DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Trx-2 and PDIA5

DIOPT Version :9

Sequence 1:	NP_523526.1	Gene:	Trx-2 / 34281	FlyBaseID:	FBgn0040070	Length:	106	Species:	Drosophila melanogaster
Sequence 2:	NP_006801.1	Gene:	PDIA5 / 10954	HGNCID:	24811	Length:	519	Species:	Homo sapiens

Alignment Length:	107	Identity:	30/107 - (28%)
Similarity:	54/107 - (50%)	Gaps:	12/107 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KDKADLDGQ-----LTKASGKLVVLDFFATWCGPCKMISPKLVELSTQFADNVVVLKVDV--DEC 63
            ||...||.:     |.|...|.:::.|:|.||..||.:.|...:.:||...:.|:..::|  .|.
Human   151 KDVVHLDSEKDFRRLLKKEEKPLLIMFYAPWCSMCKRMMPHFQKAATQLRGHAVLAGMNVYSSEF 215

  Fly    64 EDIAMEYNISSMPTFVFLKNGVKVEEF--AGANAKRLEDVIK 103
            |:|..||::...||..:.:.|..:.::  .|:.|   ||:::
Human   216 ENIKEEYSVRGFPTICYFEKGRFLFQYDNYGSTA---EDIVE 254

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trx-2	NP_523526.1	TRX_family	18..103	CDD:239245	24/88 (27%)
PDIA5	NP_006801.1	PDI_b_PDIR_N	28..139	CDD:239365
		PDI_a_PDIR	152..256	CDD:239295	29/106 (27%)
		PTZ00102	168..512	CDD:240266	24/90 (27%)
		PDI_a_PDIR	277..379	CDD:239295
		PDI_a_PDIR	398..501	CDD:239295
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	516..519
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910