DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Trx-2 and Txndc5

DIOPT Version :9

Sequence 1:	NP_523526.1	Gene:	Trx-2 / 34281	FlyBaseID:	FBgn0040070	Length:	106	Species:	Drosophila melanogaster
Sequence 2:	NP_663342.3	Gene:	Txndc5 / 105245	MGIID:	2145316	Length:	417	Species:	Mus musculus

Alignment Length:	85	Identity:	23/85 - (27%)
Similarity:	49/85 - (57%)	Gaps:	3/85 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 LDFFATWCGPCKMISP--KLVELSTQFADNVVVLKVDVDECEDIAMEYNISSMPTFVFLKNGVKV 87
            :.|||.|||.||.::|  :.:.|..:.::.|.:.|||..:...:..|:.:...||.::.::|.||
Mouse   196 IKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYAVCSEHQVRGYPTLLWFRDGKKV 260

  Fly    88 EEFAG-ANAKRLEDVIKANI 106
            :::.| .:.:.|.|.:::.:
Mouse   261 DQYKGKRDLESLRDYVQSQL 280

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trx-2	NP_523526.1	TRX_family	18..103	CDD:239245	23/80 (29%)
Txndc5	NP_663342.3	PDI_a_ERp46	47..150	CDD:239303
		ER_PDI_fam	52..417	CDD:273457	23/85 (27%)
		PDI_a_ERp46	176..276	CDD:239303	23/79 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	281..302		23/85 (27%)
		PDI_a_ERp46	308..409	CDD:239303
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	414..417
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910