVYSMENEKL--IEQFYKQGDKAEVNPFKAIEIEQKVEQLEEIFRQIQEHEQNTP 348

  Fly   340 AVKPSHDEIKAARELLVEMCRVGFPNIQREFIDVFTNFLQTSKSLDYKTLSVLLQRSASTCEQGR 404
              :..|...:|.|  :..||.:  ..:::....::|...:..:.:...||:|     |.| :...
Worm   349 --ETVHLIARAVR--MFRMCTI--EELKKVHTTIYTKAEKKVQLVIETTLAV-----AGT-KNTI 401

  Fly   405 NHLLESLPFIGSTASYKVMRDQIINEKLTKQMAHDWMTALSFITRPDEETLETFHSILEYAKNRL 469
            .||:....                .:.:|...|.:.:.::.....|.|...:.   :::.|::.|
Worm   402 QHLIHHFE----------------KKSITPLRAAELLKSVQETLYPSEHIADL---LIQLAQSPL 447

  Fly   470 DAEYT-------LGATAVVHSFCKHHEACEENLRVQQIINLLETEFLNLYNLFKGERRTRER--- 524
            ..:|.       |.|.:||..|..                  :|:.|.|  :....|:|:|:
Worm   448 SEKYEPLRQSAWLAAGSVVRGFAS------------------KTQDLPL--IRPASRQTKEKYVR 492

  Fly   525 --------------MVILLKGLGNIGVVSSAFAEQLQWIIREDEAPVDIRLHGILAFRRVDCARH 575
                          .|:.||.|||.|:..|.:  :|..:|::...|:.||...:.|.|.:.....
Worm   493 VFMQHFRNADSTYEKVLALKTLGNAGIDLSVY--ELVQLIQDPRQPLSIRTEAVDALRLLKDVMP 555

  Fly   576 R---SYFLDNYGNYTLNSELRIYSYLQAMR-CPDYISVGVIKSILEHEEINQVGSFVWSHLTNLA 636
            |   ...|..|.|.....|||:.:..:.|. .|:...:..|.|.:|:|....|.:|.::.|...:
Worm   556 RKIQKVLLPVYKNRQNKPELRMAALWRMMHTIPEEPVLAHIVSQMENESNQHVAAFTYNVLRQFS 620

  Fly   637 KSNSP----VRIEAQGLLLNDELSERFKMDIRKFSRNYEHSLFFDEYNFGTTTDANVIFGTDSYL 697
            ||.:|    :.:....:|    |..|::...:..|...:..||..|:..|...|...||..:::|
Worm   621 KSTNPCYQQLAVRCSKVL----LFTRYQPQEQMLSTYSQLPLFNSEWLSGVQFDFATIFEKNAFL 681

  Fly   698 PRIASVNFTADLFGQSVN--FFEFTARAEGLEELAANAFGPKGPLSGQLLRKKLSFLNRWLGNES 760
            |:....:|.. :||.:.|  |.:.....:..|               |::.|.|..|:.: |.:|
Worm   682 PKEVQASFET-VFGGNWNKYFAQVGFSQQNFE---------------QVILKTLEKLSLY-GKQS 729

  Fly   761 AEEDDTLENLLSLDNLRLKRKAQEQARASEEEVDEDYDFEESLEGNKRQKRDVSTTRKQEIDRNV 825
                         |.|| .|:.|...:..:|.|               :|.::....:|...:|.
Worm   730 -------------DELR-SRRVQSGIQMLQEIV---------------KKMNIRPRVQQTDSQNA 765

  Fly   826 DSLGYKLKY---DYNNPRAQFGLRVFGNDLRYFNVESLVEVMALAAKFNPFQQAKNVLSGKEFTY 887
            .::.| |:|   ||         .|...|:.  .::::||......:|:.......:.:..:|..
Worm   766 HAVFY-LRYKEMDY---------IVLPIDME--TIDNVVEKYVRNGEFDIKSLLTFLTNDSKFEL 818

  Fly   888 TKSRVFLDASYTVPLAVGLPLAIHA--------FGASSIDLRVSGNLDEMDPPTDWHFDVEGQFK 944
            .::..|.:|...:|..:|:||.|..        .|..||:|...|....:|            ..
Worm   819 HRALFFYEAERRIPTTIGMPLTISGKMPTILSINGKVSIELEKLGARLVLD------------IV 871

  Fly   945 PSVSVDVITTMQTDMFWE---QSGIK--VKSNLYSNSELVAKLKVRGRNL-VSFSFDLPRDKNEI 1003
            |:|:...:|.|:   ||.   :.|:|  ..:.|::.....:.::::...| ::..|.:|.:|...
Worm   872 PTVATTHVTEMR---FWYPVIEQGVKSLQSARLHTPLRFESTVELKKNTLEITHKFVVPENKKTT 933

  Fly  1004 FSVRS-----------------------------ELLVQKREEQLPQAGI-ANRSANSTCTWPVL 1038
            .||.:                             ::..::.:.|....|: .|...|....| .|
Worm   934 VSVHTRPVAFIRVPKNQDSEYVEAEEKTISHSQYQMSTEEIDRQYETFGLRINAQGNVLSQW-TL 997

  Fly  1039 DQAIGLQMCSHYSVPDLSNATEIYPSLLLAGPLNFSLILKKSDLSAKKY--VFEYKWD-QQEEDN 1100
            ...:..:....:::.:.:...|....:.:..       |:|:|||..|:  :||.::| :..|..
Worm   998 PMVLMTEQDFEFTLENKNRPVEFTARVTIGN-------LEKTDLSEIKFDKIFEKEFDLENNESE 1055

  Fly  1101 NFSLVFTTPGSKVPRVLVANVTKVPDAFNASVAFVNGPNRVSAGCSYDGNPDFRRL-DIYLDTNG 1164
            |....|        ..::..:.......|.....:..|.::.      .|.:.|.: |.::
Worm  1056 NRRQYF--------HKMIREIQSEQGFKNLITLKLEAPQQMY------WNTELRTVCDKWI---- 1102

  Fly  1165 NRSLDLGMELRR----HQDFTAWIYNPRMLLAINGVNITGLAGTVKVNEKNGIKQ------HDVD 1219
             |...:.|:.||    |:: ..|.....:|.|             :....:.::|      .:|.
Worm  1103 -RMCKVEMDARRSPIEHEN-KEWTLRTELLAA-------------RPQMPSSLRQLREQPHREVQ 1152

  Fly  1220 LSFETKKLQAVIKGNVVQSEITTSTNMTIKYRFQANKIEEINFAGKLVNNGDKSKTEYRG----N 1280
            |:...|      .|:..:||||          |.| ::|:.....|.:.|.::   ||:|    .
Worm  1153 LALNAK------WGSSKKSEIT----------FNA-QLEQSTEQKKFLRNIER---EYKGIPEYE 1197

  Fly  1281 MKLQTSAYPKLNFASESTWLSLQGHTEGMITYNNAPDYVNP-NYTSLVRLIFARSHSEDSFLDGT 1344
            :.::.:...::|..||   ..|...:|  .|::...|.:.. |:.::..   .|..:||
Worm  1198 LLIKAARLNQVNVVSE---YKLTPESE--YTFSRIFDLIKAYNFWTVSE---KRVQNED------ 1248

  Fly  1345 QTRASLELKL-PRSKIDYRILVKHKEHIKNGTEHNVIVGLKYTPEKEITGLFSVHLPRRNLFAID 1408
             .|..|:|.: |.|:....:.::                   |||:|:. |.:|.:||
Worm  1249 -RRVVLQLSVEPLSRQYMNMTIQ-------------------TPEQEVE-LKNVRIPR------- 1285

  Fly  1409 AYMNVTVP------------EFNSCTASLKVNEKATKDYIIFINGSWFTGHSVAVKANYKDRSSR 1461
                |.:|            |....|..:..:|.:|.|.:|: .....|.:|:..    ||.|
Worm  1286 ----VVLPTIARRAMFQQTWEKTGATCKVDQSEVSTFDNVIY-RAPLTTCYSLVA----KDCS-- 1339

  Fly  1462 VQALHHLKMIVESPSFNITSLNIIYRRKQLLI 1493
                       |.|.|.:.:..|....::||:
Worm  1340 -----------EQPRFAVLAKKINKNSEELLV 1360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Apoltp	NP_995670.2	LPD_N	49..633	CDD:214755	125/580 (22%)
		DUF1943	665..1012	CDD:286281	71/394 (18%)
		DUF1081	1029..1122	CDD:283982	16/95 (17%)
		VWD	3741..3908	CDD:295339
		C8	3951..4014	CDD:285899
vit-4	NP_508612.1	Vitellogenin_N	24..617	CDD:279663	125/580 (22%)
		DUF1943	651..942	CDD:286281	71/363 (20%)
		VWD	1300..1454	CDD:214566	17/79 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I7810
eggNOG	1	0.900	-	-		E1_KOG4338
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23345
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910