DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Apoltp and vit-5

DIOPT Version :9

Sequence 1:	NP_995670.2	Gene:	Apoltp / 34283	FlyBaseID:	FBgn0032136	Length:	4333	Species:	Drosophila melanogaster
Sequence 2:	NP_508589.1	Gene:	vit-5 / 180630	WormBaseID:	WBGene00006929	Length:	1603	Species:	Caenorhabditis elegans

Alignment Length:	1756	Identity:	341/1756 - (19%)
Similarity:	614/1756 - (34%)	Gaps:	537/1756 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 YKYQYTVAVRTEFAGSGDNSSDLLLKSDLEIFFPKPCEGYLRINDAKLYDTLDELNDNESDSSE- 115
            |.|::...:.:....:..::|..|:.          |...|:..|.: |..| :|.|.:..:|.
Worm    30 YVYKFDGLLLSGLPTASSDASQTLIS----------CRTRLQAVDDR-YIHL-QLTDIQYSASHI 82

  Fly   116 -KTKEYDYYDNLANEESESQNYDNMHPKSSDFNVDLTKNLLRFAF----HDGLISEVCPQEQETP 175
             :::::...::|...|           .|.:|     |.||...|    .:|||||:....::..
Worm    83 PQSEQWPKIESLEQRE-----------LSDEF-----KELLELPFRAQIRNGLISEIQFSSEDAE 131

  Fly   176 WVLNIKKGILSAF-------------QNTMMRFDVDA---NTTETDVSGQCQVQYAL--EDTDSS 222
            |..|.|:.||:.|             ....|..|.|:   |..|..:.|.|:|.|.:  |...:.
Worm   132 WSKNAKRSILNLFSLRKSAPVDEMNQDQKDMESDKDSLFFNVHEKTMEGDCEVAYTIVQEGEKTI 196

  Fly   223 YVTIRKTKDIN--SCRQRYATHSVL------------------QTT-PYTFRDDKTIWPILKSQS 266
            |     ||.:|  .|..|..|...|                  ||. .|||:::|    :.:|:.
Worm   197 Y-----TKSVNFDKCITRPETAYGLRFGSECKECEKEGQFVKPQTVYTYTFKNEK----LQESEV 252

  Fly   267 HCNLTIDNNVYKEIKCLETHLLVPFSNAS---------SG---ALTTSTSRLKLDGVES-YSAGE 318
            |...|::.|..:.:|. ||...|.|...|         ||   .:..|....||  :|. |..|:
Worm   253 HSVYTLNVNGQEVVKS-ETRAKVTFVEESKINREIKKVSGPKEEIVYSMENEKL--IEQFYQQGD 314

  Fly   319 FLEQNP----ELVERRATL--VF-------DHTPAVKPSHDEIKAARELLVEMCRVGFPNIQREF 370
            ..|.||    |:.::...|  :|       .:||  :..|...:|.|  :..||.:  ..:::..
Worm   315 KAEVNPFKAIEMEQKVEQLQEIFRQIQEHEQNTP--ETVHLIARAVR--MFRMCTI--EELKKVH 373

  Fly   371 IDVFTNFLQTSKSLDYKTLSVLLQRSASTCEQGRNHLLESLPFIGSTASYKVMRDQIINEKLTKQ 435
            ..::|...:..:.:...||:|     |.| :....||:....                .:.:|..
Worm   374 TTIYTKAEKKVQLVIETTLAV-----AGT-KNTIQHLIHHFE----------------KKSITPL 416

  Fly   436 MAHDWMTALSFITRPDEETLETFHSILEYAKNRLDAEYT-------LGATAVVHSFCKHHEACEE 493
            .|.:.:.::.....|.|...:.   :::.|::.|..:|.       |.|.:||..|..
Worm   417 RAAELLKSVQETLYPSEHIADL---LIQLAQSPLSEKYEPLRQSAWLAAGSVVRGFAS------- 471

  Fly   494 NLRVQQIINLLETEFLNLYNLFKGERRTRER-----------------MVILLKGLGNIGVVSSA 541
                       :|:.|.|  :....|:|:|:                 .|:.||.|||.|:..|.
Worm   472 -----------KTQDLPL--IRPASRQTKEKYVRVFMQHFRNADSTYEKVLALKTLGNAGIDLSV 523

  Fly   542 FAEQLQWIIREDEAPVDIRLHGILAFRRVDCARHR---SYFLDNYGNYTLNSELRIYSYLQAMR- 602
            :  :|..||::...|:.||...:.|.|.:.....|   ...|..|.|.....|||:.:..:.|.
Worm   524 Y--ELVQIIQDPRQPLSIRTEAVDALRLLKDVMPRKIQKVLLPVYKNRQNKPELRMAALWRMMHT 586

  Fly   603 CPDYISVGVIKSILEHEEINQVGSFVWSHLTNLAKSNSP----VRIEAQGLLLNDELSERFKMDI 663
            .|:...:..|.|.:|:|....|.:|.::.|....||.:|    :.:....:|    |..|::...
Worm   587 IPEEPVLAHIVSQMENESNQHVAAFTYNVLRQFYKSTNPCYQQLAVRCSKIL----LFTRYQPQE 647

  Fly   664 RKFSRNYEHSLFFDEYNFGTTTDANVIFGTDSYLPRIASVNFTADLFGQSVN--FFEFTARAEGL 726
            :..|...:..||..|:..|...|...||..:::||:....:|.. :||.:.|  |.:.....:..
Worm   648 QMLSTYSQLPLFNSEWLSGVQFDFATIFEKNAFLPKEVQASFET-VFGGNWNKYFAQVGFSQQNF 711

  Fly   727 EELAANAFGPKGPLSGQLLRKKLSFLNRWLGNESAEEDDTLENLLSLDNLRLKRKAQEQARASEE 791
            |               |::.|.|..|:.: |.:|             |.|| .|:.|...:..:|
Worm   712 E---------------QVILKTLEKLSLY-GKQS-------------DELR-SRRVQSGIQMLQE 746

  Fly   792 EVDEDYDFEESLEGNKRQKRDVSTTRKQEIDRNVDSLGYKLKY---DYNNPRAQFGLRVFGNDLR 853
            .|               :|.::....:|...:|..::.| |:|   ||         .|...|:.
Worm   747 IV---------------KKMNIRPRVQQTDSQNAHAVFY-LRYKEMDY---------IVLPIDME 786

  Fly   854 YFNVESLVEVMALAAKFNPFQQAKNVLSGKEFTYTKSRVFLDASYTVPLAVGLPLAIHA------ 912
              .:::|||......:|:.......:.:..:|...::..|.:|...:|..:|:||.|..
Worm   787 --TIDTLVEKYVRNGEFDIKSLLTFLTNDSKFELHRALFFYEAERRIPTTIGMPLTISGKMPTIL 849

  Fly   913 --FGASSIDLRVSGNLDEMDPPTDWHFDVEGQFKPSVSVDVITTMQTDMFWE---QSGIK--VKS 970
              .|..||:|...|....:|            ..|:|:...:|.|:   ||.   :.|:|  ..:
Worm   850 SINGKVSIELEKLGARLVLD------------IVPTVATTHVTEMR---FWYPVIEQGVKSLQSA 899

  Fly   971 NLYSNSELVAKLKVRGRNL-VSFSFDLPRDKNEIFSVRS-------------------------- 1008
            .|::.....:.::::...| ::..|.:|.:|....||.:
Worm   900 RLHTPLRFESTVELKKNTLEITHKFVVPENKKTTVSVHTRPVAFIRVPKNQDSEYVEAEEKTISH 964

  Fly  1009 ---ELLVQKREEQLPQAGI-ANRSANSTCTWPVLDQAIGLQMCSHYSVPDLSNATEIYPSLLLAG 1069
               ::..::.:.|....|: .|...|....| .|...:..:....|::.:.:...|....:.:..
Worm   965 SQYQMSTEEIDRQYETFGLRINAQGNVLSQW-TLPMVLMTEQDFEYTLENKNRPVEFTARVTIGN 1028

  Fly  1070 PLNFSLILKKSDLSAKKY--VFEYKWD-QQEEDNNFSLVFTTPGSKVPRVLVANVTKVPDAFNAS 1131
                   |:|:|||..|:  :||.::| :..|..|....|        ..::..:.......|..
Worm  1029 -------LEKTDLSEIKFDKIFEKEFDLENNESENRRQYF--------HKMIREIQSEQGFKNLI 1078

  Fly  1132 VAFVNGPNRVSAGCSYDGNPDFRRL-DIYLDTNGNRSLDLGMELRR----HQDFTAWIYNPRMLL 1191
            ...:..|.::.      .|.:.|.: |.::     |...:.|:.||    |:: ..|.....:|.
Worm  1079 TLKLEAPQQMY------WNTELRTVCDKWI-----RMCKVEMDARRSPMEHEN-KEWTLRTELLA 1131

  Fly  1192 AINGVNITGLAGTVKVNEKNGIKQ------HDVDLSFETKKLQAVIKGNVVQSEITTSTNMTIKY 1250
            |             :....:.::|      .:|.|:|..|      .|:..:||||.:.
Worm  1132 A-------------RPQMPSSLRQLREQPHREVQLAFNAK------WGSSKKSEITVNA------ 1171

  Fly  1251 RFQANKIEEINFAGKLVNNGDKSKTEYRG----NMKLQTSAYPKLNFASESTWLSLQGHTEGMIT 1311
                 ::|:.....|.:.|.::   ||:|    .:.::.:...::|..||
Worm  1172 -----QLEQSTEQKKFIRNIER---EYKGIPEYELLIKAARLNQVNVVSE--------------- 1213

  Fly  1312 YNNAP--DYVNPNYTSLVRLIFARSHSEDSFLDGTQTRASLELKL-PRSKIDYRILVKHKEHIKN 1373
            |...|  :|.......|::.....:.||.. :.....|..|:|.: |.|:....:.::
Worm  1214 YKLTPQSEYTFSRIFDLIKAYNFWTVSEKR-VQNENRRVVLQLSVEPLSRQYMNMTIQ------- 1270

  Fly  1374 GTEHNVIVGLKYTPEKEITGLFSVHLPRRNLFAIDAYMNVTVPEFNSCTASLKVNEKATKDYIIF 1438
                        |||:|:. |.:|.:||           |.:|.........:..||
Worm  1271 ------------TPEQEVE-LKNVRIPR-----------VVLPTIARSAMFQQTWEK-------- 1303

  Fly  1439 INGSWFTGHSVAVKANYKDRSSRVQALHHLKMIVESPSFNITSLNIIYRRKQLLIFYDIQAK-YD 1502
                  ||.:..|     |:|             |..:|:    |:|| |..|...|.:.|| ..
Worm  1304 ------TGATCKV-----DQS-------------EVSTFD----NVIY-RAPLTTCYSLVAKDCS 1339

  Fly  1503 QDPYGLTIQYASNAHNRNTNA-EVRLKVKERDYWINAKLLSEQPKLLQLEIHMDKIRDVHIQVGL 1566
            :.|     ::|..|...|.|: |:.:||..|:.                ||.:.|..|..    |
Worm  1340 EQP-----RFAVLAKKINKNSEELLVKVVRREE----------------EIVVKKSDDKF----L 1379

  Fly  1567 LNVDKRKELSLELKWDANRDPSQRLGLLAEYNSP--GTKHYDGNLMITYPERTIHF-GFNSFTGG 1628
            :.||.:|....||:               :||..  |    |..::|..|:..:.| |:...|..
Worm  1380 VKVDGKKVNPTELE---------------QYNIEILG----DNLIVIRLPQGEVRFDGYTVKTNM 1425

  Fly  1629 P 1629
            |
Worm  1426 P 1426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Apoltp	NP_995670.2	LPD_N	49..633	CDD:214755	143/679 (21%)
		DUF1943	665..1012	CDD:286281	72/394 (18%)
		DUF1081	1029..1122	CDD:283982	17/95 (18%)
		VWD	3741..3908	CDD:295339
		C8	3951..4014	CDD:285899
vit-5	NP_508589.1	Vitellogenin_N	24..617	CDD:279663	143/679 (21%)
		DUF1943	651..942	CDD:286281	72/363 (20%)
		VWD	1300..1454	CDD:214566	46/208 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I7810
eggNOG	1	0.900	-	-		E1_KOG4338
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23345
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910