DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gcm2 and gcm2

DIOPT Version :9

Sequence 1:	NP_609302.1	Gene:	gcm2 / 34280	FlyBaseID:	FBgn0019809	Length:	606	Species:	Drosophila melanogaster
Sequence 2:	NP_001005603.1	Gene:	gcm2 / 449615	ZFINID:	ZDB-GENE-050127-1	Length:	496	Species:	Danio rerio

Alignment Length:	511	Identity:	161/511 - (31%)
Similarity:	223/511 - (43%)	Gaps:	138/511 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 KREWDINDAIVPHVPD--QEFDEFNEWSDGHVRHIYSLHNEEAKKHISGWAMRNTNNHNVNILKK 126
            |..|||||   |.:|.  :::|.|.||:||:||:|||..::.|::|:||||||||||||..||||
Zfish    20 KLTWDIND---PKLPQDTKQYDAFQEWTDGYVRYIYSSEDKNAQRHLSGWAMRNTNNHNCQILKK 81

  Fly   127 SCLGVLVCSQHCTLPNGSKINLRPAICDKARRKQEGKACPNKSCRGGRLEIKPCRGHCGYPVTHF 191
            |||||:|||::|:||:|||:.||||||||||:||:.|.|||  |... ||:.|||||.|||||:|
Zfish    82 SCLGVVVCSRNCSLPDGSKLQLRPAICDKARQKQQKKLCPN--CNSA-LELIPCRGHSGYPVTNF 143

  Fly   192 WRHSGNAIFFQAKGVHDHLRPDPKNS-----SVSKRAFGRVPLAGKSANGSVAKKSV-------- 243
            ||..|.||||||||||||.||:.|:.     |..||.....|.:.|       ::.|
Zfish   144 WRVDGKAIFFQAKGVHDHPRPESKSETEARRSAVKRRMSSPPFSQK-------RRLVEPEPGRYH 201

  Fly   244 ------IAGLVKQAKQQHSLIS------KVLKRPAVSNPL-------AHTALDIYQYNACGKCA- 288
                  |..|..:..::.|:|:      :....|...||.       .|.|......::..|.|
Zfish   202 DMAFPNIHQLTMEGPERFSIIAESNFPIQTQHYPTFQNPEPYKFPYDTHAAAMADAQSSLQKPAN 266

  Fly   289 ----------GYSHCTCSYLDD---------------------------------STTARSHQLS 310
                      ||......||..                                 |:...||:.|
Zfish   267 HRLYVTRPPCGYDFAVPGYLGSGPYPAALYKDPSSPQMETEPNKSGSSLSGVSHGSSPLGSHERS 331

  Fly   311 QSSNYGT-NSWP--LS-------GSESSAPCETAANVFTVNHQHITYNYPIYHATPAAATAAPSK 365
            .:.:.|. :.|.  ||       |..|..|.       ..||.:...:||..:..|||.|.|
Zfish   332 YAESSGKHHGWKQILSKGGYGDRGDYSQLPT-------NANHHYYNSDYPCRYTGPAAPTPA--- 386

  Fly   366 SPSLPYACSISELAAYQQSSSGNSFAMG---VPVHGHTQCQAVAYDSSPQLATPEPEFINYSQIK 427
              :|....:.:...:||.....:....|   ..|.|.:.|.::..:.||.         :||.:|
Zfish   387 --ALQTIITTTTKVSYQPCPKPSVVKYGENIYDVKGLSNCNSILEEPSPN---------SYSDLK 440

  Fly   428 HLGGGGGQEEISCKAEPGPTIKYNATVETQPYVEDNYDYY----YSPKAEYEMQQH 479
            .....|..:.         .:.|..|:..:....:|::.|    ||..:..|...|
Zfish   441 IPEDSGVIKS---------ALSYQDTLPAKIERSENFEGYRYSSYSANSYPERMSH 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gcm2	NP_609302.1	GCM	82..222	CDD:281598	92/144 (64%)
gcm2	NP_001005603.1	GCM	37..174	CDD:281598	91/141 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579431
Domainoid	1	1.000	206	1.000	Domainoid score	I2857
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003094
OrthoInspector	1	1.000	-	-		otm25340
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12414
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4583
SonicParanoid	1	1.000	-	-		X4579
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	8.060