DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Trx-2 and TXNDC5

DIOPT Version :9

Sequence 1:	NP_523526.1	Gene:	Trx-2 / 34281	FlyBaseID:	FBgn0040070	Length:	106	Species:	Drosophila melanogaster
Sequence 2:	NP_110437.2	Gene:	TXNDC5 / 81567	HGNCID:	21073	Length:	432	Species:	Homo sapiens

Alignment Length:	80	Identity:	25/80 - (31%)
Similarity:	42/80 - (52%)	Gaps:	4/80 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 TKASGKLVVLDFFATWCGPCKMISPKLVELSTQFADNVVVLKVDVDEC---EDIAMEYNISSMPT 77
            |.|.| :..:.|:|.|||.||.::|...|||.:....:..:|:...:|   .:|..:|::...||
Human   335 TIAEG-ITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPT 398

  Fly    78 FVFLKNGVKVEEFAG 92
            .:..:.|.||.|.:|
Human   399 LLLFRGGKKVSEHSG 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trx-2	NP_523526.1	TRX_family	18..103	CDD:239245	24/78 (31%)
TXNDC5	NP_110437.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..63
		PDI_a_ERp46	61..164	CDD:239303
		ER_PDI_fam	66..432	CDD:273457	25/80 (31%)
		PDI_a_ERp46	190..290	CDD:239303
		PDI_a_ERp46	323..424	CDD:239303	25/80 (31%)
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	429..432
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910