DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Apoltp and vit-6

DIOPT Version :9

Sequence 1:	NP_995670.2	Gene:	Apoltp / 34283	FlyBaseID:	FBgn0032136	Length:	4333	Species:	Drosophila melanogaster
Sequence 2:	NP_001023276.1	Gene:	vit-6 / 177619	WormBaseID:	WBGene00006930	Length:	1651	Species:	Caenorhabditis elegans

Alignment Length:	1859	Identity:	339/1859 - (18%)
Similarity:	616/1859 - (33%)	Gaps:	614/1859 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 IWLLLL---IAHTQAVRENPLKDPRICGRPQCDSKSAKFNYGEQLYKYQYTVAVRTEFAGSGDNS 71
            |.|.||   :|.|...|.|.:         :.:.:.:.|..|.: |:|.:          :|..|
Worm     5 IALALLGAALASTHLDRYNSI---------ERNIQESSFRAGRE-YRYLF----------NGQLS 49

  Fly    72 SDLLLKSDLEIFFPKPCEGYLRIND-------------AKLYDTLDELNDNESDSSEKTKEYDYY 123
            :.|.:        |...:|..|:..             .:|..|....:..||:|. |...::.:
Worm    50 AGLPV--------PSTPQGISRLQSQVTLQWTDGNTVRMQLQKTRFATSQQESNSM-KMLPFERF 105

  Fly   124 DNLANEESESQNYDNMHPKSSDFNVDLTKNLLRFAFHDGLISEVCPQEQETPWVLNIKKGILSAF 188
                 ||.|..|.::.         :|....:.|.:..||:.|:...|.:.||..|||:.:::..
Worm   106 -----EEVERMNREHQ---------ELLSMPVEFDYEHGLVREIRFAENDQPWSENIKRAVINML 156

  Fly   189 QNTMMRFDVDANTTETD--------------VSGQCQVQYALEDTDSSYVTIRK------TKDIN 233
            |..:::.:......::|              :.|:|:|.|.:|:       |:|      .|.||
Worm   157 QVNILKKEKYEGAEKSDNQEPTFSFTNVERTLEGECEVLYTVEE-------IKKEDEQRWAKSIN 214

  Fly   234 --SCRQRYATHSVLQTTP------YTFRDDKTIWPILKSQSHCNLTIDNNVY--KEIKCLETHLL 288
              .|.:|...|.|  .||      .|...||....:|    :.|:|..::.:  ..::....||.
Worm   215 FDKCTRRPYIHHV--QTPVCKDCQQTLEQDKMSSTVL----NYNITGTSSSFLINSVELRSQHLF 273

  Fly   289 VPFSNASS--GALTTSTSRLKLDGVESYSAGEFLEQNPELV----ERRATLVFDHTPAVKPSHDE 347
            .|.|....  .|.|.:|..|...|          |:..|:.    |:.:.||:         :.|
Worm   274 APISEKHQLVSAFTLNTMELIYAG----------EKKTEIKQVRNEKTSELVY---------NQE 319

  Fly   348 IKAARELLVEMCRVGFPNIQREFIDVFTNFLQTSKSLDYKTLSVLLQRSASTCEQGRNHLLESLP 412
            .:.|.:   :..:.|    :.:::.....:.:....:..|..|::    |...|||... ||:..
Worm   320 SEWAEQ---QWAQTG----EEKYLRQLPQWTENKVEMIKKMFSLM----AKQIEQGEAE-LEAAH 372

  Fly   413 FIGSTASYKVMR-------DQII-------NEKLTKQMAHDWMTALSFI-TRPDEETLETFHSIL 462
            .:....  ||:|       :||.       :||:.:|:...:...|:.. ||   .|::.|...:
Worm   373 TVARIV--KVLRECNEEQLEQIYRHVAEHKDEKIAEQLRSIYFNTLALAGTR---VTIQQFVDKV 432

  Fly   463 EYAKN------------RLDAEY------------------------------TLGATAVVHSFC 485
            :..||            .:|..|                              |.|  |:|:..|
Worm   433 QSRKNIAPLKASVAIKTLVDMRYPSLAIAEDIARLCESDVSSSFPALRQSCWLTYG--AIVNGVC 495

  Fly   486 KHH----------EACEENLRVQQIINLLETEFLNLYNLFKGERRTRERMVILLKGLGNIGVVSS 540
            ...          :.|..:.: |:|::.|..:|        ....||...|:.||.|.|.|:..|
Worm   496 GQTPRVFVQKNGVKMCPRDAK-QRIVDKLVQQF--------ESASTRYEKVLALKTLANAGLDLS 551

  Fly   541 AFAEQLQWIIREDEAPVDIRLHGILAFRRVDC---ARHRSYFLDNYGNYTLNSELRIYSYLQAMR 602
            .:  .|:.||..::....||...|.:|||:..   .:.:...:..|.|......:|:.:..|.:.
Worm   552 VY--PLEKIILNEQHETTIRTQAIESFRRLRTQMPTKIQRVLMPVYLNRQQPQHIRMSALHQIIY 614

  Fly   603 C-PDYISVGVIKSILEHEEINQVGSFVWSHLTNLAKSNSPVR----IEAQGLLLNDELS----ER 658
            . |::..:..|.:.|..|...||.:|..|.|.:.|.:.||..    ...|.||.|...|    :|
Worm   615 TQPEWSVLSQIGNQLRQERNQQVRAFTLSLLRSYANNESPCEQTFSSRVQSLLNNIPFSSQEIDR 679

  Fly   659 FKMDIRK---FSRNYEHSLFFDEYNFGTTTDANVIFGTDSYLPRIASVNFTADLFGQSVNFFE-- 718
            |:....|   :||.::...   |.||.:      :|.|:|.||.....:....|.|:...:|.
Worm   680 FESVYGKWSTYSRRHQSGF---EANFAS------LFTTESVLPTEMMASIEGVLSGEWNQYFAQI 735

  Fly   719 -FT--------------ARAEGLEELAANAFGPKGPLSGQLLRKKLSFLNRWLGNESAEEDDTLE 768
             ||              .:.:|||::........|                     |.:..:.|.
Worm   736 GFTQKNMEKIIKKLLSNVQEKGLEQIVVRGKRASG---------------------SFQPTEFLS 779

  Fly   769 NLLSLDNLRLKRKAQEQARASEEEV---------DEDYDFEESLEGNKRQKRDVSTTRKQEIDRN 824
            ||  |:.||:.|:     ::||::.         |.||.|                     :..:
Worm   780 NL--LEKLRITRR-----QSSEQDPHAFVYIRHRDMDYAF---------------------LPID 816

  Fly   825 VDSLGYKLKYDYNNPRAQFGLRVFGNDLRYFNVESLVEVMALAAKFNPFQQAKNVLSGKEFTYTK 889
            .||:...::......|.:.|              .:..|:|....|:        .|...|.|..
Worm   817 ADSIPEVVRSMIQGGRLEIG--------------DIERVLAQGIHFS--------ASNAAFLYET 859

  Fly   890 SRVFLDASYTVPLAVGLPLAIHAFGASSIDLRVSGNLD-EMDPPTDWHFD---VEGQFKPSVSVD 950
            .|       .||..:|||:...:...:...:|  |.:. |::|.....||   :..|..|.|:..
Worm   860 VR-------RVPTPMGLPVQFTSKMPTISSIR--GQVTFELEPKNGKSFDGLRLRVQAGPRVAST 915

  Fly   951 VITTMQTDMFWEQSGIKVKSNLYSNSELVAKLKVRGRN--LVSFSFDLPRDKNEIFSVRSELLVQ 1013
            .:.:::......:.|.|.......|:.:..::::...:  ::...::.|.::..|..::|..:..
Worm   916 HVLSLRVICPIAEVGTKFLHQAVLNTPVDTEIRMNWEDKVVIRAIYNTPSEEKRIAMIQSRPVTF 980

  Fly  1014 KR-----EEQLPQAGIANRSANSTCTWPVLDQAIGLQMCSHYSVP---DLSNATE-IYPSLLLAG 1069
            .|     ..|.|:.                     ::|.  |.:|   .||.:.: .||.:.:.|
Worm   981 TRTVAPDARQYPEP---------------------IEMT--YMLPAHKQLSQSLDREYPQIRVQG 1022

  Fly  1070 PLNFSLILKKSDLSAKKYVFEYKWDQQEEDNNFSLVFTTPGSKVPRVLVANVTKVPDAFNASVAF 1134
            .||     :.:.:...:::.         |:|.. |:..|          ||.:....|.
Worm  1023 TLN-----RPTSVRIPQWIV---------DSNVE-VYYKP----------NVEQYEAIFE----- 1057

  Fly  1135 VNGPNRVSAGCSYDGNPDFRRLDIYLDTNGNRSLDLGMEL--RRHQDFTA----WIYNPRMLLAI 1193
            :|..|......:|:        .:|...||.|.|:...|.  ..|::...    |:.|.:
Worm  1058 LNLYNNYKMEKNYE--------KVYKKHNGRRYLEAEPEYDEEEHREQITKKFEWLQNEK----- 1109

  Fly  1194 NGVNITGLAGTVKVNEKNGIKQHDVDLSFETKKLQAVIKGNVVQSEITTSTNMTIKYRFQANKIE 1258
                               :.||..  .||       ||..||:.|:....|            .
Worm  1110 -------------------VYQHVA--KFE-------IKPEVVKMEVEAVCN------------N 1134

  Fly  1259 EINFAGKLVNNGDKSKTEYRGNMKLQTS---AYPKLNFASESTWLSLQGHTE----GMITYNNAP 1316
            :.:|.          ||:.||. :|:.:   .||:.....|.  |..|.:.:    |.:.|....
Worm  1135 DFHFC----------KTQIRGE-ELKATIQYVYPQTPRTVEE--LKEQKYRQLVVMGEMNYGENT 1186

  Fly  1317 DYVNPNYTSLVRLIFARSHSEDSFLDGTQTRASLELKLPRSKIDYRILVKHKEHIKNGTEHNVIV 1381
            .::|.|        ..:|..:..|:...:.....|..|..|::|               ::..:|
Worm  1187 IHININ--------GQQSQEQKKFVKQIEQAPEHETLLEASRLD---------------QYQTVV 1228

  Fly  1382 GLKYTPEKEITGLFSVHLPRRNLFA-----IDAYMNVTVPEFNSCTASLKVNEKATKDYII---- 1437
            ..::.|:.            ...||     :.||:....|    .|:.::..|:.::..:|
Worm  1229 EYEFEPKP------------AQYFARYWNMVQAYLRTQYP----WTSRIETREEPSRKNMIRATI 1277

  Fly  1438 --------FINGSWFTGHSVAV-------------KANYKDRSSRVQ-------ALHH----LKM 1470
                    .:|.:..|.....|             :.:|:.|:||.:       ..||    ...
Worm  1278 NVEPRQRLTVNMTIETPMETTVLERVELPFRLPTAQIHYQPRNSRYEQKPVMEKIAHHASKQANC 1342

  Fly  1471 IVESPSFNITSLNIIYRRKQLLIFYDIQAK----YDQDPYGLTIQYASNAHNRNTNAEV------ 1525
            :|:|...| |...:.| |.|....|.:.||    ...:|..:.:....|......|.:|
Worm  1343 VVKSTKIN-TFDQVAY-RNQFTPCYSVLAKDCGSEKSEPRFVVLMKKINEKKEWKNVKVVYGENE 1405

  Fly  1526 ------------RLKVKERDYWINAKLLSEQPKLLQLEIHMDKIRDVHIQVGLLNVDKRKELSLE 1578
                        |:..:|.:|...:::..:|..::.|..:..|.....:.|....|:.|..||..
Worm  1406 IEMYKTEEGLICRVNGEEIEYQPESEIEKKQYNIIWLNKNTLKFDSDDVTVQFDGVNARIHLSAL 1470

  Fly  1579 LKWDANRDPSQRLGLLAEY-NSPGTKHYDG-NLMITYPE 1615
            .:       :|:.||...| |...|:.||. |...|.|:
Worm  1471 YR-------NQQCGLCGHYDNEKETEFYDAENQENTIPK 1502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Apoltp	NP_995670.2	LPD_N	49..633	CDD:214755	135/703 (19%)
		DUF1943	665..1012	CDD:286281	65/381 (17%)
		DUF1081	1029..1122	CDD:283982	15/96 (16%)
		VWD	3741..3908	CDD:295339
		C8	3951..4014	CDD:285899
vit-6	NP_001023276.1	Vitellogenin_N	34..646	CDD:279663	137/707 (19%)
		DUF1943	679..979	CDD:286281	67/388 (17%)
		VWD	1339..1495	CDD:214566	33/164 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I7810
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23345
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010