Protein Alignment gcm2 and GCM2

DIOPT Version :10

• Sequence 1: NP_609302.1
• Gene: gcm2 / 34280
• FlyBaseID: FBgn0019809
• Length: 606
• Species: Drosophila melanogaster
• Sequence 2: NP_004743.1
• Gene: GCM2 / 9247
• HGNCID: 4198
• Length: 506
• Species: Homo sapiens
• Alignment Length: 488
• Identity: 165/488 - (33%)
• Similarity: 226/488 - (46%)
• Gaps: 138/488 - (28%)

  Fly    42 PSPGQQQAGG--SMTMPSSSTGKGKREWDINDAIVPHVPDQE---FDEFNEWSDGHVRHIYSLHN 101
            |:...|:|.|  |..|..|        |||||   |.:| ||   ||:|.||.||:||.|||...
Human     2 PAAAVQEAVGVCSYGMQLS--------WDIND---PQMP-QELALFDQFREWPDGYVRFIYSSDE 54

  Fly   102 EEAKKHISGWAMRNTNNHNVNILKKSCLGVLVCSQHCTLPNGSKINLRPAICDKARRKQEGKACP 166
            ::|::|:||||||||||||.:|||||||||:||:|.||||:||::.||||||||||.||:.||||
Human    55 KKAQRHLSGWAMRNTNNHNGHILKKSCLGVVVCTQACTLPDGSRLQLRPAICDKARLKQQKKACP 119

  Fly   167 NKSCRGGRLEIKPCRGHCGYPVTHFWRHSGNAIFFQAKGVHDHLRPDPKNSSVSKRAFGRVPLAG 231
            |  |... ||:.|||||.|||||:|||..||||||||||||||.||:.|:.:.::|:      |.
Human   120 N--CHSA-LELIPCRGHSGYPVTNFWRLDGNAIFFQAKGVHDHPRPESKSETEARRS------AI 175

  Fly   232 KSANGSV---AKKSVIAGLVKQAKQQHSLISKVLKRPAVSNP-----LAHTAL------------ 276
            |....|.   .||.:.....::.:......|.:   |.:.||     :..|:.
Human   176 KRQMASFYQPQKKRIRESEAEENQDSSGHFSNI---PPLENPEDFDIVTETSFPIPGQPCPSFPK 237

  Fly   277 -DIYQYNACGKCAGYSHCTCSYLDDSTTARSHQLSQSSNYGTNSWPLSGSESSAPCETAANVFTV 340
             |:|:            .||    |..|.:..::.....|.:....|    ...||
Human   238 SDVYK------------ATC----DLATFQGDKMPPFQKYSSPRIYL----PRPPC--------- 273

  Fly   341 NHQHITYNYPIYHATPAAATAAP-----SKSPSLP----------YACSISELAAYQQS------ 384
                   :|.:  |.|....::|     ..|.|:|          ..|:::..::|::|
Human   274 -------SYEL--ANPGYTNSSPYPTLYKDSTSIPNDTDWVHLNTLQCNVNSYSSYERSFDFTNK 329

  Fly   385 SSGNSFAMGVPV------HGHTQCQAVAYDSSPQ-----LATPEPEFINYSQIKHLGGGGGQ--- 435
            ..|...|:|.|.      ||..|..|.....:|:     |.||.|           |....|
Human   330 QHGWKPALGKPSLVERTNHGQFQAMATRPYYNPELPCRYLTTPPP-----------GAPALQTVI 383

  Fly   436 ---EEISCKAEPGPTIKYNATV-ETQPYVEDNY 464
               .::|.:|...|.:||:.:| |.:.....||
Human   384 TTTTKVSYQAYQPPAMKYSDSVREVKSLSSCNY 416

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gcm2	NP_609302.1	GCM	82..222	CDD:397602	94/139 (68%)
GCM2	NP_004743.1	GCM	35..172	CDD:397602	94/139 (68%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	155..213		16/66 (24%)
		C-terminal conserved inhibitory domain (CCID). /evidence=ECO:0000269|PubMed:27745835	379..395		3/15 (20%)